目的:PCOS代谢异常和卵巢功能障碍的根本原因被认为是慢性低度炎症。本研究旨在显示α-1-酸性糖蛋白(AGP)炎症标记物,预测患有PCOS的可育和不育女性的不孕风险。我们的研究采用了cross分段病例对照设计。
方法:我们的研究纳入了20名想要孩子的PCOS可育和50名不育患者,这些患者处于早期卵泡期。在研究组(fertil(n=20)和不育(n=50)中,AGP,CRP,NLR,BMI,FAI,VAI,甘油三酯,HDL-胆固醇,空腹血糖,HOMA-IR,SHBG,测量睾酮值和腰围。
结果:在研究中纳入的可育和不育组的炎症标志物中,只有AGP变量之间的差异有统计学意义(p=0.011).在不育组中,发现平均AGP在统计学显著水平上较高(p<0.05)。年龄,BMI,不育组腰围和AGP呈弱阳性,CRP呈中度阳性(p<0.05)。
结论:AGP可能是PCOS炎症的良好指标,尤其是不孕症。通过AGP测量揭示PCOS不孕的风险可能有助于正确管理生殖过程。
OBJECTIVE: The underlying cause of metabolic abnormalities and ovarian dysfunction in PCOS is thought to be chronic low-grade inflammation. This study aimed to show whether alpha-1-acid glycoprotein (AGP), an inflammatory marker, predicts the risk of infertility in fertile and infertile women with PCOS. Our study had a cros-sectional case-control design.
METHODS: A total of 20 fertile and 50 infertile patients with PCOS who wanted a child were in the early follicular phase were included in our study. Among the study groups (fertil (n = 20) and infertile (n = 50), AGP, CRP, NLR, BMI, FAI, VAI, triglyceride, HDL-cholesterol, fasting blood sugar, HOMA-IR, SHBG, testosterone values and waist circumference were measured.
RESULTS: Among the inflammatory markers compared in the fertile and infertile groups included in the study, only the difference between the AGP variable was statistically significant (p = 0.011). The mean AGP was found to be higher at a statistically significant level in the infertile group (p < 0.05). Age, BMI, waist circumference and AGP were weakly positive and CRP was moderately positive in the infertile group (p < 0.05).
CONCLUSIONS: AGP can be a good indicator of inflammation in PCOS, especially in infertility.Revealing the risk of infertility in PCOS with AGP measurement may contribute to the correct management of the reproductive process.