化合物6-甲氧基赛林,来源于丁谷穗花椒,展示了各种治疗特性,包括血管舒张,抗伤害性,抗炎,和免疫调节作用,以及最近发现的平喘特性。本研究旨在评估其在Balb/c小鼠中的临床前药代动力学和肺部给药。该方法涉及通过吸入和静脉途径施用该化合物,然后用高效液相色谱和二极管阵列检测(HPLC-DAD)收集血样进行分析。结果表明线性良好,精度,准确度,和化合物在生物样品中的稳定性。药代动力学参数,如消除率,半衰期,间隙,分配量,曲线下的面积,并确定了两种给药途径的平均停留时间,显示类似的配置文件。肺浓度明显高于血浆浓度,表明显著的肺渗透。这些发现表明6-甲氧基赛林是新的抗哮喘药物的有希望的候选药物,其有利的药代动力学特征和高肺穿透因子支持。这项研究代表了6-甲氧基赛林在小鼠体内的药代动力学和肺部给药的首次探索,强调其进一步药物开发的潜力。
The compound 6-methoxyseselin, derived from Zanthoxylum tingoassuiba, demonstrates various therapeutic properties, including vasorelaxation, antinociceptive, anti-inflammatory, and immunomodulatory effects, along with recently discovered antiasthmatic properties. This study aimed to evaluate its preclinical pharmacokinetics and pulmonary delivery in Balb/c mice. The method involved administering the compound via inhalation and intravenous routes, followed by blood sample collection for analysis using high-performance liquid chromatography with diode array detection (HPLC-DAD). The results indicated good linearity, precision, accuracy, and stability of the compound in the biological samples. Pharmacokinetic parameters such as the rate of elimination, half-life, clearance, volume of distribution, area under the curve, and mean residence time were determined for both administration routes, showing similar profiles. The lung concentrations were notably higher than the plasma concentrations, indicating significant lung penetration. These findings suggest 6-methoxyseselin as a promising candidate for new anti-asthmatic drugs, supported by its favorable pharmacokinetic profiles and high lung penetration factors. This study represents the first exploration of the pharmacokinetics and pulmonary delivery of 6-methoxyseselin in mice, highlighting its potential for further drug development.