背景:多囊卵巢综合征(PCOS)是最常见的卵巢功能障碍。最近的研究表明,甘草对代谢谱的有效性,但发现不一致。所以,我们调查了甘草对肥胖指数的影响,血糖指数,PCOS女性的血脂状况。
方法:这是随机的,双盲,我们对66名超重/肥胖的PCOS女性进行了安慰剂对照试验.参与者被随机分配接受1.5克/天的甘草提取物加低热量饮食(n=33)或安慰剂加低热量饮食(n=33),为期8周。使用标准协议评估参与者的人体测量指数和身体成分。空腹血糖(FBS),胰岛素水平,低密度脂蛋白胆固醇(LDL-C),总胆固醇(TC),甘油三酯(TG),使用酶试剂盒测量高密度脂蛋白胆固醇(HDL-C)。使用有效公式计算稳态模型评估-胰岛素抵抗(HOMA-IR)和β细胞功能的HOMA(HOMA-B)。
结果:组间比较表明,两组之间在肥胖指数方面存在显着差异(体重,BMI,和身体脂肪),血脂谱(TG,TC,LDL-C,和HDL-C),FBS和胰岛素水平,HOMA-IR,研究结束时HOMA-B(P<0.05)。在调整混杂因素后,补充甘草加低热量饮食也比单独低热量饮食更有效地改善所有参数(基线值,年龄,体重变化,和身体活动变化)(P<0.05)。
结论:研究结果表明,食用甘草可以改善肥胖指数,葡萄糖稳态,和与安慰剂相比的脂质分布。由于本研究可能存在的局限性,需要进一步的研究来证实这些发现.
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common ovarian dysfunction. Recent studies showed the effectiveness of licorice on metabolic profiles with inconsistent findings. So, we investigated the effect of licorice on obesity indices, glycemic indices, and lipid profiles in women with PCOS.
METHODS: This randomized, double-blind, placebo-controlled trial was performed on 66 overweight/obese women with PCOS. The participants were randomly assigned to receive either 1.5 gr/day licorice extract plus a low-calorie diet (n = 33) or placebo plus a low-calorie diet (n = 33) for 8 weeks. Participants\' anthropometric indices and body composition were assessed using standard protocols. Fasting blood sugar (FBS), insulin levels, low-density lipoprotein-cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), and high-density lipoprotein-cholesterol (HDL-C) were measured using enzymatic kits. The homeostasis model assessment-insulin resistance (HOMA-IR) and HOMA of β-cell function (HOMA-B) were calculated using valid formulas.
RESULTS: Between-group comparisons demonstrated significant differences between the groups in terms of obesity indices (body weight, BMI, and body fat), lipid profiles (TG, TC, LDL-C, and HDL-C), FBS and insulin levels, HOMA-IR, and HOMA-B at the end of the study (P < 0.05). Supplementation with licorice plus a low-calorie diet was also more effective in improving all parameters than a low-calorie diet alone after adjusting for confounders (baseline values, age, weight changes, and physical activity changes) (P < 0.05).
CONCLUSIONS: The findings showed that licorice consumption leads to improvements in obesity indices, glucose homeostasis, and lipid profiles compared to placebo. Due to possible limitations of the study, further research is needed to confirm these findings.