目的:考虑到芝麻油治疗皮肤病的抗炎和积极作用,本研究旨在研究其对此类患者急性放疗性皮炎的治疗效果。
方法:将40例乳腺癌患者在放疗期间(5周)随机分为两类:芝麻油(20例)和安慰剂(20例)。每次放疗后,他们被要求在治疗场上使用3cc的软膏,并继续治疗直到结束。根据肿瘤放射治疗组的分期标准每周检查一次。
结果:在前3周没有观察到显著差异。在第四周,0级皮炎为35%,1级为65%,在干预(病例)组中,2级为0%,而在对照组中,他们是10%,75%,15%,分别。这种差异具有统计学意义(p=0.046)。此外,在案件组的第五周,0级皮炎为25%,一级是70%,二级是5%,而在对照组中,他们是0%,80%,20%,分别。这种差异也是统计学上显著的(p=0.032)。
结论:根据调查结果,芝麻油,作为一种廉价和可用的草药治疗,可用于治疗由放射治疗引起的急性皮炎。然而,应在几个中心进行更大样本量的调查,以更全面地检查芝麻油治疗急性放射性皮炎的效果。
OBJECTIVE: Considering the anti-inflammatory and positive effects of sesame oil in treating skin diseases, the present research aimed to study its therapeutic effects on acute radiotherapy dermatitis in such patients.
METHODS: Forty women with breast cancer during radiotherapy (for 5 weeks) were randomly grouped into two categories: sesame oil (20 patients) and placebo (20 patients). After each radiotherapy session, they were asked to use 3cc of the ointment on the treating field and continue the treatment until the end. They were examined weekly according to the staging criteria of the radiation therapy oncology group.
RESULTS: No significant difference was observed in the first 3 weeks. In the fourth week, dermatitis grade 0 was 35%, grade 1 was 65%, and grade 2 was 0% in the intervention (case) group, while in the control group, they were 10%, 75%, and 15%, respectively. This difference was statistically significant (p = 0.046). Also, in the fifth week in the case group, dermatitis grade 0 was 25%, grade 1 was 70%, and grade 2 was 5%, while in the control group, they were 0%, 80%, and 20%, respectively. This difference was also statistically significant (p = 0.032).
CONCLUSIONS: Based on the findings, sesame oil, as a cheap and available herbal treatment, may be utilized in treating acute dermatitis caused by radiotherapy. However, an investigation with a larger sample size in several centers should be conducted to examine sesame oil effects in treating acute radio dermatitis more comprehensively.