■联合抗肥胖药物（AOM）治疗术后减重手术体重恢复的临床使用数据有限。了解该队列中的最佳治疗方案将最大程度地减轻体重。
■对减肥手术患者（N=44）的回顾性研究，这些患者在一个学术多学科肥胖中心接受了AOM（s）和强化生活方式的调整，为期12个月。
■年龄：28-76岁，93%女性,平均体重110.2±20.3kg，BMI39.7±7.4kg/m2，减重手术后5.2±1.6年[27（61.4%），14（31.8%），和3（6.8％）腹腔镜Roux-en-Y胃旁路术（RYGB），腹腔镜垂直袖状胃切除术(VSG),打开RYGB,分别]，从最低点开始平均体重增加15.1±11.1公斤。医疗干预后的平均体重减轻在3,6-，12个月的时间点为4.4±4.6kg，7.3±7.0kg,10.7±9.2公斤，分别。12个月时,规定3个或更多AOM的个体比规定的个体体重减轻更多（-14.5±9.0kgvs.-4.9±5.7kg,p<0.05)与年龄无关，性别,合并症的数量，初始体重或BMI，手术类型,或GLP1使用。RYGB患者总体体重减轻（7.4%vs.VSG分别为14.8%；p<0.05）。
■可能需要组合AOM以达到最佳的减肥效果，以治疗术后体重恢复。
UNASSIGNED: Combination anti-obesity medications (AOMs) to treat postoperative bariatric surgery weight regain have limited data on their use in the clinical setting. Understanding the optimal treatment protocol in this cohort will maximize weight loss outcomes.
UNASSIGNED: A retrospective review of bariatric surgery patients (N = 44) presenting with weight regain at a single academic multidisciplinary obesity center who were prescribed AOM(s) plus intensive lifestyle modification for 12 months.
UNASSIGNED: Age: 28-76 years old, 93% female, mean weight 110.2 ± 20.3 kg, BMI 39.7 ± 7.4 kg/m2, presenting 5.2 ± 1.6 years post-bariatric surgery [27 (61.4%), 14 (31.8%), and 3 (6.8%) laparoscopic Roux-en-Y gastric bypass (RYGB), laparoscopic vertical sleeve gastrectomy (VSG), and open RYGB, respectively], with 15.1 ± 11.1 kg mean weight gain from nadir. Mean weight loss after medical intervention at 3-, 6-, and 12-month time points was 4.4 ± 4.6 kg, 7.3 ± 7.0 kg, and 10.7 ± 9.2 kg, respectively. At 12 months, individuals prescribed 3 or more AOMs lost more weight than those prescribed one (-14.5 ± 9.0 kg vs. -4.9 ± 5.7 kg, p < 0.05) irrespective of age, gender, number of comorbidities, initial weight or BMI, type of surgery, or GLP1 use. RYGB patients lost less weight overall (7.4% vs. 14.8% VSG respectively; p < 0.05).
UNASSIGNED: Combination AOMs may be needed to achieve optimal weight loss results to treat post-operative weight regain.
PDF(Pubmed)