bone grafting

植骨
  • 文章类型: Journal Article
    Hill-Sachs病变在肩部不稳定后很常见,和治疗方案各不相同,但包括保留或植入结构性骨移植物。无法通过replissage处理的大型Hill-Sachs病变难以管理,并且可能经常需要开放式手术方法来进行骨填充治疗。在这些手术中最大程度地可视化肱骨头的最佳方法尚不清楚。
    本研究的目的是比较采用改良后三角肌劈开入路与标准无手术脱位入路的肱骨头区域,特别注意在肩关节前不稳定的情况下,为了植骨的目的,接触Hill-Sachs病变。假设这两种方法都可以提供对模拟的Hill-Sachs病变的平等访问。
    对照实验室研究。
    四个人类尸体的肩膀安装在沙滩椅的位置。进行了改良的后三角肌分裂入路和非伸展性的胸前入路。在肱骨上模拟了典型的Hill-Sachs病变。进入肱骨头总表面积的百分比,包括接触模拟的希尔-萨克斯病变,是用三维数字化软件绘制的。
    三角洲方法提供了45%±15.2%的访问权限(范围,24%至58%)至肱骨头与22.2%±6.1%(范围,17%至30%),用于改良后三角肌分裂入路(P=0.057)。改良的后三角肌分裂入路可使模拟的Hill-Sachs病变达到100%,而非伸展性三角肌入路为0%。改良后三角肌分裂入路的进入关节面的角度是直接和垂直的。
    通过改良后三角肌劈开入路进入的肱骨头的总表面积比胸前入路要小;但是,可以通过改良的后三角肌分裂入路进入典型的Hill-Sachs病变的整个区域,而从标准的三角洲方法来看,该区域的可视化效果不佳。
    改良的后三角肌分裂入路为肱骨头提供了足够的通道,以便在肩前不稳定的情况下移植接合的Hill-Sachs病变。
    UNASSIGNED: Hill-Sachs lesions are common after shoulder instability, and treatment options vary but include remplissage or implantation of structural bone graft. Large Hill-Sachs lesions not addressed by remplissage are challenging to manage and may frequently require an open surgical approach for bone filling treatment options. The optimal approach to maximize visualization of the humeral head during these procedures remains unclear.
    UNASSIGNED: The purpose of this study was to compare the area of the humeral head accessed using a modified posterior deltoid split approach versus a standard deltopectoral approach without surgical dislocation, with particular attention to access of engaging Hill-Sachs lesions for the purpose of bone grafting in the setting of anterior shoulder instability. It was hypothesized that both approaches would provide equal access to a simulated Hill-Sachs lesion.
    UNASSIGNED: Controlled laboratory study.
    UNASSIGNED: Four human cadaveric shoulders were mounted in the beach-chair position. The modified posterior deltoid split approach and nonextensile deltopectoral approaches were performed. A typical Hill-Sachs lesion was simulated on the humeri. The percentage of the total surface area of the humeral head that was accessed, including access to the simulated Hill-Sachs lesion, was mapped using 3-dimensional digitizing software.
    UNASSIGNED: The deltopectoral approach provided 45% ± 15.2% access (range, 24% to 58%) to the humeral head versus 22.2% ± 6.1% (range, 17% to 30%) for the modified posterior deltoid split approach (P = .057). The modified posterior deltoid split approach enabled 100% access of the simulated Hill-Sachs lesion compared with 0% for the nonextensile deltopectoral approach. The angle of access to the articular surface was direct and perpendicular with the modified posterior deltoid split approach.
    UNASSIGNED: The overall surface area of the humeral head accessed via the modified posterior deltoid split approach was less compared with the deltopectoral approach; however, the entire area of a typical Hill-Sachs lesion was able to be accessed from the modified posterior deltoid split approach, whereas this area was not well visualized from the standard deltopectoral approach.
    UNASSIGNED: The modified posterior deltoid split approach provided sufficient access to the humeral head for the purposes of grafting an engaging Hill-Sachs lesion in the setting of anterior shoulder instability.
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  • 文章类型: Editorial
    有效治疗舟骨关节假性关节炎对于降低进展为潜在衰弱性舟骨骨不连晚期塌陷的风险至关重要,包括持续腕关节不稳定的并发症。退行性关节炎,运动范围减小,慢性疼痛,和功能损害。解剖和骨折相关的病理生理学都使患者容易患舟骨骨不连,包括有限的逆行血流,骨折位置,延迟适当的治疗。最近的研究已经证明了治疗舟骨骨不连的成功结果,采用非血管化自体骨移植,通常来自桡骨远端或髂棘,以及带蒂血管化或游离血管化自体移植物,愈合率从84%到100%不等。然而,这些手术治疗方案需要大量的解剖,引起人们对微创关节镜选择的关注。理论上,微创技术可以减轻舟骨骨折碎片的失活以及对关节囊等结构的损害,韧带,和已经非常脆弱的血液供应。使用鹰嘴骨移植物与微创关节镜技术和螺钉固定相结合是一种合理的选择,可以最大程度地减少舟骨骨折碎片的失活并最大程度地减少对重要软组织结构的损害。
    Effective treatment of scaphoid pseudoarthrosis is critical to reduce the risk of progression to the potentially debilitating scaphoid nonunion advanced collapse including complications of persistent wrist joint instability, degenerative arthritis, decreased range of motion, chronic pain, and functional impairment. Both anatomic and fracture-related pathophysiology predispose patients to scaphoid nonunion, including limited retrograde blood flow, fracture location, and delay of appropriate treatment. Recent studies have demonstrated successful outcomes in treatment of scaphoid nonunions, with non-vascularized bone autograft, commonly from distal radius or iliac crest, as well as pedicled vascularized or free vascularized autograft with union rates varying from 84% to 100%. However, these surgical treatment options require large dissection, prompting a focused interest in minimally invasive arthroscopic options. Theoretically, minimally invasive technique mitigates against devitalizing scaphoid fracture fragments as well as damage to structures such as the joint capsule, ligaments, and already highly tenuous blood supply. Use of olecranon bone graft in combination with a minimally invasive arthroscopic technique and screw fixation is a reasonable option to minimize devitalizing the scaphoid fracture fragments and minimize damage to important soft-tissue structures.
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  • 文章类型: Case Reports
    弗赖伯格的骨折是较小的跖骨头骨坏死,最常影响青春期女性。双侧弗赖伯格病很罕见,只有少数病例报告。保守管理是治疗的主体。手术治疗包括骨赘切除和松脱的软骨瓣,微骨折,矫正截骨,和跖骨头的清创术,经常有不可预测的结果。我们报告了一个罕见的病例,一个17岁的女孩患有双侧弗莱伯格病,她接受了自体基质诱导的软骨形成(AMIC)治疗。实现优异的放射学和功能结果。
    Freiberg\'s infraction is osteonecrosis of the lesser metatarsal heads, most commonly affecting adolescent females. Bilateral Freiberg\'s disease is rare, with only a few cases reported. Conservative management is the mainstay of treatment. Surgical management includes the excision of osteophytes and loose chondral flaps, microfracture, corrective osteotomy, and debridement of the metatarsal head, often with unpredictable outcomes. We report a rare case of a 17-year-old girl with bilateral Freiberg\'s disease who was treated with Autologous Matrix-Induced Chondrogenesis (AMIC), achieving excellent radiological and functional outcomes.
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  • 文章类型: Case Reports
    上颌骨后段的长期部分性牙本质症是一种具有挑战性的治疗方法,通常涉及广泛而侵入性的窦底增强术。各种方法已被用于窦底抬高,包括使用气球技术的液压应用。该病例报告描述了一种改良的膨胀技术,该技术使用Foley导管升高窦底,以在放置骨移植物和骨内植入物之前应用液压方法升高Schneiderian膜。在拔出的左第一上颌磨牙区域出现萎缩性牙槽脊高度为3.0mm的37岁男性患者。使用Foley导管的窦底抬高导致窦底抬高7mm,牙槽骨高度增加7.8mm。在假体植入物装载后的一年随访期间,患者无症状,植入物稳定。
    Longstanding partial edentulism in the posterior segment of the maxilla is a challenging treatment and typically involves extensive and invasive sinus floor augmentation. Various methods have been employed for sinus floor elevation, including the application of hydraulic pressure using the balloon technique. This case report describes a modified ballooning technique to elevate the sinus floor using a Foley catheter to apply the hydraulic pressure method to elevate the Schneiderian membrane prior to the placement of bone grafts and an endosseous implant in a 37-year-old male patient who presented with an atrophic alveolar ridge height of 3.0 mm in the area of the extracted left first maxillary molar. Sinus floor elevation using the Foley catheter led to a sinus floor elevation of 7 mm and a gain in alveolar bone height of 7.8 mm. The patient was asymptomatic with a stable implant during the one-year follow-up period after prosthetic implant loading.
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  • 文章类型: Journal Article
    暂无摘要。
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  • 文章类型: Journal Article
    直接种植牙的放置本质上显示了牙弓间隙,这可能会损害植入物的骨整合。已经使用了几种接枝材料来克服这个问题。在可用的材料中,骨水泥的使用在口腔种植学中相对较新。这项研究旨在检查有关骨水泥在立即放置牙种植体中的使用的现有文献,并评估其在口腔种植学中的潜力。
    综合证据,评价骨水泥对种植体稳定性和拔牙后立即放置的牙种植体的骨与种植体接触(BIC)的影响。
    在PubMed中进行了系统搜索,Medline,和ScienceDirect使用相关搜索词从开始到2021年9月发表的相关研究。在1624年的研究中,本系统综述选择了4名。
    四项研究中的三项得出的结论是,骨水泥增强了植入物的稳定性和/或BIC,同时改善了直接牙科植入物周围的骨骼质量和/或数量。一篇文章得出的结论仍然犹豫不决。由于存在实质性异质性,无法进行荟萃分析。
    骨水泥是一种有前途的治疗替代品,因为它可以增强即刻牙科植入物的植入物稳定性和/或BIC。尽管如此,需要进一步的前瞻性人体临床试验来确定其临床有效性,并得出明确的结论以推荐其临床应用。
    UNASSIGNED: The placement of immediate dental implants intrinsically displays crestal gaps, which may compromise implant osseointegration. Several grafting materials have been used to overcome this issue. Of the available materials, the use of bone cement is relatively new in oral implantology. This study aimed to examine the available literature on the utilization of bone cements in immediate placement of dental implants and assess its potential in oral implantology.
    UNASSIGNED: To synthesize evidence for appraising the impact of bone cements on implant stability and bone-to-implant contact (BIC) of dental implants placed immediately after extraction in humans and animals after 3 months of healing from tooth extraction.
    UNASSIGNED: A systematic search was conducted in PubMed, Medline, and ScienceDirect for relevant studies published from inception to September 2021 using relevant search terms. Of the 1624 studies, 4 were selected for this systematic review.
    UNASSIGNED: Three of the four studies concluded that bone cements enhanced implant stability and/or BIC with better quality and/or quantity of bone surrounding the immediate dental implant. The conclusion drawn by one article remained indecisive. Meta-analysis could not be performed owing to the presence of substantial heterogeneity.
    UNASSIGNED: Bone cement is a promising treatment alternative as it augments implant stability and/or BIC in immediate dental implants. Nonetheless, further prospective human clinical trials are required to establish its clinical effectiveness and arrive at a definitive conclusion to recommend its clinical use.
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  • 文章类型: Journal Article
    目的:本研究旨在探讨骨移植对股骨干骨不连交换钉(EN)治疗中骨愈合的影响。
    方法:本研究共纳入26例患者(16例男性)。患者的平均年龄为36.1±9.3。8例患者(植骨组)采用植骨,18例患者进行EN,不进行植骨(无植骨组)。病因学,骨折类型,location,并对初次受伤时的骨折分类进行了评估。还注意到指甲的复位类型(打开或闭合)和锁定状态。记录骨不连类型。在植骨组中,7例患者使用自体骨移植物,1例患者使用合成骨移植物。在EN之后,骨愈合的存在和持续时间,并分析每组指甲直径的增加情况并进行比较。
    结果:植骨组和无植骨组的结合率分别为100%和94.4%,分别。两组之间的平均结合期不显著(22.5个月和16.5个月,分别)。植骨组钉直径平均增加1.88mm,非植骨组增加2.00mm(p>0.05)。
    结论:这项研究表明,在股骨干骨不连的治疗中,通过使用较大直径的钉,有或没有植骨,可以实现较高的愈合率。植骨对愈合率和愈合时间没有显著影响。
    OBJECTIVE: This study aims to investigate the effect of bone grafting on the bone union in exchange nailing (EN) for the treatment of femoral shaft nonunions.
    METHODS: A total of 26 patients (16 male) were included in this study. The mean age of the patients was 36.1±9.3. Bone grafts were used in 8 patients (bone graft group), and EN was performed without bone grafting (no bone graft group) in 18 patients. Etiology, fracture type, location, and classification of the fractures at the time of initial injury were evaluated. The reduction type (open or closed) and locking status of the nails were also noted. Nonunion types were recorded. In the bone grafting group, iliac bone autografts were used in seven patients and a synthetic bone graft was used in one patient. Following EN, the presence and duration of bone union, and the increase in the nails\' diameter were analyzed for each group and compared.
    RESULTS: Union rates were 100% and 94.4% in bone grafting and no bone grafting groups, respectively. The mean union period was not significant between the groups (22.5 and 16.5 months, respectively). The mean increase in the nail diameter was 1.88 mm in the bone graft group and 2.00 mm in the no bone graft group (p>0.05).
    CONCLUSIONS: This study demonstrated that high union rates can be achieved with EN by means of using larger diameter nails with or without bone grafting in the management of femoral shaft nonunions, and bone grafting had no significant effect on union rates and periods.
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  • 文章类型: Journal Article
    背景:肩袖完整的肩关节关节骨性关节炎伴严重后盂骨丢失可以通过反向肩关节成形术进行处理,但需要进行侧位和版本校正以避免潜在的并发症,比如不稳定,开槽和植入失败。肱骨头自体移植的角度骨移植可以提供持久的关节盂骨原料,但结果喜忧参半。这项研究的目的是评估接受角度肱骨头自体移植治疗严重逆行的患者的患者报告和客观结果以及并发症和失败率。
    方法:在我们机构的2018年11月至2022年2月期间,所有患者均接受了带角度肱骨头自体移植和StrykerTornier长中央后基板的原发性RSA治疗严重的关节盂骨丢失,其中肩袖完整。包括主要诊断为骨关节炎和术前关节盂逆行≥30°的个体。正在进行修订程序的患者,计划中的两阶段关节成形术被排除.术前和术后活动范围的差异,并评估了患者报告的结局.术中并发症,术后并发症,并对再手术率进行了分析。
    结果:23例患者(61%为男性)共24肩,包括平均年龄65.6岁.术前平均逆行37.4°(范围:30°-51°)。平均随访时间为2.9年(范围:2-4.3年)。在屈曲方面发现了显著的改善,绑架,和外部旋转。患者报告的主观结果非常好,平均ASES评分为93.6,平均SSV为93.8%。16个(67%)的肩膀接受了术后CT扫描,发现全部合并。并发症包括1例肩关节血肿需切开引流而未翻修。11个月时下关节盂螺钉的创伤后骨折,需要用植骨翻修RSA。没有因部件松动而发生无创伤的灾难性故障。
    结论:这项研究表明,使用斜角肱骨头植骨是一种很好的解决方案,可以用于后部关节盂骨丢失的版本矫正。ROM中报告了重大改进,疼痛,和主观功能得分,在早期随访中具有优异的移植物结合率和低并发症。进一步的工作应侧重于收集更高水平的证据,详细的影像学分析和探索肱骨头植骨的其他适应症。
    BACKGROUND: Severe posterior glenoid bone loss with glenohumeral osteoarthritis with an intact rotator cuff can be managed with reverse shoulder arthroplasty but requires lateralization and version correction to avoid potential complications, such as instability, notching and implant failure. Angled bone grafting with humeral head autograft can provide durable glenoid bone stock, but results have been mixed. The purpose of this study was to evaluate patient-reported and objective outcomes as well as complication and failure rates for patients who underwent angled humeral head autografting for severe retroversion.
    METHODS: All patients who underwent a primary RSA with angled humeral head autograft and Stryker Tornier long central post baseplate for severe glenoid bone loss in the setting of glenohumeral osteoarthritis with an intact rotator cuff at our institution between November 2018 and February of 2022 were identified. Individuals with a primary diagnosis of osteoarthritis and preoperative glenoid retroversion of ≥30° were included. Patients undergoing revision procedures, planned two-stage arthroplasty were excluded. Differences in pre- and postoperative range of motion, as well as patient-reported outcomes were assessed. Intraoperative complications, postoperative complications, and re-operation rates were analyzed.
    RESULTS: A total of 24 shoulders in 23 patients (61% male), with a mean age of 65.6 years were included. Average preoperative retroversion was 37.4° (range: 30° - 51°). Mean follow-up was 2.9 years (range: 2 - 4.3 years). Significant improvements were found in flexion, abduction, and external rotation. Patient-reported subjective outcomes were excellent, with average ASES score of 93.6 and average SSV 93.8%. Sixteen (67%) shoulders received postoperative CT scans and all were found to have incorporated. Complications included one shoulder hematoma requiring incision and drainage without revision, and a post-traumatic fracture of the inferior glenoid screw at 11 months, requiring revision RSA with bone grafting. No atraumatic catastrophic failures occurred due to component loosening.
    CONCLUSIONS: This study suggests that using angled humeral head bone grafting is a good solution for version correction in extreme posterior glenoid bone loss. Significant improvements are reported in ROM, pain, and subjective functional scores, with excellent graft incorporation rates and a low complication profile at early follow-up. Further work should focus on gathering higher levels of evidence, detailed radiographic analyses and exploring humeral head bone grafting for other indications.
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  • 文章类型: Journal Article
    在口腔种植学中,骨缺损患者在植入前,外科医生经常需要改善牙槽骨质量和体积。而钛网引导骨再生(GBR)是临床“金标准”的骨增强,植入前的网状物去除存在一个缺点。这项研究探索了可生物降解的支架作为替代方案。该研究调查了定制骨移植支架的各种成分对体外增殖和成骨分化过程的影响。板(10×10×0.5毫米)是由聚丙交酯(PLA),含15%羟基磷灰石纳米粒子的PLA(PLA/HA),和聚丙交酯与乙醇酸共聚物(PLGA60:40和85:15)。牙龈成纤维细胞评估了实验样品在低葡萄糖培养基中对增殖和成骨分化的影响。诱导成骨分化,茜素红染色通过分光光度法测定细胞外基质钙化。在培养过程中,牙龈成纤维细胞沿支架边缘活跃增殖。尽管细胞在实验样本中增殖,率低于对照细胞。PLA/HA显示更高的茜素红染色强度,表明基质钙化增强。实验样品(PLA,PLA/HA,PLGA85:15,PLGA60:40)以低于对照的速率支持细胞增殖。PLA/HA显示基质钙化增加。可生物降解的膜是无毒的,提示骨骼增强的潜力。
    In oral implantology, surgeons often confront the need to improve alveolar bone quality and volume before implantation in patients with bone defects. While Guided Bone Regeneration (GBR) with titanium meshes is a clinical \"gold standard\" for bone augmentation, mesh removal pre-implantation presents a drawback. This study explores biodegradable scaffolds as an alternative. The research investigates the impact of various compositions of customized bone grafting scaffolds on proliferation and osteogenic differentiation processes in vitro. Plates (10 x 10 x 0.5 mm) were fabricated from polylactide (PLA), PLA with 15% hydroxyapatite nanoparticles (PLA/HA), and polylactide with glycolic acid copolymers (PLGA 60:40 and 85:15). Gingival fibroblasts assessed the influence of experimental samples on proliferation and osteogenic differentiation in a low-glucose medium. Osteogenic differentiation was induced, and alizarin red staining measured extracellular matrix calcification via spectrophotometry. Active proliferation of gingival fibroblasts occurred along scaffold edges during cultivation. Although cells proliferated with experimental samples, rates were lower than control cells. PLA/HA showed higher alizarin red staining intensity, indicating enhanced matrix calcification. Experimental samples (PLA, PLA/HA, PLGA 85:15, PLGA 60:40) supported cell proliferation at lower rates than control. PLA/HA demonstrated increased matrix calcification. Biodegradable membranes were non-toxic, suggesting potential for bone augmentation.
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  • 文章类型: Journal Article
    双侧唇腭裂(BCLP)患者的牙槽骨移植(ABG)提供了重建挑战。我们提出了一种新的技术,将自体骨移植物(ICBG)与重组人骨形态发生蛋白2(rhBMP-2)和细胞骨基质(CBM)结合起来,用于BCLP患者的ABG。90%的患者发生完全骨填充,100%有双侧犬科动物喷发。没有患者需要重复ABG,无明显并发症报告。肺泡裂隙体积显著减少,改善75.87%。用rhBMP-2和CBM进行自体ICBG的ABG是BCLP患者的有效技术。
    Alveolar bone grafting (ABG) in bilateral cleft lip and palate (BCLP) patients provides a reconstructive challenge. We present a novel technique of combining autologous iliac crest bone graft (ICBG) with recombinant human bone morphogenic protein 2 (rhBMP-2) and cellular bone matrix (CBM) for ABG in BCLP patients. Complete bone fill occurred in 90% of patients, with 100% having bilateral canine eruption. No patients required repeat ABG, and no significant complications were reported. The alveolar cleft gap volume significantly decreased with an improvement of 75.87%. ABG with autologous ICBG with rhBMP-2 and CBM is an effective technique for patients with BCLP.
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