软袋复合体(FPC)由回肠袋患者的疾病表型组成,包括眼袋脱垂,传入肢体综合征,肠膨出,冗余环路,和袋子折叠。我们最近的研究表明,较低的体重,较低的周袋脂肪,炎症性肠病(IBD)家族史,女性性别,室性痴呆是FPC患者IBD的危险因素。本研究的目的是评估袋壁厚度和FPC之间的关系,并研究发炎和非发炎的小袋壁厚之间的关系。
这项病例对照研究纳入了我们前瞻性维持的所有符合条件的FPC患者,IRB于2011年至2017年批准了PouchitisRegistry。我们在横截面腹部和骨盆成像上测量了完全扩张的小袋的小袋壁厚。造口和非扩张袋的患者被完全排除在外。分析FPC的危险因素。
在我们的451名患者中,共有140名患者在成像时发现袋完全扩张。140名患者中,36例(25.7%)被诊断为FPC。我们分析了FPC的每个子类别以及非FPC条件的小袋壁厚。小袋壁的厚度如下:小袋脱垂(N=19):1.5mm(1.5-2.0),传入肢体综合征(N=12):1.5毫米(1.1-2.0),折叠袋(N=4):1.5毫米(1.1-1.9),和冗余袋(N=2):1.3毫米(1.0-1.3)。对照组(N=104)由正常囊组成,囊炎,Cuffitis,克罗恩病的袋,和袋窦,中位袋壁厚为1.5毫米,2.3mm,2.0mm,2.0mm,和1.5毫米,分别。正常或未发炎的小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋,小袋小袋,小袋小袋,小袋小袋小袋,小袋小袋小袋小袋小
FPC患者的囊壁薄,那些有炎症条件的小袋倾向于有厚的小袋壁。这些发现将对这些疾病的病因的诊断和研究都有影响。
Floppy pouch complex (FPC) consists of disease phenotypes in patients with ileal pouches, including pouch prolapse, afferent limb syndrome, enterocele, redundant loop, and pouch folding. Our recent study demonstrated that lower body weight, lower peripouch fat, family history of inflammatory bowel disease (IBD), female gender, and dyschezia are risk factors for FPC patients with IBD. The aims of this study were to assess the relationship between pouch wall thickness and FPC, and to investigate the association between inflamed and non-inflamed pouch wall thickness.
This case-control study included all eligible patients with FPC from our prospectively maintained, IRB-approved Pouchitis Registry from 2011 to 2017. We measured pouch wall thickness of fully distended pouches on cross-sectional abdominal and pelvic imaging. Patients with stoma and non-distended pouches were completely excluded. Risk factors for FPC were analyzed.
A total of 140 out of 451 patients from our were found to have fully distended pouches on imaging. Of the 140 patients, 36 (25.7%) were diagnosed as having FPC. We analyzed pouch wall thickness for each subcategory of FPC as well as non-FPC conditions. The thickness of pouch wall was follows: pouch prolapse (N = 19): 1.5 mm (1.5-2.0), afferent limb syndrome (N = 12): 1.5 mm (1.1-2.0), folded pouch (N = 4): 1.5 mm (1.1-1.9), and redundant pouch (N = 2): 1.3 mm (1.0-1.3). The control group (N = 104) consisting of normal pouch, pouchitis, cuffitis, Crohn\'s disease of the pouch, and pouch sinus with median pouch wall thickness of 1.5 mm, 2.3 mm, 2.0 mm, 2.0 mm, and 1.5 mm, respectively. There were significant differences in pouch wall thickness between normal or non-inflamed pouch versus pouchitis versus cuffitis versus Crohn\'s disease of the pouch with p values of 0.01, 0.04, 0.05, and 0.049, respectively.
Patients with FPC were shown to have thin pouch wall, which those with inflammatory conditions of the pouch tended to have thick pouch wall. These findings will have implications in both diagnosis and investigation of etiopathogenesis of these disorders.