■本研究旨在检查膳食酸负荷(DAL)与炎症标志物之间的关联,氧化应激,一组伊朗血液透析(HD)患者的营养不良。
这项横断面研究是对年龄≥18岁、在纳入研究前至少6个月接受HD治疗的个体进行的。4天的饮食召回用于评估饮食摄入量。使用两种方法计算DAL,包括潜在的肾酸负荷(PRAL)和净内源性酸产生(NEAP)。为了评估营养不良状况,我们使用了主观全局评估(SGA),透析营养不良评分(DMS),和营养不良炎症评分(MIS)。收集每位参与者的空腹血样,以评估高敏C反应蛋白(hs-CRP)的血清水平。可溶性细胞间粘附分子-1(sICAM-1),可溶性血管粘附分子-1(sVCAM-1),sE-选择素,丙二醛(MDA),一氧化氮(NO),和内皮素-1.
■总共,本研究纳入291例患者,平均年龄为57.73±0.88岁,HD年份为4.27±0.25个月。在PRAL和hs-CRP之间观察到显着的正相关(β=1.77,95%CI:0.88,2.65),sICAM-1(β=83.21,95%CI:10.39,156.04),sVCAM-1(β=194.63,95%CI:74.68,314.58),和sE-选择素(β=6.66,95%CI:1.81,11.50)在PRAL得分最高的参与者中,与PRAL得分最低的人相比。NEAP与hs-CRP呈正相关(β=1.34,95%CI:0.46,2.22),sICAM-1(β=88.83,95%CI:16.99,160.67),和丙二醛(β=0.35,95%CI:0.005,0.71)。此外,SGA(OR=1.98,95%CI:0.95,4.11)和DMS(OR=1.94,95%CI:0.92,4.05)的几率稍高。PRAL的第一个三元组。NEAP与DMS也呈显著正相关(OR=2.01,95%CI:0.93,4.31)。
■这项研究表明,酸性食物的消费量增加与炎症标志物相关,氧化应激,和营养不良的HD患者。
UNASSIGNED: The present study was conducted to examine the association between dietary acid load (DAL) and markers of inflammation, oxidative stress, and malnutrition in a group of Iranian hemodialysis (HD) patients.
UNASSIGNED: This cross-sectional study was performed on individuals aged ≥18 years who were on HD at least 6 months before their enrollment in the study. A 4-day dietary recall was used for the evaluation of dietary intake. DAL was calculated using two methods including potential renal acid load (PRAL) and net endogenous acid production (NEAP). For assessing the malnutrition status, we used the subjective global assessment (SGA), dialysis malnutrition score (DMS), and malnutrition inflammation score (MIS). Fasting blood samples were collected from each participant to assess serum levels of high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), sE-selectin, malondialdehyde (MDA), nitric oxide (NO), and endothelin-1.
UNASSIGNED: In total, 291 patients with a mean age of 57.73 ± 0.88 years and HD vintage of 4.27 ± 0.25 months were enrolled in the current study. Significant positive associations were observed between PRAL and hs-CRP (β = 1.77, 95% CI: 0.88, 2.65), sICAM-1 (β = 83.21, 95% CI: 10.39, 156.04), sVCAM-1 (β = 194.63, 95% CI: 74.68, 314.58), and sE-selectin (β = 6.66, 95% CI: 1.81, 11.50) among participants with the highest PRAL scores, compared to those with the lowest PRAL scores. NEAP was positively correlated with hs-CRP (β = 1.34, 95% CI: 0.46, 2.22), sICAM-1 (β = 88.83, 95% CI: 16.99, 160.67), and MDA (β = 0.35, 95% CI: 0.005, 0.71). Additionally, marginally significant higher odds of SGA (OR = 1.98, 95% CI: 0.95, 4.11) and DMS (OR = 1.94, 95% CI: 0.92, 4.05) were observed in individuals in the third tertile of PRAL vs. the first tertile of PRAL. NEAP had also a marginally significant positive correlation with DMS (OR = 2.01, 95% CI: 0.93, 4.31).
UNASSIGNED: This study illustrates that higher consumption of acidic foods is correlated with markers of inflammation, oxidative stress, and malnutrition in HD patients.