未经证实:血泡状动脉瘤(BBA)是一种罕见且特殊类型的颅内动脉瘤,破裂率极高,发病率,死亡率,和复发。Willis覆盖支架(WCS)是一种专门设计用于治疗颅内复杂动脉瘤的新设备。然而,WCS治疗BBA的有效性和安全性仍存在争议.因此,需要高水平的证据来证明WCS治疗的有效性和安全性.
UNASSIGNED:在Medline中使用全面的文学搜索进行了系统的文献综述,Embase,和WebofScience数据库,以确定与BBA的WCS治疗相关的研究。然后进行荟萃分析,以纳入疗效和安全性结果,包括术中情况,术后情况,和后续数据。
UASSIGNED:8项非比较研究包含104例患者和106例BBA,符合纳入标准。在术中情况下,技术成功率为99.5%[95%置信区间(CI),0.958,1.000],完全闭塞率为98.2%(95%CI,0.925,1.000),侧支闭塞率为4.1%(95%CI,0.001,0.114)。9.2%(95%CI,0.000,0.261)和0.1%(95%CI,0.000,0.032)的患者发生血管痉挛和夹层,分别。在手术后的情况下,再出血和死亡率分别为2.2%(95%CI,0.000,0.074)和1.5%(95%CI,0.000,0.062),分别。在后续数据中,在0.3%(95%CI,0.000,0.042)和9.1%(95%CI,0.032,0.168)的患者中,分别。最终,95.7%(95%CI,0.889,0.997)的患者预后良好。
UNASSIGNED:Willis覆膜支架可安全有效地应用于BBA治疗。研究结果为今后的临床试验提供了参考。必须进行精心设计的前瞻性队列研究以进行验证。
UNASSIGNED: Blood blister-like aneurysm (BBA) is a rare and special type of intracranial aneurysm with extremely high rates of rupture, morbidity, mortality, and recurrence. Willis Covered Stent (WCS) is a new device that is specifically designed for the treatment of intracranial complex aneurysms. However, the efficacy and safety of WCS treatment for BBA remain controversial. Thus, a high level of evidence is required to prove the efficacy and safety of WCS treatment.
UNASSIGNED: A systematic literature review was performed using a comprehensive literary search in Medline, Embase, and Web of Science databases to identify studies related to WCS treatment for BBA. A meta-analysis was then conducted to incorporate the efficacy and safety outcomes, including intraoperative situation, post-operative situation, and follow-up data.
UNASSIGNED: Eight non-comparative studies containing 104 patients with 106 BBAs met the inclusion criteria. In the intraoperative situation, the technical success rate was 99.5% [95% confidence interval (CI), 0.958, 1.000], the complete occlusion rate was 98.2% (95% CI, 0.925, 1.000), and the side branch occlusion rate was 4.1% (95% CI, 0.001, 0.114). Vasospasm and dissection occurred in 9.2% (95% CI, 0.000, 0.261) and 0.1% (95% CI, 0.000, 0.032) of the patients, respectively. In the post-operative situation, the rebleed and mortality rates were 2.2% (95% CI, 0.000, 0.074) and 1.5% (95% CI, 0.000, 0.062), respectively. In the follow-up data, recurrence and parent artery stenosis occurred in 0.3% (95% CI, 0.000, 0.042) and 9.1% (95% CI, 0.032, 0.168) of the patients, respectively. Ultimately, 95.7% (95% CI, 0.889, 0.997) of the patients had a good outcome.
UNASSIGNED: Willis Covered Stent could be effectively and safely applied for BBA treatment. The results provide a reference for clinical trials in the future. Well-designed prospective cohort studies must be conducted for verification.