背景:近年来,肿瘤相关细菌和肠道微生物群因其在癌症发展和治疗反应中的潜在作用而受到广泛关注。这篇综述旨在讨论胃肠道外的肿瘤内细菌的贡献,除了探索机制之外,功能,以及这些细菌在癌症治疗中的意义。
方法:我们回顾了当前关于肿瘤内细菌及其对肿瘤发生的影响的文献,programming,转移,耐药性,和抗肿瘤免疫调节。此外,我们研究了用于检测肿瘤内细菌的技术,处理低微生物量肿瘤样品时必须采取的预防措施,以及细菌操作治疗肿瘤的最新进展。
结果:研究表明,每种类型的癌症与其微生物组独特地相互作用,即使在低细菌丰度的非胃肠道肿瘤中也可以检测到细菌。细胞内细菌具有调节肿瘤细胞生物学行为的潜力,并有助于肿瘤发展的关键方面。此外,基于细菌的抗肿瘤疗法在癌症治疗中显示出有希望的结果。
结论:了解肿瘤内细菌和肿瘤细胞之间的复杂相互作用可能会导致更精确的癌症治疗策略的发展。需要对非胃肠道肿瘤相关细菌的进一步研究,以确定新的治疗方法,并扩大我们对微生物群在癌症生物学中的作用的认识。
Tumor-associated bacteria and gut microbiota have gained significant attention in recent years due to their potential role in cancer development and therapeutic response. This review aims to discuss the contributions of intratumor bacteria outside the gastrointestinal tract, in addition to exploring the mechanisms, functions, and implications of these bacteria in cancer therapy.
We reviewed current literature on intratumor bacteria and their impact on tumorigenesis, progression, metastasis, drug resistance, and anti-tumor immune modulation. Additionally, we examined techniques used to detect intratumor bacteria, precautions necessary when handling low microbial biomass tumor samples, and the recent progress in bacterial manipulation for tumor treatment.
Research indicates that each type of cancer uniquely interacts with its microbiome, and bacteria can be detected even in non-gastrointestinal tumors with low bacterial abundance. Intracellular bacteria have the potential to regulate tumor cells\' biological behavior and contribute to critical aspects of tumor development. Furthermore, bacterial-based anti-tumor therapies have shown promising results in cancer treatment.
Understanding the complex interactions between intratumor bacteria and tumor cells could lead to the development of more precise cancer treatment strategies. Further research into non-gastrointestinal tumor-associated bacteria is needed to identify new therapeutic approaches and expand our knowledge of the microbiota\'s role in cancer biology.