未经证实:高胆固醇血症是一种常见的心血管危险因素。本研究的目的是调查CELSR2(rs629301),APOB100(rs1367117),ABCG5/8(rs6544713),LDLR(rs6511720),和APOE(rs429358,rs7412)多态性,和他们的遗传风险评分与泰国受试者的血脂。
未经评估:共有459名研究对象(184名男性,和275名女性)被登记。血压,血脂,并测量空腹血糖。CELSR2(rs629301),APOB100(rs1367117),ABCG5/8(rs6544713),使用PCR-HRM分析LDLR(rs6511720)多态性。使用PCR-RFLP分析APOE(rs429358,rs7412)多态性。
UNASSIGNED:APOB100AA基因型的总胆固醇(TC)水平明显高于GG,或总受试者中的AA+AG基因型。此外,与APOE2携带者相比,APOE4携带者的TC和低密度脂蛋白胆固醇(LDL-C)浓度明显更高,男性,和女性。与雌性中的APOE3携带者相比,在APOE4携带者中观察到明显更高的TC浓度。此外,TC的浓度,和LDL-C随着APOB100的遗传风险评分和APOE多态性在总受试者中显著增加,和女性。CELSR2(rs629301)之间没有关联,ABCG5/8(rs6544713),和LDLR(rs6511720)多态性和血脂。
未经批准:APOB100(rs1367117),和APOE(rs429358,rs7412),但不是CELSR2(rs629301),ABCG5/8(rs6544713),LDLR(rs6511720)多态性与血脂相关。APOB100的累积风险等位基因(rs1367117),APOE(rs429358,rs7412)多态性可以增强TC浓度的升高,和LDL-C,它们可用于预测泰国受试者中高胆固醇血症的严重程度。
UNASSIGNED: Hypercholesterolemia is a common cardiovascular risk factor. The aim of this study was to investigate the association of CELSR2 (rs629301),
APOB100 (rs1367117), ABCG5/8 (rs6544713), LDLR (rs6511720), and APOE (rs429358, rs7412) polymorphisms, and their genetic risk scores with lipids among Thai subjects.
UNASSIGNED: A total of 459 study subjects (184 males, and 275 females) were enrolled. Blood pressure, serum lipids, and fasting blood sugar were measured. CELSR2 (rs629301),
APOB100 (rs1367117), ABCG5/8 (rs6544713), and LDLR (rs6511720) polymorphisms were analyzed using PCR-HRM. APOE (rs429358, rs7412) polymorphism was analyzed using PCR-RFLP.
UNASSIGNED: Total cholesterol (TC) levels were significantly higher in
APOB100 AA genotype compared with GG, or AA + AG genotypes in total subjects. In addition, significantly higher concentrations of TC and low density lipoprotein cholesterol (LDL-C) were observed in APOE4 carriers compared to APOE2 carriers in total subjects, males, and females. The significantly higher concentrations of TC were observed in APOE4 carriers compared to APOE3 carriers in females. Moreover, the concentrations of TC, and LDL-C were significantly increased with genetic risk scores of APOB100, and APOE polymorphisms in total subjects, and females. There was no association between CELSR2 (rs629301), ABCG5/8 (rs6544713), and LDLR (rs6511720) polymorphisms and serum lipids.
UNASSIGNED: APOB100 (rs1367117), and APOE (rs429358, rs7412) but not CELSR2 (rs629301), ABCG5/8 (rs6544713), and LDLR (rs6511720) polymorphisms were associated with serum lipids. The cumulative risk alleles of
APOB100 (rs1367117), and APOE (rs429358, rs7412) polymorphisms could enhance the elevated concentrations of TC, and LDL-C, and they may be used to predict severity of hypercholesterolemia among Thai subjects.