目的:开发了一种新型外用乳膏来解决眶周皮肤老化的问题。本研究的目的是评估该产品的疗效和耐受性(TotalEye®公司和修复霜;Colorescience,Inc.,卡尔斯巴德,CA)用于改善眶周皱纹,干燥度,松弛,和黑眼圈。
方法:这项为期8周的开放标签试验招募了35-65岁寻求眼周年轻化的受试者(N=25;22名女性,3男)。在面部清洁后每天早晚施用该产品。研究终点是研究者临床分级和眼部外观评估的变化,受试者自我评估问卷,治疗4周和8周后的耐受性。
结果:在完成研究的受试者中(n=23),所有患者(100%)在第4周和第8周都出现了一些全球性的改善,几乎一半(48%)达到了中度或显著的改善.所有参数都观察到改善,皱纹最明显,松弛,和黑眼圈。在第4周时松弛和干燥的改善是显著的,在第8周时黑眼圈的改善是显著的。在第8周,受试者同意或强烈同意该产品使他们的眼睛感觉更多的水分(100%),外观和感觉更健康(95%),并增加了对眼睛外观的信心(91%)。该产品耐受性良好。
结论:受试者数量适中,开放标签研究设计。
结论:每日两次TotalEye®公司&修复霜改善了眶周区域的整体外观。该产品具有良好的耐受性,大多数接受治疗的受试者对其结果感到满意。该产品是治疗眶周皱纹和松弛的可行选择,应被视为安全有效的护肤选择。
OBJECTIVE: A novel topical cream was developed to address the appearance of aging periorbital skin. The goal of this study was to evaluate the efficacy and tolerability of this product (Total Eye® Firm & Repair Cream; Colorescience, Inc., Carlsbad, CA) for improving periorbital wrinkles, dryness, laxity, and dark circles.
METHODS: This 8-week open-label trial enrolled subjects 35-65 years old seeking periocular rejuvenation (N = 25; 22 female, 3 male). The product was applied each morning and evening after facial cleansing. Study endpoints were changes in Investigator Clinical Grading and Eye Appearance Assessments, Subject Self-assessment Questionnaires, and tolerability after 4 and 8 weeks of treatment.
RESULTS: Among subjects completing the study (n = 23), all (100%) showed some global improvement at Weeks 4 and 8 and almost half (48%) achieved moderate or marked improvement. Improvements were observed for all parameters and were most pronounced for wrinkles, laxity, and dark circles. Improvements for laxity and dryness were significant by Week 4 and for dark circles by Week 8. At Week 8, subjects agreed or strongly agreed that the product made their eyes feel more hydrated (100%), look and feel healthier (95%), and increased confidence in their eye appearance (91%). The product was well-tolerated.
CONCLUSIONS: Modest number of subjects and open-label study design.
CONCLUSIONS: Twice-daily Total Eye® Firm & Repair Cream improved the overall appearance of the periorbital area. The product was well-tolerated and most treated subjects were satisfied with their results. The product is a viable option for treating periorbital wrinkles and laxity and should be considered a safe and effective skincare option.