背景:特征正念,倾向于在没有判断的情况下关注当下的经历,与青少年焦虑和抑郁呈负相关。了解特质正念的神经机制可能会为精神疾病的神经基础提供信息。然而,很少有研究确定与青春期特质正念相关的大脑连接状态,他们也没有评估这些国家的可靠性。
方法:为了解决这个知识差距,我们通过2次功能磁共振成像(fMRI)扫描对106名12~15岁青少年(50%为女性)的大脑状态进行了严格评估.我们进行了静态和动态功能连通性分析,并评估了青少年在每种状态下花费多少时间的重测可靠性。对于可靠的国家,我们评估了与自我报告的特质正念的关联。
结果:较高的特质正念与较低的焦虑和抑郁症状相关。静态功能连接(ICC从0.31-0.53)与特质正念无关。在我们确定的动态大脑状态中,大多数人在扫描中不可靠。然而,一个国家,网络之间提升的正连接的超连接状态,表现出良好的可靠性(ICC=0.65)。我们发现,青少年在这种超连接状态中花费的时间与特质正念呈正相关。
结论:通过对超过100次静息状态fMRI扫描应用动态功能连接分析,我们确定了一个高度可靠的大脑状态,与特质正念相关。大脑状态可能反映了一种正念状态,或者更普遍的意识和唤醒,这在那些特质正念较高的人中可能更明显。
UNASSIGNED: Trait mindfulness, the tendency to attend to present-moment experiences without judgement, is negatively correlated with adolescent anxiety and depression. Understanding the neural mechanisms underlying trait mindfulness may inform the neural basis of psychiatric disorders. However, few studies have identified brain connectivity states that correlate with trait mindfulness in adolescence, nor have they assessed the reliability of such states.
UNASSIGNED: To address this gap in knowledge, we rigorously assessed the reliability of brain states across 2 functional magnetic resonance imaging (fMRI) scan from 106 adolescents aged 12 to 15 (50% female). We performed both static and dynamic functional connectivity analyses and evaluated the test-retest reliability of how much time adolescents spent in each state. For the reliable states, we assessed associations with self-reported trait mindfulness.
UNASSIGNED: Higher trait mindfulness correlated with lower anxiety and depression symptoms. Static functional connectivity (ICCs from 0.31-0.53) was unrelated to trait mindfulness. Among the dynamic brains states we identified, most were unreliable within individuals across scans. However, one state, an hyperconnected state of elevated positive connectivity between networks, showed good reliability (ICC=0.65). We found that the amount of time that adolescents spent in this hyperconnected state positively correlated with trait mindfulness.
UNASSIGNED: By applying dynamic functional connectivity analysis on over 100 resting-state fMRI scans, we identified a highly reliable brain state that correlated with trait mindfulness. The brain state may reflect a state of mindfulness, or awareness and arousal more generally, which may be more pronounced in those who are higher in trait mindfulness.