A 73-year-old woman presented to our hospital with a 1-year history of epiphora associated with discharge on the left eye. On the first examination, there was a swelling in the medial part of the left lower eyelid associated with a cystic change along the lacrimal canaliculus. On digital compression, there was an expression of a yellow mucopurulent discharge from the left-lower punctum. A culture test of the discharge showed Campylobacter concisus (1+), Gemella morbillorum (1+), Fusobacterium nucleatum (1+), and Porphyromonas gingivalis (2+). Complete removal of the canaliculoliths was done with a curette. Dacryoendoscopic examination showed a substantially dilated horizontal canaliculus accompanied with granulation and fibrous tissues on the left-lower side. An ofloxacin ointment-coated bicanalicular tube was inserted. Also, an oral antibiotic was administered for 14 days after surgery. At a 3-month follow-up, the patient did not have any symptoms associated with canaliculitis.