背景:在多孔植入物中包含连接路径可以促进营养向细胞的扩散并增强骨向内生长。因此,这项研究旨在评估生物力学,射线照相,新型3D打印多孔缝合锚钉在兔股骨模型中的组织病理学表现。
方法:根据缝合锚钉(SA)的类型形成三个测试组:商业SA(CSA,A组,n=20),自定义固体SA(CSSA,B组,n=20),和定制多孔SA(CPSA,C组,n=20)。将SAs植入每只兔右腿的股骨外侧髁中。兔子(新西兰白兔,男性,平均体重2.8±0.5公斤,年龄8个月)接受相同的治疗,并通过计算机生成的随机化随机分为实验组和对照组。在植入后0、4、8和12周对5只兔子(10个股骨髁)进行显微CT安乐死,组织学分析,和生物力学测试。
结果:在12周时,CPSA的BV/TV(中位数0.7301,IQR0.7276-0.7315)高于CSSA和CSA.组织学分析显示SA附近的矿化骨细胞。4周时,在CPSA周围观察到新骨,并穿透了其多孔结构。到了12周,CSA和CPSA的极限失效载荷没有显著差异。
结论:我们证明了创新的3D打印多孔缝合锚钉在术后12周的时间点表现出与传统螺纹缝合锚钉相当的拔出强度。此外,我们的多孔锚设计增强了新骨形成并促进了骨生长到植入物结构中,提高生物力学稳定性。
BACKGROUND: The inclusion of a connecting path in a porous implant can promote nutrient diffusion to cells and enhance bone ingrowth. Consequently, this study aimed to evaluate the biomechanical, radiographic, and histopathological performance of a novel 3D-printed porous suture anchor in a rabbit femur model.
METHODS: Three test groups were formed based on the type of suture anchor (SA): Commercial SA (CSA, Group A, n = 20), custom solid SA (CSSA, Group B, n = 20), and custom porous SA (CPSA, Group C, n = 20). The SAs were implanted in the lateral femoral condyle of the right leg in each rabbit. The rabbits (New Zealand white rabbits, male, mean body weight of 2.8 ± 0.5 kg, age 8 months) underwent identical treatment and were randomized into experimental and control groups via computer-generated randomization. Five rabbits (10 femoral condyles) were euthanized at 0, 4, 8, and 12 weeks post-implantation for micro-CT, histological analysis, and biomechanical testing.
RESULTS: At 12 weeks, the CPSA showed a higher BV/TV (median 0.7301, IQR 0.7276-0.7315) than the CSSA and CSA. The histological analysis showed mineralized osteocytes near the SA. At 4 weeks, new bone was observed around the CPSA and had penetrated its porous structure. By 12 weeks, there was no significant difference in ultimate failure load between the CSA and CPSA.
CONCLUSIONS: We demonstrated that the innovative 3D-printed porous suture anchor exhibited comparable pullout strength to conventional threaded suture anchors at the 12-week postoperative time-point period. Furthermore, our porous anchor design enhanced new bone formation and facilitated bone growth into the implant structure, resulting in improved biomechanical stability.