■这项研究的目的是定义乳头周围视网膜神经纤维层(pRNFL)的正常范围,黄斑神经节细胞层(mGCL),食蟹猴的黄斑内网状层(MIPL)厚度,并探索它们与年龄的相互关系和相关性,屈光不正,和轴向长度(AL)。
■在这项横断面研究中,我们测量了生物特征和屈光参数,357只健康食蟹猴的pRNFL/mGCL/mIPL厚度。猴子按年龄和等效球形(SE)分为几组。采用相关和回归分析探讨pRNFL与mGCL/mIPL厚度的关系,以及它们与上述参数的相关性。
■平均年龄,SE,AL为14.46±6.70岁,-0.96±3.23屈光度(D),和18.39±1.02毫米,分别。平均全局pRNFL厚度为95.06±9.42µm(范围=54-116µm),下象限的值最高,其次是上级,temporal,和鼻象限(P<0.001)。pRNFL厚度与年龄(r=0.218,P<0.001)和AL(r=0.364,P<0.001)呈正相关,与SE呈负相关(r=-0.270,P<0.001)。在其他象限中,pRNFL厚度与年龄和AL呈负相关,但积极与SE。在多元线性回归模型中,调整性别和AL,年龄(β=-0.350,P<0.001),SE(β=0.206,P<0.001)与全局pRNFL厚度显着相关。在调整了年龄之后,性别,SE,AL,pRNFL厚度与mGCL(β=0.433,P<0.001)和mIPL厚度(β=0.465,P<0.001)呈正相关。
■pRNFL/mGCL/mIPL厚度分布及其与年龄的关系,AL,食蟹猴的SE与人类高度可比,这表明食蟹猴是眼科研究中很有价值的动物模型。
UNASSIGNED: The purpose of this study was to define the normal range of peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer (mGCL), and macular inner plexiform layer (mIPL) thickness in cynomolgus macaques, and explore their inter-relationship and correlation with age, refractive errors, and axial length (AL).
UNASSIGNED: In this cross-sectional study, we measured biometric and refractive parameters, and pRNFL/mGCL/mIPL thickness in 357 healthy cynomolgus macaques. Monkeys were divided into groups by age and spherical equivalent (SE). Correlation and regression analyses were used to explore the relationship between pRNFL and mGCL/mIPL thickness, and their correlation with the above parameters.
UNASSIGNED: The mean age, SE, and AL were 14.46 ± 6.70 years, -0.96 ± 3.23 diopters (D), and 18.39 ± 1.02 mm, respectively. The mean global pRNFL thickness was 95.06 ± 9.42 µm (range = 54-116 µm), with highest values in the inferior quadrant, followed by the superior, temporal, and nasal quadrants (P < 0.001). Temporal pRNFL thickness correlated positively with age (r = 0.218, P < 0.001) and AL (r = 0.364, P < 0.001), and negatively with SE (r = -0.270, P < 0.001). In other quadrants, pRNFL thickness correlated negatively with age and AL, but positively with SE. In the multivariable linear regression model, adjusted for sex and AL, age (β = -0.350, P < 0.001), and SE (β = 0.206, P < 0.001) showed significant associations with global pRNFL thickness. After adjusting for age, sex, SE, and AL, pRNFL thickness positively correlated with mGCL (β = 0.433, P < 0.001) and mIPL thickness (β = 0.465, P < 0.001).
UNASSIGNED: The pRNFL/mGCL/mIPL thickness distribution and relationship with age, AL, and SE in cynomolgus macaques were highly comparable to those in humans, suggesting that cynomolgus monkeys are valuable animal models in ophthalmic research.