目的:在观察性研究中发现过敏性疾病和梅尼埃病可能存在联系。然而,两者之间潜在的因果关系尚不清楚.因此,我们的目的是使用一种称为双向孟德尔随机研究的新数据分析技术,探讨过敏性疾病和梅尼埃病之间的因果关系.
方法:梅尼埃病和三种过敏性疾病(哮喘,过敏性鼻炎,湿疹/皮炎)是从大规模全基因组关联研究中获得的。采用逆方差加权法作为主要测度,辅以MR-Egger回归和加权中位数法。为保证结论的可靠性,Cochran\'sQ,MR-Egger截获,MR-PRESSO试验,漏检,使用MRSteiger测试。
结果:逆方差加权方法显示哮喘(p=0.008,OR=3.908,95%CI1.424-10.724,调整p=0.024),过敏性鼻炎(p=0.026,OR=24.714,95%CI1.479-412.827,调整p=0.026)和湿疹/皮炎(p=0.019,OR=3725.954,95%CI3.795至3,658,399.580,调整p=0.029)均对梅尼埃病具有显着影响。反向孟德尔随机化研究表明,梅尼埃病不会增加三种过敏性疾病的风险。敏感性分析显示每个性状没有水平多效性和异质性。
结论:我们的孟德尔随机分析支持三种过敏性疾病(哮喘,过敏性鼻炎,湿疹/皮炎)和梅尼埃病。这表明医生应该更加关注梅尼埃患者的过敏史,并将避免过敏作为治疗计划的一部分。
方法:孟德尔随机(MR)研究在证据水平上仅次于随机对照试验。
OBJECTIVE: Allergic diseases and Meniere\'s disease found to have a possible link in observational study. However, the potential causal relationship between the two is unclear. Therefore, we aimed to explore the causal relationship between allergic diseases and Meniere\'s disease using a new data analysis technique called bidirectional Mendelian randomization study.
METHODS: Summary-level statistics for Meniere\'s disease and three allergic diseases (asthma, allergic rhinitis, eczema/dermatitis) were obtained from large-scale genome-wide association studies. The inverse variance weighted method was used as the primary measure, supplemented by MR-Egger regression and the weighted median method. To ensure the reliability of the conclusions, Cochran\'s Q, MR-Egger intercept, MR-PRESSO test, leave-one-out test, and MR Steiger test were used.
RESULTS: Inverse-variance weighted method showed asthma (p = 0.008, OR = 3.908, 95% CI 1.424-10.724, adjust_p = 0.024), allergic rhinitis (p = 0.026, OR = 24.714, 95% CI 1.479-412.827, adjust_p = 0.026) and eczema/dermatitis (p = 0.019, OR = 3725.954, 95% CI 3.795 to 3,658,399.580, adjust_p = 0.029) all had a significant effect on Meniere\'s disease. Reverse Mendelian randomization studies have shown that Meniere\'s disease does not increase the risk of three allergic diseases. Sensitivity analysis showed no horizontal pleiotropy and heterogeneity for each trait.
CONCLUSIONS: Our Mendelian randomization analysis supports a positive causal relationship between three allergic diseases (asthma, allergic rhinitis, eczema/dermatitis) and Meniere\'s disease. This suggests that physicians should pay more attention to the Meniere\'s patient\'s allergy history and consider allergy avoidance as part of their treatment plan.
METHODS: Mendelian Randomized (MR) studies are second only to randomized controlled trials in terms of the level of evidence.