未经证实:右心室易发生运动引起的病理性改变。这可能导致ECG的变化。我们的目的是确定运动诱发(ExI)心律失常性心肌病(ACM)的心电图表型。
未经评估:对静息状态下的心电图进行回顾性分析,在四组个体中进行了高峰运动和1分钟的恢复:具有遗传确认的心律失常性心肌病(Gen-ACM;n=16),(基因阴性)ExI-ACM(n=15),控制耐力运动员(结束;n=16)和久坐的个体(Sed;n=16)。室性心律失常(VA)的发生和,在每个阶段,QRS持续时间,终端激活延迟(TAD),右前兆QRS持续时间之和(V1-V3)与左前兆QRS持续时间之比(V4-V6;R/L持续时间比),评估是否存在超过V2导联的完全RBBB和T波倒置(TWI)。
未经评估:在休息时,完全RBBB仅在Gen-ACM(6%)和ExI-ACM(13%)中发现。没有发现ε波。超过V2的TWI独特地存在于Gen-ACM(73%)和ExI-ACM(38%;p<0.001)中。VA存在于Gen-ACM(88%);ExI-ACM(80%),结束(25%)和Sed(19%;p<0.001)。R/L持续时间>1.2和TAD≥55ms的存在在四组中没有显着差异(分别为p=0.584和p=0.218)。在高峰运动时,最引人注目的发现是ACM患者的R/L持续时间比率显着降低,这是侧心前QRS波延长的结果。
未经证实:ExI-ACM与Gen-ACM共享重要的ECG特征,提示一个相似的潜在发病机制,无论是否存在桥粒突变。
UNASSIGNED: The right ventricle can be susceptible to pathologic alterations with exercise. This can cause changes to the ECG. Our aim was to identify the electrocardiographic phenotype of exercise induced (ExI) arrhythmogenic cardiomyopathy (ACM).
UNASSIGNED: A retrospective analysis of ECGs at rest, peak exercise and 1 min of recovery in four groups of individuals was performed: Arrhythmogenic Cardiomyopathy with genetic confirmation (Gen-ACM; n = 16), (genetically negative) ExI-ACM (n = 15), control endurance athletes (End; n = 16) and sedentary individuals (Sed; n = 16). The occurrence of ventricular arrhythmias (VA) and, at each stage, QRS duration, Terminal Activation Delay (TAD), the ratio of the sum of the QRS durations in the right precordials (V1-V3) over that in the left precordials (V4-V6; R/L duration ratio), the presence of complete RBBB and T-wave inversion (TWI) beyond lead V2 were evaluated.
UNASSIGNED: At rest, complete RBBB was exclusively found in Gen-ACM (6%) and ExI-ACM (13%). No epsilon waves were identified. TWI beyond V2 was uniquely present in Gen-ACM (73%) and ExI-ACM (38%; p < 0.001). VA was present in Gen-ACM (88%); ExI-ACM (80%), End (25%) and Sed (19%; p < 0.001). The presence of R/L duration ratio of >1.2 and TAD ≥ 55 ms were not significantly different over the four groups (p = 0.584 and p = 0.218, respectively). At peak exercise the most striking finding was a significant decrease of the R/L duration ratio in individuals with ACM, which was the result of lateral precordial QRS prolongation.
UNASSIGNED: ExI-ACM shares important ECG-features with Gen-ACM, suggesting a similar underlying pathogenesis regardless of the presence or absence of desmosomal mutations.