背景:TrametesRobiniophilaMurr,俗称淮儿,在中国的民族药理学研究中已被广泛记录。淮儿在中国有着1000多年的临床使用历史。传统的临床应用记录表明,淮儿广泛用于治疗各种癌症并增强肿瘤患者的自身免疫力。
目的:本研究对传统用途进行了全面回顾,植物化学成分,药理活性,抗肿瘤机制,以及淮尔的潜在应用,从而为进一步开发和利用这种天然产物提供有价值的见解。
方法:本研究使用关键词“TrametesRobiniophilaMurr”和“Huaier”从各种数据库中检索有关Huaier的信息,包括PubMed,WebofScience,Springer,科学直接,ACS,威利,CNKI,百度学者,谷歌学者,和古老的本草。
结果:TrametesRobiniophilaMurr(怀尔),中药,在各种肿瘤的临床治疗中表现出显著的疗效。淮尔的主要生物活性成分由真菌衍生的化合物组成,包括多糖,蛋白质,酮,生物碱,和矿物。研究结果表明,淮儿能有效抑制癌细胞增殖,是一种可靠的辅助治疗药物,诱导癌细胞凋亡,抑制肿瘤转移,调节肿瘤干细胞和免疫功能。因此,当与常规抗癌疗法结合使用时,它具有有效的抗肿瘤作用。
结论:对传统用途的分析,植物化学成分,和药理活性表明,淮儿作为药用植物具有多种药理作用,具有巨大的潜力。由于其众多优势,怀尔在肿瘤预防和治疗领域有着巨大的应用前景,提高癌症患者的生存时间和生活质量。
BACKGROUND: Trametes Robiniophila Murr, commonly known as Huaier, has been extensively documented in ethnopharmacology research in China. Huaier has a long history of clinical usage spanning over 1000 years in China. Traditional clinical application records demonstrate the wide utilization of Huaier for treating various cancers and enhancing the autoimmunity of tumor patients.
OBJECTIVE: The present study provides a comprehensive review of the traditional uses, phytochemical constituents, pharmacological activities, anti-tumor mechanism, and potential applications of Huaier, thereby offering valuable insights for the further development and utilization of this natural product.
METHODS: This study employed the keywords \"Trametes Robiniophila Murr\" and \"Huaier\" to retrieve relevant information on Huaier from various databases, including PubMed, Web of Science, Springer, Science Direct, ACS, Wiley, CNKI, Baidu Scholar, Google Scholar, and ancient materia medica.
RESULTS: Trametes Robiniophila Murr (Huaier), a traditional Chinese medicine, has demonstrated significant efficacy in the clinical treatment of various tumors. The primary bioactive constituents of Huaier consist of fungal-derived compounds, including polysaccharides, proteins, ketones, alkaloids, and minerals. The research findings demonstrate that Huaier serves as a reliable adjunctive therapeutic agent by effectively inhibiting cancer cell proliferation, inducing apoptosis in cancer cells, suppressing tumor metastasis, regulating tumor stem cells and immune function. Therefore, it exerts a potent anti-tumor effect when used in conjunction with conventional anti-cancer therapies.
CONCLUSIONS: The analysis of traditional uses, phytochemical composition, and pharmacological activity reveals that Huaier exhibits significant potential as a medicinal plant with diverse pharmacological effects. Owing to its numerous advantages, Huaier holds immense promise for application in the domains of tumor prevention and treatment, enhancing both survival time and quality of life among cancer patients.