■巨细胞病毒(CMV)可以感染任何年龄的个体,包括婴儿,谁可能从受感染的母亲那里感染(先天性CMV[cCMV])。尽管CMV感染通常无症状或在健康个体中引起轻度疾病,感染可导致免疫功能低下个体和cCMV婴儿的严重结局.本系统综述旨在描述CMV和cCMV感染的经济影响。
■Medline,Embase,在LILACS数据库中搜索了报告cCMV和CMV感染对所有年龄组的经济影响的出版物.2010年至2020年期间从澳大利亚出版的手稿,拉丁美洲,加拿大,欧洲,以色列,Japan,美国,和全球(国际,全球)研究被纳入;国会材料被排除在外。利息结果包括cCMV-和CMV-可归因于直接成本/费用,资源利用率,以及间接/社会成本。
■在确定的751条记录中,518个基于重复被排除在外,人口,结果,研究设计,或国家。总的来说,55篇文章符合全文审查条件;25篇文章因人口原因被进一步排除在外,结果,研究设计,或国会摘要。还确定了两份出版物,产生了从32种出版物中汇编的经济影响数据。其中,24种出版物报道了cCMV或CMV的成本研究,包括直接成本/费用的评估,医疗保健资源利用,以及间接/社会成本,和7种出版物报告了干预措施的经济评估。人口,这些研究中使用的方法和结果差异很大.
■CMV和cCMV感染对不同国家造成了相当大的经济影响,人口,和结果。有大量的证据空白需要进一步的研究。
Cytomegalovirus (CMV) can infect individuals at any age, including infants, who may contract it from infected mothers (congenital CMV [
cCMV]). Whereas CMV infection is typically asymptomatic or causes mild illness in healthy individuals, infection can result in severe outcomes in immunocompromised individuals and in infants with cCMV. This systematic review aims to characterize the economic impact of CMV and
cCMV infections.
Medline, Embase, and LILACS databases were searched for publications reporting the economic impact of
cCMV and CMV infections across all age groups. Manuscripts published between 2010 and 2020 from Australia, Latin America, Canada, Europe, Israel, Japan, the United States, and global (international, worldwide) studies were included; congress materials were excluded. Outcomes of interest included
cCMV- and CMV-attributable direct costs/charges, resource utilization, and indirect/societal costs.
Of 751 records identified, 518 were excluded based on duplication, population, outcome, study design, or country. Overall, 55 articles were eligible for full-text review; 25 were further excluded due to population, outcome, study design, or congress abstract. Two publications were additionally identified, resulting in economic impact data compiled from 32 publications. Of these, 24 publications reported cost studies of
cCMV or CMV, including evaluation of direct costs/charges, healthcare resource utilization, and indirect/societal costs, and 7 publications reported economic evaluations of interventions. The populations, methods and outcomes used across these studies varied widely.
CMV and cCMV infections impose a considerable economic impact on different countries, populations, and outcomes. There are substantial evidence gaps where further research is warranted.