■本研究致力于研究阻塞性睡眠呼吸暂停(OSA)与认知功能之间的相互关系,伴随着抑郁和焦虑的表现。同时,对影响认知功能的因素进行了分析。
■102名患者的队列,在滨湖医院接受多导睡眠监测(PSG)的人,安徽医科大学,2022年1月至2023年6月,纳入研究。采用PSG的调查结果,这些人被分为两个不同的类别:分组包括那些可以忽略或轻度OSA,另一个包括患有中度至重度OSA的个体。利用蒙特利尔认知评估(MoCA-北京),Stroop颜色和单词测试(SCWT),数字跨度测试(DST),抑郁自评量表(SDS),和焦虑自评量表(SAS),记录并分析各项评估的得分.此外,还审查了这些群体之间的差异和关联。
■表现为中度至重度OSA的组表现出颈围等参数的测量值显著升高,BMI,SCWT-A的完成时间,B,C,睡眠效率低下指数(SIE),SAS,SDS,与无或轻度OSA组相比。此外,中重度OSA组表现为视觉空间和执行功能领域的MoCA评分明显下降,记忆,语言,抽象,延迟召回,定位,MoCA总分,最低氧饱和度(LSaO2),平均血氧饱和度,数字跨度向后测试(DST-b),和数字跨前测试(DST-f),与非轻度OSA组形成对比。这些组间差异表现出统计学意义(p<0.05)。MoCA总分描绘了与年龄的负相关,呼吸暂停-呼吸不足指数(AHI),BMI,SIE,SAS,SDS,CT90%,AHT90%,和低氧性呼吸暂停持续时间(HAD)(范围从-0.380到-0.481,p<0.05)。相反,它与DST-f呈正相关,DST-b,LSaO2和平均氧饱和度(范围从0.414到0.744,p<0.05)。颈围,AHI,SAS与MoCA评分自主相关(OR=1.401,1.028,1.070,p<0.05),而AHI与SDS和SAS评分呈独立相关性(OR=1.001,p=0.003)。
■患有中度至重度OSA的患者经常表现出认知障碍和伴随的情绪困境,包括抑郁和焦虑。这些表现与AHI有着密切的联系,LSaO2和平均血氧饱和度。值得注意的是,焦虑,当与OSA结合时,作为影响认知障碍的自主影响因素而出现。
UNASSIGNED: The present study endeavored to investigate the interconnection between obstructive sleep apnea (OSA) and cognitive function, alongside the manifestations of depression and anxiety. Simultaneously, an analysis was conducted to discern the factors exerting influence upon cognitive function.
UNASSIGNED: A cohort of 102 patients, who had undergone polysomnography (PSG) at Binhu Hospital, Anhui Medical University, between January 2022 and June 2023, was encompassed in the study. Employing the PSG findings, these individuals were classified into two distinct categories: the grouping consisted of those with either negligible or mild OSA, and the other comprised individuals with moderate to severe OSA. Utilizing the Montreal Cognitive Assessment (MoCA-Beijing), Stroop Color and Word Test (SCWT), Digit Span Test (DST), Self-rating Depression Scale (SDS), and Self-rating Anxiety Scale (SAS), scores were recorded and analysed for each of the respective assessments. Additionally, discrepancies and associations between these groups were also scrutinized.
UNASSIGNED: The group exhibiting moderate to severe OSA demonstrated significantly elevated measurements in parameters such as neck circumference, BMI, completion times for SCWT-A, B, C, Sleep Inefficiency Index (SIE), SAS, and SDS, in comparison to the No or Mild OSA group. Furthermore, the moderate-severe OSA group manifested notably diminished MoCA scores in areas of visual-spatial and executive function, memory, language, abstraction, delayed recall, orientation, total MoCA score, lowest oxygen saturation (LSaO2), average oxygen saturation, Digit Span Test-backward(DST-b), and Digit Span Test-forward(DST-f), as contrasted with the no-mild OSA group. These inter-group disparities exhibited statistical significance (p < 0.05). The MoCA total score portrayed inverse correlations with age, Apnea-Hypopnea Index (AHI), BMI, SIE, SAS, SDS, CT90%, AHT90%, and Hypoxic Apnea Duration (HAD) (ranging from -0.380 to -0.481, p < 0.05). Conversely, it displayed positive correlations with DST-f, DST-b, LSaO2, and average oxygen saturation (ranging from 0.414 to 0.744, p < 0.05). Neck circumference, AHI, and SAS were autonomously linked to MoCA scores (OR = 1.401, 1.028, 1.070, p < 0.05), while AHI exhibited an independent correlation with SDS and SAS scores (OR = 1.001, p = 0.003).
UNASSIGNED: Patients grappling with moderate to severe OSA frequently reveal cognitive impairment and concomitant emotional predicaments encompassing depression and anxiety. These manifestations share an intimate association with AHI, LSaO2, and average oxygen saturation. Notably, anxiety, when coupled with OSA, emerges as an autonomous influential element impinging upon cognitive impairment.