我们报告了一种有效且环保的方法,该方法可在室温下在水中用Vitreoscha血红蛋白(VHb)催化合成苯并恶唑。叔丁基过氧化氢和2,2,6,6-四甲基-1-哌啶基氧基用作氧化剂和自由基清除剂,分别。通过在VHb存在下在1小时内将酚与胺进行环化反应,以中等至高收率(62%-94%)制备了总共27种功能不同的苯并恶唑。因此,这种方法在实际应用中具有很高的可行性。这项工作拓宽了血红蛋白在有机合成中的应用。
We report an efficient and eco-friendly method for the Vitreoscilla hemoglobin (VHb)-catalyzed synthesis of benzoxazoles in water at room temperature. tert-Butyl hydroperoxide and 2,2,6,6-tetramethyl-1-piperidinyloxy were used as oxidant and radical scavenger, respectively. A total of 27 functionally diverse benzoxazoles were prepared in moderate to high yields (62 %-94 %) by the annulation reaction of phenols with amines in the presence of VHb in 1 h. Thus, this method is highly viable for practical applications. This work broadens the application of hemoglobin to organic synthesis.