目的:任何形式的癫痫发作都会给患者的身体带来广泛的问题,心理,和社会健康。本研究旨在探讨胡椒碱的抗癫痫和抗癫痫作用及其机制。
方法:在本系统综述研究中,这是根据PRISMA2020的原则进行的,最初的搜索是在2023年11月2日使用EndNote软件进行的。各种数据库,如PubMed,科克伦图书馆,WebofScience,Embase,和Scopus使用特定的关键字进行搜索。筛选文章后,根据研究目标设计了一个表格,并在表格中输入了与所包含文章相关的信息,并对研究进行了综述。
结果:胡椒碱通过影响大脑的抗氧化剂显示其抗癫痫活性,抗炎,和抗凋亡活性。它也是,通过调节脑源性神经营养因子(BDNF)和γ-氨基丁酸(GABA)的活性,可以控制癫痫发作。此外,胡椒碱可以通过提高大脑中的5-HT水平来帮助治疗癫痫发作和癫痫,调节星形胶质细胞和小胶质细胞功能,对Ca2+和NA+通道的调节作用,提高抗癫痫药物的生物利用度,影响蛋白质和基因表达。
结论:体内和体外研究显示了治疗癫痫的有益效果。尽管临床研究也显示了类似的结果,这些需要增加,需要在这一领域设计更多的临床研究。
OBJECTIVE: Seizures due to epilepsy in any form cause a wide range of problems in a patient\'s physical, psychological, and social health. This study aimed to investigate piperine\'s anti-seizure and
antiepileptic effects and mechanisms.
METHODS: In this systematic review study, which was conducted according to the principles of PRISMA 2020, the initial search was conducted on November 2, 2023, using EndNote software. Various databases such as PubMed, Cochrane Library, Web of Science, Embase, and Scopus were searched using specific keywords. After screening the articles, a form was designed according to the objectives of the study, and the information related to the included articles was entered in the form, and the studies were reviewed.
RESULTS: Piperine showed its
antiepileptic activity by affecting the brain\'s antioxidant, anti-inflammatory, and anti-apoptotic activity. It also, by modulating brain-derived neurotrophic factor (BDNF) and gamma-aminobutyric acid (GABA)ergic activity, can control seizures. In addition, piperine can help treat seizures and epilepsy by elevating 5-HT levels in the brain, modulating astrocyte and microglia function, modulatory effects on Ca2+ and NA+ channels, increasing
antiepileptic drugs bioavailability and influencing protein and gene expression.
CONCLUSIONS: In vivo and in vitro studies showed beneficial effects on treating epilepsy. Although clinical studies also showed similar results, these needed to be increased, and more clinical studies needed to be designed in this field.