背景:消化性溃疡是一种由胃或消化道产生过多的酸引起的开放性溃疡,对粘膜层造成损害.:传统上以抗炎而闻名,抗氧化剂,抗菌活性,等。目的:基于其专门用于抗溃疡活性的功效的科学证据是有限的,因此,该研究旨在评估TG对阿司匹林诱导的消化性溃疡的保护作用。
方法:进行植物化学筛选,然后评估TG对阿司匹林诱导的大鼠毒性的保护作用。进行网络生物学和多药理学研究以确定与溃疡病理生理学有关的可能的分子靶标。
结果:研究表明,高剂量(500mg/kgb.w.)的TG提取物通过调节游离酸度胃蛋白酶的产生,对阿司匹林引起的溃疡具有明显的保护作用。通过调节抗氧化状态(SOD,GSH,CAT,etc).形态学研究显示,具有正常粘膜结构的胃粘膜层的损伤较小,药物治疗组未发现肿胀或水肿。
结论:此外,网络生物学和多药理学结果显示,SOD2、CAT、EPO,IL10,EGF,TGFB1等.在功能性胃肠相关疾病或消化性溃疡中发挥重要作用。因此,该研究得出结论,包括酚类和类黄酮在内的TG多酚在缓解消化性溃疡或相关并发症中起着重要作用,因此证明了TG作为一种天然的治疗方案,可以预防溃疡。
BACKGROUND: Peptic ulcer is a condition characterized by open sores resulting from excessive acid production in the stomach or digestive tract, causing damage to the mucosal lining. Tamarix gallica (TG), is traditionally known for its anti-inflammatory, antioxidant, antibacterial activity, etc. Objective: The scientific evidences based on its efficacy specifically for anti-ulcers activity are limited, hence, the study aimed to evaluate protective effect of TG against aspirin-induced peptic ulcers.
METHODS: Phytochemical screening was performed followed by assessment of protective effect of TG against aspirin induced toxicity in rats. Network biology and polypharmacology studies were performed to determine the possible molecular targets involved in pathophysiology of ulcers.
RESULTS: The study revealed that the TG extract at high dose (500 mg/kg b.w.) significantly exhibits protective effect against aspirin induced ulcers via regulation of free acidity pepsin production, overall acidity via regulating antioxidant status (SOD, GSH, CAT, etc). Morphological studies revealed less damage with less disruption of the gastric mucosa layer having normal mucosal structure, no swelling or oedema was found in drug treated groups.
CONCLUSIONS: Moreover, network biology and polypharmacology outcomes revealed that SOD2, CAT, EPO, IL10, EGF, TGFB1 etc. play a significant role in functional gastrointestinal-associated disease or peptic ulcer. Hence, the study concludes that TG polyphenols including phenols and flavonoids play an important role in alleviation of peptic ulcer or associated complication and thus demonstrating TG as a natural therapeutic regimen against ulcers in glance of nature.