背景:局部治疗是痤疮的主要治疗方法,和局部类维生素A,如维甲酸,他扎罗汀,和阿达帕林被推荐作为轻中度痤疮的一线治疗。然而,皮肤可能会刺激,建议使用皮肤化妆品以防止抗痤疮药物的副作用并坚持治疗。因此,本研究旨在比较含神经酰胺和烟酰胺的保湿剂(CCM)与亲水乳膏联合局部抗痤疮治疗对轻度至中度寻常痤疮的疗效和耐受性.
方法:这是一个8周,随机化,双盲,对40名接受局部抗痤疮药物治疗(5%过氧化苯甲酰和0.1%阿达帕林凝胶)的患者进行分面研究,然后随机应用CCM或亲水乳膏。在第0、2、4和8周随访所有患者的痤疮改善情况,不良反应,生物识别,和生物物理评估。
结果:CCM能显著改善非炎症,炎症,治疗第8周后,与亲水性乳膏相比,痤疮总病变。有趣的是,全球最差分数有所改善,血红蛋白指数,黑色素指数,TEWL,皮肤水合作用,皮脂生产,和皮肤表面的pH值,两种治疗方法之间无统计学差异。临床应用CCM和亲水乳膏对轻中度寻常痤疮患者无严重副作用。
结论:含神经酰胺和烟酰胺的保湿剂与抗痤疮药物联合使用可以显着改善痤疮病变并减少皮肤刺激,从而获得满意的轻度至中度寻常痤疮治疗效果。
BACKGROUND: Topical therapy is the mainstay treatment of acne, and topical retinoids such as tretinoin, tazarotene, and adapalene are recommended as the first-line therapy for mild to moderate acne. However, the cutaneous irritations may occur, and the dermocosmetics are recommended to prevent side effects of anti-acne drugs and adhere to treatment. Thus, this study aims to compare the efficacy and tolerability of ceramides and niacinamide-containing moisturizer (CCM) versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris.
METHODS: This was an 8-week, randomized, double-blinded, split face study in 40 patients assigned for topical anti-acne medications (5% benzoyl peroxide and 0.1% adapalene gel), then randomly applied CCM or hydrophilic cream. All patients were followed at week 0, 2, 4, and 8 for acne improvement, adverse reactions, biometric, and biophysical evaluation.
RESULTS: CCM could significantly improve the non-inflammatory, inflammatory, and total acne lesions compared with hydrophilic cream after week 8 of treatment. Interestingly, there was an improvement of global worst score, hemoglobin index, melanin index, TEWL, skin hydration, sebum production, and skin surface pH, with no statistically significant differences between the two treatments. No serious side effects from clinical application of CCM and hydrophilic cream in mild to moderate acne vulgaris patients.
CONCLUSIONS: Ceramide and niacinamide-containing moisturizer in combination with anti-acne medication can significantly improve acne lesions and decrease cutaneous irritations toward a satisfactory treatment outcome of mild to moderate acne vulgaris.