对常规抗生素耐药性的日益关注强调了开发创新抗微生物剂的紧迫性。最近,金属有机框架(MOFs)由于其多方面的抗菌属性,在抗菌研究领域获得了显著的关注,包括持续释放内在或外源性抗菌成分,化学动力学催化产生活性氧(ROS),和光生ROS的形成。这篇全面的综述全面概述了MOF基材料生产中采用的合成方法,深入阐明其潜在的抗菌机制。重点在于阐明各种抗菌方式的研究进展,包含固有组分释放系统,外来组件释放系统,自动催化系统,和能量转换系统。此外,基于MOF的抗菌材料在解决伤口感染方面的进展,骨髓炎,牙周炎被精心阐明,总结了基于MOF的材料的抗微生物应用领域固有的挑战和潜在机遇。重要性声明:对常规抗生素耐药性的日益关注强调了对替代抗菌解决方案的需求。金属有机框架(MOFs)由于其不同的属性,如持续的抗菌成分释放,在抗菌研究中获得了重要的关注。催化产生活性氧(ROS),和光生ROS。本文综述了MOF的合成及其抗菌机制。它探讨了内在和外来组件释放的进步,自动催化,和能量转换系统。本文还讨论了基于MOF的材料在解决伤口感染方面的进展,骨髓炎,和牙周炎,以及现有的挑战和机遇。鉴于缺乏相关评论,我们的发现为未来MOF在抗菌研究中的应用提供了希望,使它与你的杂志的读者群相关。
The escalating concern over conventional antibiotic resistance has emphasized the urgency in developing innovative antimicrobial agents. In recent times, metal-organic frameworks (MOFs) have garnered significant attention within the realm of antimicrobial research due to their multifaceted antimicrobial attributes, including the sustained release of intrinsic or exogenous antimicrobial components, chemodynamically catalyzed generation of reactive oxygen species (ROS), and formation of photogenerated ROS. This comprehensive review provides a thorough overview of the synthetic approaches employed in the production of MOF-based materials, elucidating their underlying antimicrobial mechanisms in depth. The focal point lies in elucidating the research advancements across various antimicrobial modalities, encompassing intrinsic component release system, extraneous component release system, auto-catalytical system, and energy conversion system. Additionally, the progress of MOF-based antimicrobial materials in addressing wound infections, osteomyelitis, and periodontitis is meticulously elucidated, culminating in a summary of the challenges and potential opportunities inherent within the realm of antimicrobial applications for MOF-based materials. STATEMENT OF SIGNIFICANCE: Growing concerns about conventional antibiotic resistance emphasized the need for alternative antimicrobial solutions. Metal-organic frameworks (MOFs) have gained significant attention in antimicrobial research due to their diverse attributes like sustained antimicrobial components release, catalytic generation of reactive oxygen species (ROS), and photogenerated ROS. This review covers MOF synthesis and their antimicrobial mechanisms. It explores advancements in intrinsic and extraneous component release, auto-catalysis, and energy conversion systems. The paper also discusses MOF-based materials\' progress in addressing wound infections, osteomyelitis, and periodontitis, along with existing challenges and opportunities. Given the lack of related reviews, our findings hold promise for future MOF applications in antibacterial research, making it relevant to your journal\'s readership.