目前,抗生素耐药性病原体的治疗成本高达数百亿美元。特别感兴趣的是使用抗菌涂料减少或解决这个问题,尤其是在医院或其他医疗机构。细菌可以从医务人员或被污染的表面转移到患者。在本文中,我们将注意力集中在两种掺杂有碳聚合点(CPD)和富勒烯C60的光动力聚氨酯复合膜的抗菌和抗生物结垢活性上。详细的原子力,静电力和粘弹性显微镜显示拓扑,所用填料和复合材料的纳米电学和纳米力学性能。建立了纳米碳填料的电子结构与复合材料的抗菌和抗生物污染活性之间的关系。对两种复合膜进行了活性氧(ROS)生成的彻底光谱分析,发现它们都是针对医院细菌的有效抗菌剂(肺炎克雷伯菌,变形杆菌,Salmonelaenterica,粪肠球菌,表皮肠球菌和铜绿假单胞菌)。复合膜的抗生物污染测试表明,CPD/PU复合膜几乎完全根除了铜绿假单胞菌和金黄色葡萄球菌的生物膜以及约50%的大肠杆菌生物膜。
The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and
antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60. Detailed atomic force, electrostatic force and viscoelastic microscopy revealed topology, nanoelectrical and nanomechanical properties of used fillers and composites. A relationship between the electronic structure of the nanocarbon fillers and the antibacterial and
antibiofouling activities of the composites was established. Thorough spectroscopic analysis of reactive oxygen species (ROS) generation was conducted for both composite films, and it was found that both of them were potent antibacterial agents against nosocomial bacteria (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, Enterococcus epidermis and Pseudomonas aeruginosa).
Antibiofouling testing of composite films indicated that the CPDs/PU composite films eradicated almost completely the biofilms of Pseudomonas aeruginosa and Staphylococcus aureus and about 50% of Escherichia coli biofilms.