目的:这项研究的目的是研究与对照组相比,患有特发性喉麻痹(ILP)的拉布拉多寻回犬的血浆神经丝轻链(pNfL)浓度是否发生变化。次要目的是调查年龄之间的关系,高度,体重,和所研究人群的体重指数。
方法:123只狗:62只纯种拉布拉多猎犬患有ILP(ILP病例)和61只年龄匹配的健康中大型犬(对照)。
方法:狗,从2016年8月1日至2022年3月1日招募,根据体检组合分为病例或对照,神经系统检查,和历史。收集血浆,并测量pNfL浓度。在ILP病例和对照之间比较pNfL浓度。协变量包括年龄,高度,和重量被收集。在组内和组间分析pNfL和协变量之间的关系。在不同时间点可获得2份血浆样本的狗中,测量pNfL浓度以评估随时间的变化。
结果:在ILP病例和对照组之间没有发现pNfL浓度的显著差异(P=0.36)。对照组的pNfL浓度与体重和身高呈中度负相关;其他变量与ILP病例或对照组的pNfL浓度无关。pNfL浓度与拉布拉多寻回犬的ILP疾病状态或持续时间无关。
结论:与健康对照相比,没有证据表明pNfL水平因ILP疾病持续时间或进展而改变。当评估狗体内的pNfL浓度时,应该考虑体重和身高。
OBJECTIVE: The aim of this study was to investigate whether plasma neurofilament light chain (pNfL) concentration was altered in Labrador Retrievers with idiopathic laryngeal paralysis (ILP) compared to a control population. A secondary aim was to investigate relationships between age, height, weight, and body mass index in the populations studied.
METHODS: 123 dogs: 62 purebred Labrador Retrievers with ILP (ILP Cases) and 61 age-matched healthy medium- to large-breed dogs (Controls).
METHODS: Dogs, recruited from August 1, 2016, to March 1, 2022, were categorized as case or control based on a combination of physical exam, neurologic exam, and history. Blood plasma was collected, and pNfL concentration was measured. pNfL concentrations were compared between ILP Cases and Controls. Covariables including age, height, and weight were collected. Relationships between pNfL and covariables were analyzed within and between groups. In dogs where 2 plasma samples were available from differing time points, pNfL concentrations were measured to evaluate alterations over time.
RESULTS: No significant difference in pNfL concentration was found between ILP Cases and Control (P = .36). pNfL concentrations had moderate negative correlations with weight and height in the Control group; other variables did not correlate with pNfL concentrations in ILP Case or Control groups. pNfL concentrations do not correlate with ILP disease status or duration in Labrador Retrievers.
CONCLUSIONS: There is no evidence that pNfL levels are altered due to ILP disease duration or progression when compared with healthy controls. When evaluating pNfL concentrations in the dog, weight and height should be considered.