目的:这项初步研究的目的是利用声学语音质量指数(AVQI)和声学呼吸指数(ABI)检查早期帕金森病(PD)患者的语音质量变化。
方法:随访研究。
方法:基线和随访数据来自PDSTUlong语音语料库。这两个时间点的数据包括:演讲者背景信息,持续的元音,阅读样本,和PD严重程度的测量(Hoehn和Yahr评分和统一帕金森病评定量表III评分[UPDRS-III])。所有演讲者(N=12)都是芬兰语母语人士。AVQIv03.01和ABI分析在VOXplotv2.0.1中完成。通过因果分析检查基线和随访之间的AVQI和ABI评分的变化。Further,分析了AVQI和ABI与PD严重程度的关系。
结果:基线平均AVQI评分为1.79(范围为0.14-4.83,SD=1.60),而随访平均AVQI评分为2.25(范围0.55-4.53,SD=1.36)。基线平均ABI得分,反过来,为2.92(范围1-27-5.31,SD=1.57),而随访平均ABI评分为3.42(范围为1.40-5.40,SD=1.38)。AVQI(Z=-2.002,P=0.045)和ABI(Z=-2.197,P=0.028)的基线和随访指标之间存在显著差异。在两个测量周期之间,平滑的倒频谱峰突出度(Z=-2.118,P=0.034)和谐波噪声比(Z=-1.961,P=0.050)也存在显着差异。AVQI和ABI的变化与PD严重程度的变化无关。
结论:在大约1年内,在AVQI和ABI评分中观察到统计学变化,即使在这么小的数据集中。呼吸和声音嘶哑的具体品质表现出最显着的进展。语音质量的变化在ABI分析中更为突出。
OBJECTIVE: The purpose of this pilot study was to examine voice quality changes in individuals with early-stage Parkinson\'s disease (PD) utilizing the Acoustic Voice Quality Index (AVQI) and Acoustic Breathiness Index (ABI) over approximately a 1-year period.
METHODS: Follow-up study.
METHODS: Baseline and follow-up data were gathered from the PDSTUlong speech corpus. The data for both time points included: speaker background information, sustained vowels, reading samples, and measures of PD severity (Hoehn and Yahr scores and Unified Parkinson\'s Disease Rating Scale III scores [UPDRS-III]). All speakers (N = 12) were native Finnish speakers. AVQIv03.01 and ABI analysis were completed in VOXplot v2.0.1. Changes in AVQI and ABI scores between baseline and follow-up were examined via causal analysis. Further, AVQI and ABI were analyzed in relation to measures of PD severity.
RESULTS: Baseline mean AVQI score was 1.79 (range 0.14-4.83, SD=1.60), whereas follow-up mean AVQI score was 2.25 (range 0.55-4.53, SD=1.36). Baseline mean ABI score, in turn, was 2.92 (range 1-27 - 5.31, SD=1.57), whereas follow-up mean ABI score was 3.42 (range 1.40-5.40, SD=1.38). A significant difference was found between baseline and follow-up measures for both AVQI (Z = -2.002, P = 0.045) and ABI (Z = -2.197, P = 0.028). A significant difference in smoothed cepstral peak prominence (Z = -2.118, P = 0.034) and harmonics-to-noise ratio (Z = -1.961, P = 0.050) was also found between the two measurement periods. Change in AVQI and ABI were not correlated with the change in measures of PD severity.
CONCLUSIONS: Over approximately 1-year, a statistical change was observed in AVQI and ABI scores, even in such a small dataset. The specific qualities of breathiness and hoarseness showed the most significant progression. Changes in voice quality were more prominent in ABI analysis.