特发性快速眼动睡眠行为(iRBD)被认为是帕金森病(PD)发展的危险因素。手指敲击重复动作的评价,作为测量PD运动迟缓程度的主要任务,可能会发现潜在的PD患者。这项研究的目的是探讨手指敲击是否异常,用3D运动捕捉系统评估,已经存在于RBD患者中。
使用非接触式3D运动捕获系统从40名RBD受试者获得手指敲击数据,并与25名新生PD患者和25名健康对照进行比较。振幅衰减的客观评估,在前十次敲击运动的顺序中执行了表示手指敲击递减的最大打开速度及其组合。分析了仪器手指敲击数据与半定量临床评估之间的关联。
虽然在所有调查的手指敲击措施中发现PD和对照组之间存在显着差异(p<0.002),RBD在手指敲击幅度(p=0.004)和速度(p=0.007)下降方面与控件不同,但在最大打开速度方面没有差异。两组患者的运动障碍协会-帕金森病统一评定量表的运动评分与手指敲击减少之间存在显着关系,即RBD(r=0.36,p=0.02)和PD(r=0.60,p=0.002)。
在我们组的RBD患者中,我们证明了重复运动的幅度减小,这可能与前驱运动迟缓相对应。我们的发现表明,手指敲击异常的仪器分析是反映RBD亚临床运动障碍的潜在新型临床标志物。
Idiopathic rapid eye movement sleep behaviour (iRBD) is considered as a risk factor for Parkinson\'s disease (PD) development. Evaluation of repetitive movements with finger tapping, which serves as a principal task to measure the extent of bradykinesia in PD, may undercover potential PD patients. The aim of this study was to explore whether finger tapping abnormalities, evaluated with a 3D motion capture system, are already present in RBD patients.
Finger tapping data was acquired using a contactless 3D motion capture system from 40 RBD subjects and compared to 25 de-novo PD patients and 25 healthy controls. Objective assessment of amplitude decrement, maximum opening velocity and their combination representing finger tapping decrement was performed in the sequence of the first ten tapping movements. The association between instrumental finger tapping data and semi-quantitative clinical evaluation was analyzed.
While significant differences between PD and controls were found for all investigated finger tapping measures (p < 0.002), RBD differed from controls in finger tapping amplitude (p = 0.004) and velocity (p = 0.007) decrement but not in maximal opening velocity. A significant relationship between the motor score from the Movement Disorders Society - Unified Parkinson\'s Disease Rating Scale and finger tapping decrement was shown for both patient groups, ie RBD (r = 0.36, p = 0.02) and PD (r = 0.60, p = 0.002).
In our group of RBD patients we demonstrated amplitude decrement of repetitive movements, which may correspond with prodromal bradykinesia. Our findings suggest instrumental analysis of finger tapping abnormalities as a potential novel clinical marker reflecting subclinical motor disturbances in RBD.