背景:在慢性疲劳综合征/肌痛性脑脊髓炎(ME/CFS)中,活动和参与的能力非常有限。疾病的定义非常广泛,考虑到缺乏最佳治疗的证据,与类似综合征相比,在生物心理社会视角下了解ME/CFS特异性是很重要的.目的是研究诊断为ME/CFS的患者与症状相似但未诊断为ME/CFS的患者对自我感知的身体活动水平的差异,工作能力,焦虑/抑郁,和健康相关的生活质量。
方法:这是一项临床横断面研究,数据来自邮寄问卷。在诊断为ME/CFS的患者(n=205)和症状相似但未诊断的患者(n=57)之间比较了以下变量:体力活动水平,工作能力指数(WAI),医院焦虑抑郁量表(HAD-A/HAD-D),和RAND-36物理功能,由于身体健康问题造成的角色限制,由于个人或情绪问题的角色限制,社会功能,能量/疲劳,身体疼痛,情绪幸福,和一般的健康观念。卡方检验(标称数据),Mann-WhitneyU测试,采用学生t检验和回归分析进行数据分析。
结果:与症状相似但未被诊断为ME/CFS的组相比,被诊断为ME/CFS的组的身体和精神运动能力受损。通过RAND-36较低的身体角色功能指数显示,社会功能,能源,疼痛加重,整体健康状况较差(p≤0.05)。相比之下,每周体力活动水平没有显著的组间差异,工作能力,焦虑/抑郁,和RAND-36情感角色限制和幸福感。
结论:我们的结果表明,诊断为ME/CFS的患者的特征是身体或精神活动能力受损,更严重的疼痛,与症状相似但未确定ME/CFS诊断的个体相比,整体健康状况较差。当关注患者在能量水平管理方面的自我护理时,结果可能会被谨慎地解释为支持。然而,结果必须在未来的研究中得到验证。
In chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS), the capacity for activity and participation is strongly limited. The disease definition is very broad, and considering the lack of evidence for best treatment, it is important to understand what is ME/CFS-specific in the biopsychosocial perspective in comparison with similar syndromes. The objective was to study the difference between those diagnosed with ME/CFS and those with similar symptoms but no ME/CFS diagnosis for self-perceived level of physical activity, work ability, anxiety/depression, and health-related quality of life.
This was a clinical cross-sectional study with data collected from mailed questionnaires. The following variables were compared between patients diagnosed with ME/CFS (n = 205) and those with similar symptoms but no diagnosis (n = 57); level of physical activity, Work ability index (WAI), Hospital anxiety and depression scale (HAD-A/HAD-D), and RAND-36 Physical functioning, Role limitations due to physical health problems, Role limitations due to personal or emotional problems, Social functioning, Energy/fatigue, Bodily pain, Emotional well-being, and General health perceptions. The Chi-squared test (nominal data), the Mann-Whitney U test, the Student\'s t test and regression analysis were used to analyze the data.
The group diagnosed with ME/CFS had a more impaired physical and mental exertion ability as compared to the group that had similar symptoms but was not diagnosed with ME/CFS, shown by a RAND-36 lower index of physical role functioning, social functioning, energy, worse pain and poorer overall health (p ≤ 0.05). In contrast, no significant group differences emerged for weekly level of physical activity, work ability, anxiety/depression, and RAND-36 Emotional role limitation and well-being.
Our results indicate that those with a diagnosis of ME/CFS are characterized by an impaired ability for physical or mental exertion, worse pain, and poorer overall health as compared to individuals with similar symptoms but for whom ME/CFS-diagnosis was not established. The results may be cautiously interpreted as support when focusing on patients\' self-care in terms of management of energy levels. The results must however be verified in future studies.