这项研究的目的是使用25,486个基因型的捷克荷斯坦进行构象性状的全基因组关联研究(GWAS),每个基因型有35,227个常见SNP。线性性状记录是在1995年至2020年之间收集的。包含来自多个国家评估(MACE)的Interbull信息,这些公牛大多在国外有女儿记录。当使用Bonferroni校正时,显著或接近显著阈值的SNP数量为BTA4的低乳容量复合,脚和腿复合BTA21,总分BTA10,身高BTA24,身体深度BTA6,棱角BTA20,乳房前附着BTA10.没有Bonferroni修正,显著或接近显著的SNP总数为32.SNP位于BTA1,2,4,5,6,7,8,18,22,25,26,28上,用于乳制品能力复合材料,BTA15,21用于脚和腿复合材料,BTA10为总分,BTA24身材,BTA6,23车身深度,BTA20角度,BTA2后倾角,BTA9,10后腿后视图,BTA2,19后腿侧视图,BTA10前乳房附件,BTA2乳房深度,BTA10后乳房高度,BTA12中央对齐,BTA24后奶嘴放置,BTA8,29后乳房宽度。研究结果为改善荷斯坦人群的身体形态和适应性提供了生物学信息。
The aim of this study was a genome-wide association study (GWAS) on conformation traits using 25,486 genotyped Czech Holsteins, with 35,227 common SNPs for each genotype. Linear trait records were collected between 1995 and 2020. The Interbull information from Multiple Across Country Evaluation (MACE) was included for bulls that mostly had daughter records in a foreign country. When using the Bonferroni correction, the number of SNPs that were either significant or approached the significance threshold was low-dairy capacity composite on BTA4, feet and legs composite BTA21, total score BTA10, stature BTA24, body depth BTA6, angularity BTA20, fore udder attachment BTA10. Without the Bonferroni correction, the total number of significant or near of significance SNPs was 32. The SNPs were localized on BTA1,2,4,5,6,7,8,18,22,25,26,28 for dairy capacity composite, BTA15,21 for feet and legs composite, BTA10 for total score, BTA24 stature, BTA6,23 body depth, BTA20 angularity, BTA2 rump angle, BTA9,10 rear legs rear view, BTA2,19 rear legs side view, BTA10 fore udder attachment, BTA2 udder depth, BTA10 rear udder height, BTA12 central alignment, BTA24 rear teat placement, BTA8,29 rear udder width. The results provide biological information for the improvement of body conformation and fitness in the Holstein population.