背景:我们探讨了脑小血管疾病(cSVD)亚型中钆螯合物(Ktrans)的血脑屏障(BBB)泄漏率和BBB水交换率(kw)的变化。
方法:三十种零星的cSVD,40伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病(CADASIL),与40名健康个体平行研究了13名与高温需求因子A丝氨酸肽酶1(HTRA)相关的cSVD受试者。受试者接受临床,认知,MRI评估。
结果:在CADASIL中,Ktrans没有区别,但是在多个大脑区域观察到较低的千瓦。在零星的CSVD中,千瓦没有区别,但是在整个大脑和正常的白质中发现了更高的Ktrans。在HTRA1相关的cSVD中,观察到整个大脑中的Ktrans较高,而多个大脑区域中的kw较低。在每个患者组中,BBB测量值的改变与病变负荷或临床严重程度相关.
结论:在cSVD亚型中,观察到kw和Ktrans的明显变化。Ktrans和kw的组合可以描述异质性BBB功能障碍。
结论:我们在cSVD的三种亚型中测量了BBB向基于g的造影剂(Ktrans)的渗漏和跨BBB的水交换速率(kw)。CADASIL的特点是低千瓦,与HTRA1相关的cSVD表现出更高的Ktrans和更低的kw,而零星的cSVD的特点是Ktrans较高。cSVD亚型之间的kw和Ktrans有明显的变化,表明BBB功能障碍的异质性。
We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (Ktrans) and BBB water exchange rate (kw) varied in cerebral small vessel disease (cSVD) subtypes.
Thirty sporadic cSVD, 40 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and 13 high-temperature requirement factor A serine peptidase 1 (HTRA) -related cSVD subjects were investigated parallel to 40 healthy individuals. Subjects underwent clinical, cognitive, and MRI assessment.
In CADASIL, no difference in Ktrans, but lower kw was observed in multiple brain regions. In sporadic cSVD, no difference in kw, but higher Ktrans was found in the whole brain and normal-appearing white matter. In HTRA1-related cSVD, both higher Ktrans in the whole brain and lower kw in multiple brain regions were observed. In each patient group, the altered BBB measures were correlated with lesion burden or clinical severity.
In cSVD subtypes, distinct alterations of kw and Ktrans were observed. The combination of Ktrans and kw can depict the heterogeneous BBB dysfunction.
We measured BBB leakage to gadolinium-based contrast agent (Ktrans) and water exchange rate (kw) across BBB in three subtypes of cSVD. CADASIL is characterized by lower kw, HTRA1-related cSVD exhibits both higher Ktrans and lower kw, while sporadic cSVD is distinguished by higher Ktrans. There are distinct alterations in kw and Ktrans among subtypes of cSVD, indicating the heterogeneous nature of BBB dysfunction.