虽然端粒酶具有干预年龄相关疾病的潜力,端粒酶在大约90%的癌症中过度表达,在HIV病毒储库中,抗衰老端粒酶疗法中的注意事项。虽然多篇评论记录了端粒酶对端粒维持的规范功能,以及越来越多的评论揭示了端粒酶的新的非规范功能,目前还没有系统的综述集中于端粒酶逆转录酶蛋白(TERT)亚单位的一系列关联,将其作为难题的一部分,以组合特定TERT复合物如何独特地影响衰老和与年龄相关的疾病的图景。
使用国家生物技术信息中心发布的数据库对TERT复合物的书目数据进行了结构化搜索,该数据库可以广泛访问生物医学和基因组信息,以获得对TERT复合物的独特记录和引用概述,这些复合物可能会独特地影响衰老和与年龄相关的疾病。
TERT协会包括适当的折叠,细胞内TERT转运,新陈代谢,线粒体ROS(活性氧)调节,炎症,细胞分裂,细胞死亡,和基因表达,除了众所周知的端粒维护。而细胞周期抑制剂的增加促进衰老,在癌症中,细胞周期检查点调节剂被伏击有利于细胞增殖,而胞质TERT保护氧化应激中的细胞周期抑制剂。癌基因cMyc调节TERT过表达的基因表达,和减少细胞周期抑制剂-癌症促进的完美风暴。TERT与癌基因RMRPRNA结合,TERT-RMRP功能可以调节癌基因RNA的水平,TBN复合物中的TERT可以调节异染色质。端粒酶的益处和新功能在神经病学和心脏病学研究中打开了新的抗衰老希望。GV1001,TERT的16个氨基酸的肽,与热休克蛋白(HSP)相关,绕过细胞膜,具有显著的抗病潜力。
TERT“Associates”是下调的抗癌目标,而是在抗衰老治疗中的上调.概述揭示了影响跨NIHGeroscienceInitiative确定的所有七个衰老支柱的独特TERT关联,这些影响衰老并敦促研究适当的靶向端粒酶补充剂/刺激,并纳入国家老龄化干预测试计划研究所。使用可用的“智能药物”的偏好,只针对癌症,TERT相关功能的多重性暗示了不脱靶的抗衰老端粒酶。
Although telomerase has potential for age-related disease intervention, the overexpression of telomerase in about 90% of cancers, and in HIV virus reservoirs, cautions against se in anti-aging telomerase therapeutics. While multiple reviews document the canonical function of telomerase for maintenance of telomeres, as well as an increasing numbers of reviews that reveal new non-canonical functions of telomerase, there was no systematic review that focuses on the array of
associates of the subunit of Telomerase Reverse transcriptase protein (TERT) as pieces of the puzzle to assemble a picture of the how specific TERT complexes uniquely impact aging and age-related diseases and more can be expected.
A structured search of bibliographic data on TERT complexes was undertaken using databases from the National Center for Biotechnology Information Pubmed with extensive access to biomedical and genomic information in order to obtain a unique documented and cited overview of TERT complexes that may uniquely impact aging and age-related diseases.
The TERT associations include proper folding, intracellular TERT transport, metabolism, mitochondrial ROS (Reactive Oxygen Species) regulation, inflammation, cell division, cell death, and gene expression, in addition to the well-known telomere maintenance. While increase of cell cycle inhibitors promote aging, in cancer, the cell cycle check-point regulators are ambushed in favor of cell proliferation, while cytoplasmic TERT protects a cell cycle inhibitor in oxidative stress. The oncogene cMyc regulates gene expression for overexpression of TERT, and reduction of cell cycle inhibitors-the perfect storm for cancer promotion. TERT binds with the oncogene RMRP RNA, and TERT-RMRP function can regulate levels of that oncogene RNA, and TERT in a TBN complex can regulate heterochromatin. Telomerase benefit and novel function in neurology and cardiology studies open new anti- aging hope. GV1001, a 16 amino acid peptide of TERT that
associates with Heat Shock Proteins (HSP\'s), bypasses the cell membrane with remarkable anti disease potential.
TERT \"
associates\" are anti-cancer targets for downregulation, but upregulation in antiaging therapy. The overview revealed that unique TERT associations that impact all seven pillars of aging identified by the Trans-NIH Geroscience Initiative that influence aging and urge research for appropriate targeted telomerase supplements/ stimulation, and inclusion in National Institute on Aging Intervention Testing Program. The preference for use of available \"smart drugs\", targeted to only cancer, not off-target anti- aging telomerase is implied by the multiplicity of TERT
associates functions.