背景:维持静态平衡在日常生活中是相关且常见的,它取决于正确的节间协调。姿势能力的改变或减少与跌倒风险增加有关。帕金森病(pwPD)患者出现运动症状,影响稳定姿势的维持。这项研究的目的是了解姿势摇摆的节间变化,并应用趋势变化分析来揭示pwPD和健康成年人之间的不同运动策略。
方法:总共,61名健康参与者,40年轻(YO),21名老参与者(OP),和29pwPD(13在停药期间,PDoff;23在用药期间,PDon)被包括在内。作为短物理性能电池的一部分,参与者安静地站了10s。头部的惯性测量单元(IMU);胸骨,和腰椎区域用于提取姿势参数,并进行趋势变化分析(TCA)以进行组间比较.
目的:本研究旨在探索TCA在使用IMU评估姿势稳定性方面的潜在应用,其次,在神经系统疾病的背景下采用这种分析,特别是帕金森病。
结果:传感器位置的比较显示,头部之间存在显着差异,胸骨和骨盆几乎所有的参数和队列。当比较PDon和PDoff时,TCA显示任何其他参数均未发现的差异。
结论:虽然所有参数都可以区分传感器位置,除了TCA允许区分PD开/关之外,没有发现组差异.TCA评估疾病进展的潜力,在未来的研究中,应该探索对治疗的反应,甚至是前驱PD阶段。
背景:研究程序已获得基尔大学医学院伦理委员会的批准(D438/18)。该研究在德国临床试验注册(DRKS00022998)中注册。
BACKGROUND: Maintaining static balance is relevant and common in everyday life and it depends on a correct intersegmental coordination. A change or reduction in postural capacity has been linked to increased risk of falls. People with Parkinson\'s disease (pwPD) experience motor symptoms affecting the maintenance of a stable posture. The aim of the study is to understand the intersegmental changes in postural sway and to apply a trend change analysis to uncover different movement strategies between pwPD and healthy adults.
METHODS: In total, 61 healthy participants, 40 young (YO), 21 old participants (OP), and 29 pwPD (13 during medication off, PDoff; 23 during medication on, PDon) were included. Participants stood quietly for 10 s as part of the Short Physical Performance Battery. Inertial measurement units (IMU) at the head, sternum, and lumbar region were used to extract postural parameters and a trend change analysis (TCA) was performed to compare between groups.
OBJECTIVE: This study aims to explore the potential application of TCA for the assessment of postural stability using IMUs, and secondly, to employ this analysis within the context of neurological diseases, specifically Parkinson\'s disease.
RESULTS: Comparison of sensors locations revealed significant differences between head, sternum and pelvis for almost all parameters and cohorts. When comparing PDon and PDoff, the TCA revealed differences that were not seen by any other parameter.
CONCLUSIONS: While all parameters could differentiate between sensor locations, no group differences could be uncovered except for the TCA that allowed to distinguish between the PD on/off. The potential of the TCA to assess disease progression, response to treatment or even the prodromal PD phase should be explored in future studies.
BACKGROUND: The research procedure was approved by the ethical committee of the Medical Faculty of Kiel University (D438/18). The study is registered in the German Clinical Trials Register (DRKS00022998).