目的:阻塞性睡眠呼吸暂停综合征(OSAS)是一种常见的睡眠障碍,由上呼吸道气流减少或停止引起。Irisin,视黄醇结合蛋白-4(RBP-4),脂联素是人体代谢过程中的三个重要因子。这项研究的目的是调查血浆irisin,RBP-4和脂联素水平与OSAS的严重程度相关。
方法:根据纳入和排除标准,125名OSAS患者和46名健康者,性别匹配的对照纳入本研究.根据呼吸暂停低通气指数(AHI)将患者分为14例(5
30)。等离子体irisin,测量并比较两组之间的RBP-4和脂联素水平。
结果:重度OSAS患者的RBP-4水平高于其他组,与其他组相比,重度OSAS患者的irisin水平显著降低.Irisin与RBP-4呈负相关(r=-0.421;p<0.001),和irisin和AHI(r=-0.834;p<0.001),irisin和脂联素之间呈正相关(r=0.240;p=0.002)。RBP-4与脂联素呈负相关(r=-0.507;p<0.001),RBP-4与AHI呈正相关(r=0.473;p<0.001)。作为OSAS的预测指标,脂联素特异性最高(84.8%),RBP-4敏感性最高(92.0%)。
结论:循环脂联素,irisin,RBP-4可能是OSAS患者除糖尿病等危险因素外的新生物标志物,肥胖,和高血压。当多导睡眠图不可用时,这些参数和临床数据可用于诊断疾病。因此,AHI评分大于30分的患者应密切监测代谢异常.
Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that is caused by the reduction or cessation of airflow in the upper airway. Irisin, retinol-binding protein-4 (RBP-4), and adiponectin are the three significant factors in the metabolic process of the human body. The objective of this study was to investigate whether plasma irisin, RBP-4, and adiponectin levels are associated with the severity of OSAS.
According to inclusion and exclusion criteria, 125 patients with OSAS and 46 healthy, gender-matched controls were included in this study. The patients were classified according to the apnea hypopnea index (AHI) as 14 mild cases (5 < AHI < 15), 23 moderate OSAS cases (15 < AHI < 30), and 88 severe OSAS cases (AHI > 30). The plasma irisin, RBP-4, and adiponectin levels were measured and compared between groups.
RBP-4 levels were higher in severe OSAS compared to other groups, and irisin levels were significantly lower in severe OSAS compared to other groups. There was a negative correlation between irisin and RBP-4 (r = -0.421; p < 0.001), and irisin and AHI (r = -0.834; p < 0.001), and a positive correlation between irisin and adiponectin (r = 0.240; p = 0.002). There was a negative correlation between RBP-4 and adiponectin (r = -0.507; p < 0.001) and a positive correlation between RBP-4 and AHI (r = 0.473; p < 0.001). As a predictor of OSAS, adiponectin showed the highest specificity (84.8%) and RBP-4 the highest sensitivity (92.0%).
Circulating adiponectin, irisin, and RBP-4 may be new biomarkers in OSAS patients in addition to risk factors such as diabetes, obesity, and hypertension. When polysomnography is not available, these parameters and clinical data can be used to diagnose the disease. As a result, patients with an AHI score greater than thirty should be closely monitored for metabolic abnormalities.