寻常痤疮,通常称为痤疮,是一种影响全球许多人的皮肤状况。这是一种慢性疾病,其特征是发展为丘疹,黑头(开放的粉刺),白头(闭合粉刺),和其他皮肤损伤。痤疮通常出现在脸上,脖子,胸部,和回来。它通常与青春期和青春期有关,但也可能影响所有年龄段的成年人。痤疮可能非常令人沮丧和尴尬,导致自卑和社会孤立。这种情况是由各种因素引起的,包括毛孔堵塞,过多的皮脂生产,细菌,和炎症。这项系统评价评估了局部抗生素的有效性。类维生素A,烟酰胺,壬二酸,和克拉维酮治疗轻度至中度寻常痤疮。跨PubMed的全面搜索,PubMedCentral,谷歌学者发表了10篇专注于局部抗生素的文章,198名受试者的研究结果表明多西环素对炎性病变的疗效。维甲酸,比如维甲酸和阿达帕林,显着改善两种病变类型(开放性和闭合性粉刺)。烟酰胺,在一项涉及41名参与者的随机对照试验中进行了检查,减少皮脂生产。另一项对60名患者的研究表明,壬二酸可有效减少炎症和非炎性病变。Clascoterone成为一种有前途的抗雄激素治疗方法,由一项涉及4,440例患者的随机对照试验支持.个性化治疗至关重要,结合患者的偏好并考虑不利影响,强调优化痤疮管理。
Acne vulgaris, commonly called acne, is a skin condition affecting many individuals globally. It is a chronic condition characterized by developing pimples, blackheads (open comedones), whiteheads (closed comedones), and other skin lesions. Acne usually appears on the face, neck, chest, and back. It is commonly associated with puberty and adolescence but can also affect adults of all ages. Acne can be very frustrating and embarrassing, leading to low self-esteem and social isolation. The condition arises from various factors, including clogged pores, excessive sebum production, bacteria, and inflammation. This systematic review assesses the effectiveness of topical antibiotics, retinoids, niacinamide, azelaic acid, and clascoterone in treating mild-to-moderate acne vulgaris. A comprehensive search across PubMed, PubMed Central, and Google Scholar yielded 10 articles focused on topical antibiotics, with findings from 198 subjects indicating the efficacy of doxycycline against inflammatory lesions. Retinoids, such as tretinoin and adapalene, significantly improved both lesion types (open and closed comedones). Niacinamide, examined in a randomized controlled trial involving 41 participants, reduced sebum production. Another study with 60 patients revealed that azelaic acid effectively reduced both inflammatory and non-inflammatory lesions. Clascoterone emerged as a promising antiandrogenic treatment, supported by a randomized controlled trial involving 4,440 patients. It is essential that individualized therapy, incorporating patient preferences and considering adverse effects, is emphasized for optimizing acne management.