我们确定了生化稳态主要系统调节因子的天然抗体(n-Abs):β-内啡肽,血清素,多巴胺,组胺,孤儿,血管紧张素,GABA,谷氨酸,缓激肽,血管加压素,凝血酶,和α-2-巨球蛋白在幻痛综合征(PPS)患者中,受伤后截肢。已经确定每个患者都有单独的免疫图谱,但是对于所有这些人来说,血清素的抗体水平显着增加,组胺,还有血管紧张素,这反映了疼痛综合征的慢性,不依赖于PPS严重程度的自我评估。生化稳态调节剂在幻痛发展中的作用的测定表明,在高,中度,PPS的严重程度较弱,生物胺和血管紧张素能系统被激活。PPS强度的降低使所有免疫学参数的偏差正常化。疼痛(β-内啡肽)和镇痛(孤儿)系统的n-Ab水平仅在低PPS时才显着。监测内源性调节因子的n-Abs的个体特征使我们能够获得患者身体疼痛状态的客观图像。
We determined natural antibodies (n-Abs) to the regulators of the main systems of biochemical homeostasis: β-endorphin, serotonin, dopamine, histamine, orphanin, angiotensin, GABA, glutamate, bradykinin, vasopressin, thrombin, and α-2-macroglobulin in individuals with phantom pain syndrome (PPS), resulting from amputation after injury. It was established that each patient has an individual immunoprofile, but for all of them there was a significant increase in the level of antibodies to serotonin, histamine, and angiotensin, which reflect the chronicity of the pain syndrome and do not depend on the self-assessment of the severity of PPS. Determination of the role of regulators of biochemical homeostasis in the development of phantom pain showed that, at high, moderate, and weak severity of PPS, the biogenic amine and angiotensinergic systems are activated. A decrease in PPS intensity normalizes deviations in all immunological parameters. The levels of n-Abs for the pain (β-endorphin) and analgesic (orphanin) systems are significant only at low PPS. Monitoring the individual profile of n-Abs to endogenous regulators allows us to obtain an objective picture of the pain status of the patient\'s body.