背景主动脉根扩张是法洛四联症(TOF)修复患者中越来越多的特征。然而,很少研究未修复TOF中主动脉根部和升主动脉的扩张。这项研究旨在确认主动脉扩张是否是未修复的TOF的共同特征,并调查归因于主动脉扩张的因素。方法回顾性研究超声心动图诊断为TOF的患者接受计算机断层扫描血管造影。主动脉瓣环(Ao1)的直径和z值,主动脉窦管交界处(Ao2),升主动脉(Ao3),测量远端横主动脉弓(Ao4)。术前体表面积(BSA);血红蛋白(Hb),血细胞比容(HCT),动脉血氧饱和度(SaO2),记录血小板(PLT)计数。结果共纳入101例年龄为6.8±9.5岁的TOF患者,其平均BSA(m2),Hb(g/L),HCT,SaO2(%),PLT(109/L)分别为0.7±0.4、162.1±3.8、0.5±0.1、85.1±9.3和238.1±101.1。Ao1、Ao2、Ao3和Ao4的平均z评分分别为10.3±3.5、4.7±2.9、4.0±2.7和4.1±2.4。年龄和BSA与Ao1和Ao2的z评分呈正相关。术前Hb和HCT与Ao1、Ao2、Ao3、Ao4的z评分呈正相关。术前SaO2和PLT与Ao1、Ao2、Ao3和Ao4的z评分呈负相关。结论主动脉扩张在未修复的TOF患者中较为常见。主动脉不同程度的扩张与年龄相关,BSA,术前Hb,HCT,SaO2和PLT。
Background Aortic root dilation is an increasingly recognized feature in repaired tetralogy of Fallot (TOF) patients. However, the dilation at the aortic root and ascending aorta in unrepaired TOF is rarely studied. This study aims to confirm whether aortic dilation is a common feature in unrepaired TOF and investigate the factors attributed to aortic dilation. Methodology Patients with an echocardiographic diagnosis of TOF undergoing computed tomography angiography were retrospectively studied. Diameters and z scores of aortic annular (Ao1), aortic sinotubular junction (Ao2), ascending aorta (Ao3), and distal transverse aortic arch (Ao4) were measured. Preoperative body surface area (BSA), hemoglobin (Hb), hematocrit (HCT), arterial oxygen saturation (SaO2), and platelet (PLT) count were recorded. Results A total of 101 TOF patients aged 6.8 ± 9.5 years were included in this study, whose mean BSA (m2), Hb (g/L), HCT, SaO2 (%), and PLT (109/L) were 0.7 ± 0.4, 162.1 ± 3.8, 0.5 ± 0.1, 85.1 ± 9.3, and 238.1 ± 101.1, respectively. The mean z score of Ao1, Ao2, Ao3, and Ao4 were 10.3 ± 3.5, 4.7 ± 2.9, 4.0 ± 2.7, and 4.1 ± 2.4, respectively. Age and BSA were positively correlated with the z scores of Ao1 and Ao2. Preoperative Hb and HCT were positively correlated with the z scores of Ao1, Ao2, Ao3, and Ao4. Preoperative SaO2 and PLT were negatively correlated with the z scores of Ao1, Ao2, Ao3, and Ao4. Conclusions Aortic dilation is common in unrepaired TOF patients. The dilation of different levels of the aorta was correlated with age, BSA, preoperative Hb, HCT, SaO2, and PLT.