未经证实:先兆子痫对肾和肝功能有有害影响,导致各种生化测试的改变。因此,这项研究的主要目的是评估一些肝肾生化检查在子痫前期诊断中的作用。
UNASSIGNED:对共有126名妊娠20周后在冈达尔大学综合专科医院就诊的孕妇进行了横断面比较研究。将参与者分为病例组和对照组。病例组包括63名先兆子痫妇女,而对照组有63岁和孕周相匹配的正常孕妇。每个参与者,收集了三毫升的血液,血清部分被分离,并使用Humastar800化学分析仪对选定的生化测试进行测量。使用SPSS20进行独立的t检验和接收器操作特征,以比较和确定研究组之间不同生化测试的诊断价值。
未经批准:母体血清转氨酶,总胆红素,肌酐,与血压正常的孕妇相比,先兆子痫妇女的尿素水平均显着升高。受试者工作特征图显示,血清天冬氨酸氨基转移酶水平的曲线下面积为0.89(95%CI:0.84-0.95),可以在≥58.5U/l的临界值下区分先兆子痫患者和正常血压孕妇,敏感性为74.6%,87.3%的特异性,诊断准确率为80.9%。血清肌酐水平的曲线下面积为0.91(95%CI:0.86-0.96),能够在临界值≥0.90mg/dl时指示先兆子痫,敏感性为77.8%,特异性为85.7%。
未经批准:血清转氨酶升高,总胆红素,肌酐,孕妇的尿素水平可能表明先兆子痫的发展,需要调查。在生化测试中,血清肌酐水平是子痫前期的最佳诊断指标,其次是血清天冬氨酸转氨酶水平。
UNASSIGNED: Preeclampsia has a deleterious effect on renal and liver function, which results in alterations of various biochemical tests. Therefore, the main aim of this study was to evaluate the role of some hepatic and renal biochemical tests in the diagnosis of preeclampsia.
UNASSIGNED: A comparative cross-sectional study was carried out on a total of 126 pregnant women after 20th week of gestation who attended at the University of Gondar Comprehensive Specialized Hospital. The participants were divided into two groups as cases and controls. The case group consisted of 63 preeclamptic women, whereas the control group had 63 age and gestational week matched normotensive pregnant women. From each participant, three milliliters of blood was collected, the serum part was separated, and selected biochemical tests were measured using Humastar 800 chemistry analyzer. An independent t-test and receiver operating characteristics were done using SPSS 20 for comparison and diagnostic value determination of different biochemical tests between the study groups.
UNASSIGNED: The maternal serum aminotransferases, total bilirubin, Creatinine, and Urea levels were all significantly elevated in preeclamptic women compared to normotensive pregnant women. The receiver operating characteristics plots revealed that serum aspartate aminotransferase level had area under the curve of 0.89 (95% CI: 0.84-0.95) and can distinguish preeclampsia patients from normotensive pregnant women at cut-off value of ≥58.5 U/l with 74.6% sensitivity, 87.3% specificity, and 80.9% diagnostic accuracy. Serum Creatinine level had area under the curve of 0.91 (95% CI: 0.86-0.96), which enabled to indicate preeclampsia at a cut-off value ≥0.90 mg/dl with 77.8% sensitivity and 85.7% specificity.
UNASSIGNED: An increased serum aminotransferases, total bilirubin, creatinine, and Urea levels in pregnant women could indicate the development of preeclampsia, and needs to be investigated. Among biochemical tests, serum Creatinine level was the best diagnostic marker of preeclampsia, followed by serum aspartate aminotransferase level.