未经证实:阻塞性睡眠呼吸暂停(OSA)在肥厚型心肌病(HCM)患者中很常见,并且与HCM患者不良预后有关。然而,没有公认的警告特征来帮助识别HCM患者的OSA.
UNASSIGNED:连续纳入2015年1月至2019年12月在南昌大学第二附属医院接受多导睡眠图(PSG)检查的71例HCM患者和49例高血压(HTN)患者作为对照组。分析比较合并OSA和未合并OSA的HCM患者的特征。
未经证实:共有37例(52%)HCM患者和25例(51%)HTN患者被诊断为OSA。高体重指数(BMI)(OR=1.228,95%CI:1.032,1.461,P=0.020)和低估计肾小球滤过率(eGFR)(OR=0.959,95%CI:0.931,0.989,P=0.007)与HCM患者OSA的发生独立相关。分别。在HCM患者中,高BMI和低eGFR对OSA风险的影响表现为多重交互作用(OR:6.050,95%CI:1.598,22.905,P=0.008)。加性相互作用分析进一步表明,由于BMI和eGFR之间的加性相互作用,70.1%的HCM患者发展为OSA。与BMI(曲线下面积0.683,P=0.008)或eGFR(曲线下面积0.700,P=0.004)相比,BMI和eGFR(受试者工作特征分析曲线下面积0.785;P=0.000038)均显着增强了HCM患者OSA的识别能力,分别。
UNASSIGNED:高BMI或低eGFR与HCM患者OSA的发生独立相关,BMI和eGFR之间的乘法和加性相互作用增加了HCM患者OSA的识别能力。
UNASSIGNED: Obstructive sleep apnea (OSA) is common in hypertrophic cardiomyopathy (HCM) patients and is related to worse adverse prognosis in HCM patients. However, there are no acknowledged warning characteristics to help to identify OSA in HCM patients.
UNASSIGNED: Seventy-one HCM patients and forty-nine hypertensive (HTN) patients as control group underwent polysomnography (PSG) examination at the Second Affiliated Hospital of Nanchang University from January 2015 to December 2019 patients were consecutively enrolled. The characteristics were analyzed and compared between HCM patients with OSA and without OSA.
UNASSIGNED: A total of 37 (52%) HCM patients and 25 (51%) HTN patients were diagnosed with OSA. High body mass index (BMI) (OR = 1.228, 95% CI: 1.032,1.461, P = 0.020) and low estimated glomerular filtration rate (eGFR) (OR = 0.959, 95% CI: 0.931,0.989, P = 0.007) independently correlated with the occurrence of OSA in HCM patients, respectively. Multiplicative interaction was shown between high BMI and low eGFR on the risk of OSA in HCM patients (OR: 6.050, 95% CI: 1.598, 22.905, P = 0.008). The additive interaction analysis further suggested that 70.1% of HCM patients developed OSA due to the additive interaction between BMI and eGFR. The identification ability of OSA in HCM patients was significantly enhanced by using both BMI and eGFR (area under receiver-operating characteristic analysis curve 0.785; P = 0.000038) as compared with BMI (area under curve 0.683, P = 0.008) or eGFR (area under curve 0.700, P = 0.004), respectively.
UNASSIGNED: High BMI or low eGFR independently related to the occurrence of OSA in HCM patients, and the multiplicative and additive interactions between BMI and eGFR increased the identification ability of OSA in HCM patients.