血清铁蛋白水平升高是铁超负荷综合征的常见表现,自身免疫性和病毒性肝炎,酒精性和非酒精性脂肪性肝病。除了铁过载综合征外,高转铁蛋白饱和度在上述疾病中并不常见。我们遇到了一个具有挑战性的案例,73岁的女性出现了淡黄色的皮肤变色,深色尿液和腹部隐痛。初步实验室检查报告轻度贫血;胆红素升高,肝酶,和转铁蛋白饱和度。经过广泛的检查,我们得出了自身免疫性肝炎的最终诊断。自身免疫性肝炎是一种罕见的疾病,铁过载综合征的类似表现可能使诊断更加复杂。显著升高的转铁蛋白饱和度可以模拟铁过载综合征,但是肝活检可以指导医生指导诊断。
Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation. We came to the final diagnosis of autoimmune hepatitis after extensive workups. Autoimmune hepatitis is a rare disease, and the diagnosis can be further complicated by a similar presentation of iron overload syndrome. Markedly elevated transferrin saturation can simulate iron overload syndrome, but a liver biopsy can guide physicians to navigate the diagnosis.