未经证实:作为小儿哮喘气道炎症生物标志物的hs-CRP数据很少。我们旨在研究hs-CRP与哮喘控制水平之间的相关性。
未经证实:医生诊断为哮喘的儿童,年龄6-15岁,已注册。GINA-2016标准用于评估哮喘控制水平。血清hs-CRP与各项哮喘控制措施之间的关系(哮喘控制标准,肺活量测定,脉冲振荡法,评估嗜酸性粒细胞计数和呼出气一氧化氮(FeNO)分数。
UNASSIGNED:纳入了150名哮喘儿童;52名(35%)哮喘控制良好,76(51%),和22(14%)儿童部分控制和未控制的哮喘,分别。控制良好的hs-CRP中位数(IQR)为0.47(0.1,1.67)mg/L,部分控制的0.30(0.1,1.83)mg/L,未控制的哮喘患者为2.74(0.55,3.74)mg/L(p=0.029)。采用受试者操作特征(ROC)曲线分析,hs-CRP(mg/L)区分不受控制和(控制+部分控制)哮喘的曲线下面积为0.67(95%CI0.55,0.80),1.1mg/L血清hs-CRP水平的截止值敏感性为68.1%,特异性为67.97%.两组hs-CRP(<3mg/L)和hs-CRP(≥3mg/L),高hs-CRP组未控制哮喘患儿比例较高(p=0.03).
UNASSIGNED:我们观察到哮喘未控制儿童的血清hs-CRP值较高,提示其作为哮喘控制生物标志物的潜在作用。
Data are scarce on hs-CRP as a biomarker for airway inflammation in pediatric asthma. We aimed to examine correlation between hs-CRP and asthma control levels.
Children with physician-diagnosed asthma, ages 6-15 years, were enrolled. GINA-2016 criteria were used to assess the level of asthma control. The relationships between serum hs-CRP and each of asthma control measures (asthma control criteria, spirometry, impulse oscillometry, eosinophil counts and fractional exhaled nitric oxide (FeNO) were assessed.
150 asthmatic children were enrolled; 52 (35%) had well controlled asthma, 76 (51%), and 22 (14%) children had partly controlled and uncontrolled asthma, respectively. Median (IQR) values of hs-CRP were 0.47 (0.1, 1.67) mg/L in well controlled, 0.30 (0.1, 1.83) mg/L in partly controlled, and 2.74 (0.55, 3.74) mg/L in uncontrolled asthma (p = 0.029). Using receiver operator characteristic (ROC) curve analysis, area under the curve for hs-CRP (mg/L) to discriminate between uncontrolled and (controlled + partly controlled) asthma was 0.67 (95% CI 0.55, 0.80) and a cutoff 1.1 mg/L of serum hs-CRP level had a sensitivity of 68.1% with specificity of 67.97%. In two groups of hs-CRP (<3 mg/L) and hs-CRP (≥3 mg/L), high hs-CRP group had higher proportion of uncontrolled asthmatic children (p = 0.03).
We observed higher serum hs-CRP values in children with uncontrolled asthma, suggesting its potential role as a biomarker of asthma control.