bio-mimetic

生物模拟物
  • 文章类型: Journal Article
    人体肌肉可以随着身体的发育而生长和改变其长度;因此,需要根据不断变化的需求调节其形态的人造肌肉。在本文中,我们报告了一种策略,通过热力学扭曲耦合将人造肌肉转变为具有不同形态的新肌肉,并说明其在驱动过程中的结构演变。肌肉长度可以在很大的温度范围内连续调节,和致动通过连续改变温度而发生。该策略适用于不同的驱动模式,包括拉伸伸长率,拉伸收缩和扭转旋转。这是通过扭曲插入纤维中以产生扭转应力来实现的。纤维退火导致螺旋分子链的部分热力学弛豫,用作内部束缚并抑制纤维扭曲释放,从而产生在加热下启动的自支撑人造肌肉。在足够高的温度下,螺旋分子链进一步松弛,产生不同长度的新肌肉。结构研究提供了对热力学-扭曲耦合的理解。这项工作为智能材料提供了一种新的设计策略。
    Human muscles can grow and change their length with body development; therefore, artificial muscles that modulate their morphology according to changing needs are needed. In this paper, we report a strategy to transform an artificial muscle into a new muscle with a different morphology by thermodynamic-twist coupling, and illustrate its structural evolution during actuation. The muscle length can be continuously modulated over a large temperature range, and actuation occurs by continuously changing the temperature. This strategy is applicable to different actuation modes, including tensile elongation, tensile contraction and torsional rotation. This is realized by twist insertion into a fibre to produce torsional stress. Fibre annealing causes partial thermodynamic relaxation of the spiral molecular chains, which serves as internal tethering and inhibits fibre twist release, thus producing a self-supporting artificial muscle that actuates under heating. At a sufficiently high temperature, further relaxation of the spiral molecular chains occurs, resulting in a new muscle with a different length. A structural study provides an understanding of the thermodynamic-twist coupling. This work provides a new design strategy for intelligent materials.
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  • 文章类型: Journal Article
    设计具有足够强度的水凝胶,显著的抗溶胀性,低摩擦系数,优异的生物相容性,骨整合潜力对于替换关节软骨至关重要。然而,将所有这些特性整合到一种材料中仍然具有挑战性。在这项工作中,一种由聚乙烯醇制备的Janus水凝胶,壳聚糖,和透明质酸钠,然后进行单侧浸渍原位沉淀矿化,形成一层杂化的羟基磷灰石(HAp),其中两个表面具有不同的组成和功能。由于透明质酸钠的负羧基,顶面的摩擦系数低至0.024。由于HAp矿化层,底侧有成骨潜力。由于物理连接的协同作用,水凝胶显示高达78MPa的抗压强度。此外,即使在37°C下在PBS溶液中浸泡7天后,它也表现出显著的抗溶胀性,强度保持率接近100%。不存在有毒化学物质保持了起始聚合物的优点,并导致优异的生物相容性(细胞活力≈100%),使其成为关节软骨的理想替代品。
    Designing hydrogels with adequate strength, remarkable swelling resistance, low friction coefficient, excellent biocompatibility, and osseointegration potential is essential for replacing articular cartilage. However, it remains challenging to integrate all these properties into one material. In this work, a Janus hydrogel was prepared from polyvinyl alcohol, chitosan, and sodium hyaluronate, followed by a one-sided dipping in situ precipitation mineralization to form a layer of hybridized hydroxyapatite (HAp), wherein the two surfaces had distinct compositions and functions. Because of the negative carboxyl groups from sodium hyaluronate, the top surface possessed a friction coefficient as low as 0.024. On account of the HAp mineralized layer, the bottom side had osteogenesis potential. Owing to the synergy of physical linkages, the hydrogel displayed compressive strength as high as 78 MPa. Furthermore, it demonstrated remarkable swelling resistance with strength retention near 100% even after soaking in PBS solution at 37 °C for 7 days. The absence of toxic chemicals maintained the merits of starting polymers and resulted in excellent biocompatibility (cell viability ≈ 100%), making it an ideal substitute for articular cartilage.
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  • 文章类型: Journal Article
    在这里,制备了一种简易的大微孔聚己内酯/鸭足胶原支架(PCL/DC),并对其进行了表征,以证实其在骨组织工程中的适用性。用于骨组织工程和骨缺损再生的仿生支架是重要元素。PCL具有良好的生物相容性和生物可降解性,是一种广泛应用于骨组织工程的生物材料。然而,PCL的高疏水性和低细胞附着位点特性导致支架设计中的微环境不足。胶原蛋白是一种广泛用于组织工程的天然生物材料,具有优异的生物相容性,机械性能,和细胞附着部分。在可以获得胶原蛋白的资源中,DC含有大量的I型胶原(COL1),是生物相容的,并且具有成本效益。在这项研究中,通过将DC与PCL以不同比例混合并应用非溶剂诱导相分离(NIPS)和热诱导相分离(TIPS)(N-TIPS)来制造支架,溶剂浇铸和颗粒浸出(SCPL),气体发泡法制备大微孔结构。通过形态分析对制备的支架进行了表征,生物活性试验,物理化学分析,和机械测试。体外研究通过生存力测试进行,形态学观察,和基因表达。结果表明,DC的掺入增强了支架的物理化学和机械性能。此外,根据生物活性测试中的DC含量,形成了大量的骨模拟磷灰石。体外研究表明,PCL/DC支架具有生物相容性,磷灰石和DC的存在为细胞增殖和分化形成了有利的微环境。总的来说,新型多孔PCL/DC支架可作为骨组织工程和再生的生物材料模型。
    Herein, a facile macro- and microporous polycaprolactone/duck\'s feet collagen scaffold (PCL/DC) was fabricated and characterized to confirm its applicability in bone tissue engineering. A biomimetic scaffold for bone tissue engineering and regeneration for bone defects is an important element. PCL is a widely applied biomaterial for bone tissue engineering due to its biocompatibility and biodegradability. However, the high hydrophobicity and low cell attachment site properties of PCL lead to an insufficient microenvironment in designing a scaffold. Collagen is a nature-derived biomaterial that is widely used in tissue engineering and has excellent biocompatibility, mechanical properties, and cell attachment moieties. Among the resources from which collagen can be obtained, DC contains a high amount of collagen type I (COL1), is biocompatible, and is cost-effective. In this study, the scaffolds were fabricated by blending DC with PCL in various ratios and applied non-solvent-induced phase separation (NIPS) and thermal-induced phase separation (TIPS) (N-TIPS), solvent casting and particulate leaching (SCPL), and gas foaming method to fabricate macro- and microporous structure. The characterization of the fabricated scaffolds was carried out by morphological analysis, bioactivity test, physicochemical analysis, and mechanical test. In vitro study was carried out by viability test, morphology observation, and gene expression. The results showed that the incorporation of DC enhances the physicochemical and mechanical properties of the scaffolds. Also, a large amount of bone mimetic apatite was formed according to the DC content in the bioactivity test. The in vitro study showed that the PCL/DC scaffold is biocompatible and the existence of apatite and DC formed a favorable microenvironment for cell proliferation and differentiation. Overall, the novel porous PCL/DC scaffold can be a promising biomaterial model for bone tissue engineering and regeneration.
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  • 文章类型: Journal Article
    Underwater acoustic (UWA) biomimicking communications have been developed for covert communications. For the UWA covert communications, it is difficult to achieve the bit error rate (BER) and the degree of mimic (DoM) performances at the same time. This paper proposes a biomimicking covert communication method to increase both BER and DoM (degree of mimic) performances based on the Time Frequency Shift Keying (TFSK). To increase DoM and BER performances, the orthogonality requirements of the time- and frequency-shifting units of the TFSK are theoretically derived, and the whistles are multiplied by the sequence with a large correlation. Two-step DoM assessments are also developed for the long-term whistle signals. Computer simulations and practical lake and ocean experiments demonstrate that the proposed method increases the DoM by 35% and attains a zero BER at -6 dB of Signal to Noise Ratio (SNR).
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  • 文章类型: Journal Article
    对于水声隐蔽通信,使用海豚口哨开发了仿生秘密通信。传统的仿生秘密通信方法传输的信号模式与真实的海豚哨声略有不同,这导致模仿程度低(DoM)。在本文中,我们提出了一种新颖的仿生通信方法,该方法以低误码率(BER)保留了大型DoM。对于变速器,所提出的方法利用真实海豚哨子的各种轮廓以及连续哨子之间的链接信息,并且所提出的接收器在链路信息的帮助下使用基于机器学习的哨子检测器。进行了计算机仿真和实际海洋实验,以证明该方法具有更好的BER性能。海洋实验表明,该方法的误码率为0.002,而传统的基于深度神经网络(DNN)的检测器的误码率为0.36。
    For underwater acoustic covert communications, biomimetic covert communications have been developed using dolphin whistles. The conventional biomimetic covert communication methods transmit slightly different signal patterns from real dolphin whistles, which results in a low degree of mimic (DoM). In this paper, we propose a novel biomimetic communication method that preserves the large DoM with a low bit error rate (BER). For the transmission, the proposed method utilizes the various contours of real dolphin whistles with the link information among consecutive whistles, and the proposed receiver uses machine learning based whistle detectors with the aid of the link information. Computer simulations and practical ocean experiments were executed to demonstrate the better BER performance of the proposed method. Ocean experiments demonstrate that the BER of the proposed method was 0.002, while the BER of the conventional Deep Neural Network (DNN) based detector showed 0.36.
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  • 文章类型: Journal Article
    在没有能量输入的情况下,固体表面上的液体单向传输将促进各种应用,例如在生物流体装置中,自润滑,和高分辨率打印。受天牛周体表面液体单向运输的启发,在这里,我们通过高分辨率立体光刻技术制造了一个模拟perstome的表面,并从通过X射线显微镜可视化的微观视图中展示了详细的单向运输机制。重要的是,提出并论证了一种溢流控制的液体单向输送机制。与在高能表面上对称扩散的完全润湿液体的规范预测不同,具有不同表面张力和粘度的液体可以自发地在一个优选的方向上传播,并在所有其他方向上传播。从这个强大的系统中获得的基本理解使我们能够定制先进的微计算机断层扫描和立体光刻制造,以模仿自然生物,并使用传统材料构建各种流体机器。
    Liquid uni-directional transport on solid surface without energy input would advance a variety of applications, such as in bio-fluidic devices, self-lubrication, and high-resolution printing. Inspired by the liquid uni-directional transportation on the peristome surface of Nepenthes alata, here, we fabricated a peristome-mimicking surface through high-resolution stereo-lithography and demonstrated the detailed uni-directional transportation mechanism from a micro-scaled view visualized through X-ray microscopy. Significantly, an overflow-controlled liquid uni-directional transportation mechanism is proposed and demonstrated. Unlike the canonical predictions for completely wetting liquids spreading symmetrically on a high-energy surface, liquids with varied surface tensions and viscosities can spontaneously propagate in a single preferred direction and pin in all others. The fundamental understanding gained from this robust system enabled us to tailor advanced micro-computerized tomography scanning and stereo-lithography fabrication to mimic natural creatures and construct a wide variety of fluidic machines out of traditional materials.
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  • 文章类型: Journal Article
    最近,在过去的十年中,机器人技术取得了重大进展,人工智能和其他认知相关领域,允许开发高度复杂的仿生机器人系统。此外,大量的机器人通过明确实现其面向生物的行为来设计和组装。为了增强这些设备的技能行为和足够的抓握能力,最近开发了一个新阶段的灵巧手,具有生物模仿导向和生物启发功能。撰写这篇综述论文的目的是对基于生物模拟的灵巧机器人多指人工手的开发提供详细的见解。截肢者应将“理想的”上肢假体视为其自然身体的一部分,并应复制截肢肢体的感觉运动能力。上肢截肢通常是身体突然受到创伤的结果,虽然它们也可以由恶性肿瘤引起,先天性缺陷和血管疾病。本文使用一个框架讨论了不同的生物模拟方法,该框架允许对基于生物和技术的手操纵行为进行共同描述。特别是,该评论着重于受启发的机器人系统的一些发展。总之,研究发现,在运动学方面的大量研究工作,动力学,正在采用建模和控制方法来改进目前的手技术,从而为截肢者的假肢提供更多功能。这将提高他们的生活质量,并有助于在不久的将来比较轻松地执行日常生活活动(ADL)任务。
    Recently, significant advances over the past decade have been made in robotics, artificial intelligence and other cognitive related fields, allowing development of highly sophisticated bio-mimetic robotics systems. In addition, enormous number of robots have been designed and assembled by explicitly realising their biological oriented behaviours. To enhance skill behaviours and adequate grasping abilities in these devices, a new phase of dexterous hands has been developed recently with bio-mimetically oriented and bio-inspired functionalities. The aim in writing this review paper is to present a detailed insight towards the development of the bio-mimetic based dexterous robotic multi-fingered artificial hand. An \"ideal\" upper limb prosthesis should be perceived as a part of their natural body by the amputee and should replicate sensory-motor capabilities of the amputated limb. Upper-limb amputations are most often the result of sudden trauma to the body, although they also can be caused by malignancy, congenital deficiencies and vascular diseases. This paper discusses the different bio-mimetic approaches using a framework that permits for a common description of biological and technical based hand manipulation behaviour. In particular, the review focuses on a number of developments in the inspired robotic systems. In conclusion, the study found that a huge amount of research efforts in terms of kinematics, dynamics, modelling and control methodologies are being put in to improve the present hand technology, thereby providing more functionality to the prosthetic limb of the amputee. This would improve their quality-of-life and help in performing activities of daily living (ADL) tasks with comparative ease in the near future.
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  • 文章类型: Journal Article
    在这里,我们描述了一个简单的,使用Anasplatyrhynchos的蛋壳的水性提取物生产稻形金纳米结构的绿色和无模板方法。合成的纳米粒子通过紫外可见,透射电子显微镜(TEM),选区电子衍射图(SAED)和FT-IR研究。合成的金纳米结构的UV-可见光谱显示在约540nm处的横向模式表面等离子体共振峰(SPR)和在880nm处的纵向模式。TEM和SAED图案证实了形态,合成的金纳米冰的尺寸和晶体结构。合成的金纳米片用于通过光降解去除有毒的曙红Y染料。观察到染料在1小时内完全降解,发现百分比效率为96.1%。
    Herein, we describe a simple, green and template free method for the production of rice shaped gold nanostructures using an aqueous extract of the egg shells of Anas platyrhynchos. The synthesized nanoparticles were characterized by UV-visible, transmission electron microscopy (TEM), selected area electron diffraction pattern (SAED) and FT-IR studies. The UV-visible spectrum of the synthesized gold nanostructures showed a transverse mode surface plasmon resonance peaks (SPR) at around 540nm and a longitudinal mode at 880nm. The TEM and SAED pattern confirmed the morphology, size and crystallographic structure of the synthesized gold nanorice. The synthesized gold nanorice was utilized for the removal of a toxic Eosin Y dye by photodegradation. It was observed that the dye was degraded completely within 1h and the percentage efficiency was found to be 96.1%.
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  • 文章类型: Journal Article
    虽然许多形式的游泳和飞行的尾流结构都有很好的特征,尚未分析自由游动的起伏鳍所产生的尾流。这些细长的鳍使鱼类能够获得增强的敏捷性,刀鱼的向后和垂直游泳能力,并且在更具机动性的水下航行器的设计中也有潜在的应用。我们使用粒子图像测速技术来测量尾流中的流体速度场,介绍了起伏的机器人鳍模型的流动结构。我们用高保真计算流体动力学来补充实验机器人的工作,模拟两种虚拟鱼的流体动力学,他们的鳍运动学和鳍加身体形态是根据自由游泳的刀鱼测量的,和我们机器人的虚拟渲染。我们的结果表明,随着波动波沿着翅片纵向传播,一系列相连的涡流管从翅片的长边缘脱落。与翅片成斜角的射流与连续的涡流管相关联,推动鱼前进。旋涡结构与尾翼摆动器的摆动尾鳍的链接旋涡环结构相似,尽管涡流环由于细长鳍的起伏运动学而变形。
    While wake structures of many forms of swimming and flying are well characterized, the wake generated by a freely swimming undulating fin has not yet been analyzed. These elongated fins allow fish to achieve enhanced agility exemplified by the forward, backward and vertical swimming capabilities of knifefish, and also have potential applications in the design of more maneuverable underwater vehicles. We present the flow structure of an undulating robotic fin model using particle image velocimetry to measure fluid velocity fields in the wake. We supplement the experimental robotic work with high-fidelity computational fluid dynamics, simulating the hydrodynamics of both a virtual fish, whose fin kinematics and fin plus body morphology are measured from a freely swimming knifefish, and a virtual rendering of our robot. Our results indicate that a series of linked vortex tubes is shed off the long edge of the fin as the undulatory wave travels lengthwise along the fin. A jet at an oblique angle to the fin is associated with the successive vortex tubes, propelling the fish forward. The vortex structure bears similarity to the linked vortex ring structure trailing the oscillating caudal fin of a carangiform swimmer, though the vortex rings are distorted because of the undulatory kinematics of the elongated fin.
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