abdominal

腹部
  • 文章类型: Journal Article
    背景:在成人中已经报道了体形与抑郁症状之间的关联。本研究旨在调查多地区亚洲成年人身体形态特异性腹部肥胖与抑郁症状之间的关系。
    方法:以2011-2012年中国健康与退休纵向研究和2022-2023年杭州研究为发现和验证数据集,分别。通过BMI类别评估身体形状。腹型肥胖定义为身体形态指数(ABSI)≥75百分位。使用10项流行病学研究中心抑郁量表和老年抑郁量表简短的15项版本测量抑郁,分别。一般线性和多项式逻辑模型用于探索ABSI的关联,腹部肥胖伴抑郁评分和存在,分别。
    结果:共有12,229和1210名参与者被纳入发现和验证数据集,分别。在ABSI和抑郁评分之间发现了非线性反向L形关联。腹型肥胖患者的抑郁评分较高(分别为β=0.05,95CI=0.01-0.09;β=0.13,95CI=0.01-0.24)。分层分析表明,在超重成年人中,腹部肥胖与较高的抑郁评分(分别为β=0.09,95CI=0.00-0.17;和β=0.25,95CI=0.05-0.46)和存在(OR=1.46,95CI=1.02-2.10;和OR=3.95,95CI=1.58-9.84;)相关。此外,腹部肥胖与超重女性的抑郁症状有关,但不是男性。
    结论:由于观察性研究设计,未解决因果关系。
    结论:在亚洲超重成年人中,腹型肥胖与抑郁症状呈正相关,尤其是女性。抑郁症状的预防和早期诊断应侧重于超重女性。
    BACKGROUND: The association between body shape and depressive symptoms has been reported in adults. The present study aimed to investigate the association between body shape-specific abdominal obesity and depressive symptoms among multi-regional Asian adults.
    METHODS: The 2011-2012 China Health and Retirement Longitudinal Study and 2022-2023 Hangzhou study were used as the discovery and validation datasets, respectively. Body shape was assessed by BMI categories. Abdominal obesity was defined as a body shape index (ABSI) ≥ 75th centile. Depression was measured using 10-item Centre for Epidemiological Studies Depression Scale and Geriatric Depression Scale short 15-item version, respectively. General linear and multinomial logistic models were used to explore the association of ABSI, abdominal obesity with depressive scores and presence, respectively.
    RESULTS: A total of 12,229 and 1210 participants were included in the discovery and validation datasets, respectively. A non-linear reverse L-shaped association was found between ABSI and depressive scores. Participants with abdominal obesity had higher depressive scores (β = 0.05, 95%CI = 0.01-0.09; and β = 0.13, 95%CI = 0.01-0.24; respectively). Stratified analyses showed that abdominal obesity was associated with higher depressive scores (β = 0.09, 95%CI = 0.00-0.17; and β = 0.25, 95%CI = 0.05-0.46; respectively) and presence (OR = 1.46, 95%CI = 1.02-2.10; and OR = 3.95, 95%CI = 1.58-9.84; respectively) in overweight adults. Furthermore, abdominal obesity was associated with depressive symptoms among overweight females, but not among males.
    CONCLUSIONS: Causal links weren\'t addressed because of the observational study design.
    CONCLUSIONS: Abdominal obesity exhibited a positive association with depressive symptoms among Asian overweight adults, particularly in females. Prevention and early diagnosis of depressive symptoms should focus on overweight females.
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  • 文章类型: Journal Article
    背景:肥胖,尤其是腹部肥胖,与代谢和其他健康风险密切相关。肥胖的诊断和评估在临床和常规预防实践中很重要。从风险的角度来看,不仅要区分脂肪组织的堆积区域,也是它的类型。
    目的:本研究的目的是使用一种新型的便携式腹部生物阻抗分析仪,用于腹部脂肪组织区域,作为一组选定志愿者的身体结构评估的一部分,重点是皮下和内脏脂肪组织的分化,并评估其在实践中的有效性。
    方法:使用便携式腹部生物阻抗分析仪Yscope(PA-BIA)结合生物阻抗装置InBody970(高频生物电阻抗/HF-BIA)分析身体成分。83名年龄为24.92±7.24岁的男女志愿者参加了研究。
    结果:性别之间的腹部脂肪没有显着差异,女性达到平均值2.01±1.14公斤,男性2.22±1.60公斤(p>0.05)。性别分化表现在内脏脂肪(p<0.01)和内脏脂肪面积(p<0.01),女性的价值低于男性。在皮下脂肪的情况下,我们发现价值观与性别相反的趋势,在男性获得较低价值的地方,但差异无统计学意义(p>0.05)。内脏脂肪与腹部脂肪(r=0.86)和腰围(r=0.85)的相关性最大,皮下脂肪与腹部脂肪(r=0.93)和体脂质量(r=0.93)的正相关最强。
    结论:PA-BIA结合HF-BIA可以确定腹部皮下和内脏脂肪的代表,传统的MFS-BIA方法不允许。在评估身体成分时,确认了显著的性别差异,这是影响与性别有关的不同健康风险的重要因素,以及在身体不同部位定位和积累的不同类型的脂肪组织的代表性。
    BACKGROUND: Obesity, especially abdominal obesity, is strongly correlated with metabolic and other health risks. Diagnosis and assessment of obesity is important in clinical and routine preventive practice. From the point of view of risk, it is necessary to distinguish not only the area of fat tissue accumulation, but also its type.
    OBJECTIVE: The aim of the study was to use a new portable abdominal bioimpedance analyzer, which is intended for the area of abdominal adipose tissue, as part of the evaluation of the body structure of a selected group of volunteers with a focus on the differentiation of subcutaneous and visceral adipose tissue and to assess its usefulness in practice.
    METHODS: Body composition was analyzed using a portable abdominal bioimpedance analyzer Yscope (PA-BIA) in combination with a bioimpedance device InBody 970 (high-frequency bioelectrical impedance/HF-BIA). Eighty-three volunteers at the age of 24.92±7.24 years with representation of both sexes participated in the study.
    RESULTS: Abdominal fat did not differ significantly between the sexes, women reached an average value of 2.01±1.14 kg, men 2.22±1.60 kg (p>0.05). Gender differentiation was manifested in the case of visceral fat (p<0.01) and visceral fat area (p<0.01), the values of which were lower in women than in men. In the case of subcutaneous fat, we found the opposite trend of values in relation to gender, where lower values were achieved by men, but there were no significant differences (p>0.05). Visceral fat was most correlated with abdominal fat (r=0.86) and waist circumference (r=0.85), subcutaneous fat had the strongest positive correlations with abdominal fat (r=0.93) and with body fat mass (r=0.93).
    CONCLUSIONS: PA-BIA in combination with HF-BIA makes it possible to determine the representation of subcutaneous and visceral fat in the abdominal area, which the conventional MFS-BIA method does not allow. When evaluating body composition, significant gender differentiation is confirmed, which is an important factor affecting different health risks related to gender and the representation of different types of fat tissue localized and accumulated in different parts of the body.
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  • 文章类型: Journal Article
    目的:我们旨在分析1998年至2017年芬兰和瑞典腹主动脉瘤(AAA)的开放(OAR)或腔内修复(EVAR)后的患者预后。完整和破裂的AAAs(rAAAs)均包括在分析中。方法:分析了芬兰和瑞典国家登记处的患者水平数据,完整和破裂AAA修复的配对手术与死亡率数据(死亡日期)。全因死亡率是主要终点。来自这两个国家的匿名患者数据进行汇总,包括总共32,324次操作。破裂和完整的AAAs分别考虑。总的来说,对9619个完整的AAAs和1470个rAAAs进行了EVAR,而OAR是对13,241个完整的AAA和7994个rAAA进行的。病人的年龄,性别和手术日期作为人口统计信息.Cox回归和Kaplan-Meier分析用于评估AAA或rAAA治疗后的长期(10年)生存率。Kaplan-Meier分析在三个不同年龄段(<65岁,65-79岁和≥80岁)。结果:考虑到所有年龄组,1-,EVAR后3年和10年Kaplan-Meier生存率为93.4%,80.5%和35.3%,分别,完整的AAA修复和67.2%,55.9%和22.2%,分别,用于RAAA修复。对于完整AAAs的OAR,1-,3年和10年Kaplan-Meier生存率为92.1%,84.8%和48.7%,分别。rAAAs的OAR率分别为55.4%,49.3%和24.6%。在Cox回归分析中,最近一年的手术与生存率的提高有关,年龄和年龄对完整和破裂的AAA修复的生存率均产生负面影响。如果患者在手术后的前90天存活下来,对于<65岁的患者(一般人群:18.0岁),完整的AAA修复后的生存期为13.5年,≥80岁的人为7.3岁(一般人群:7.9岁)。经过rAAA修复,<65岁患者的平均生存期为13.1年,≥80岁患者的平均生存期为5.5年,分别。结论:80岁或以上接受完整AAA治疗的患者的长期生存率接近普通人群,只要他们在手术中幸存下来。相反,对于年龄小于65岁的患者,其长期生存率明显较差.随着时间的推移,AAA患者的长期生存率有所改善。对于接受完整AAA修复的年轻患者,开放手术仍然是安全有效的选择。我们的结果支持ESVS指南推荐的EVAR作为rAAA患者的一线治疗。
    Objective: We aimed to analyse patient outcomes following open (OAR) or endovascular repair (EVAR) of an abdominal aortic aneurysm (AAA) in Finland and Sweden from 1998 to 2017. Both intact and ruptured AAAs (rAAAs) were included in the analysis. Methods: Patient-level data from national registries in Finland and Sweden were analysed, pairing operations for intact and ruptured AAA repair with mortality data (date of death). All-cause mortality was the primary endpoint. Anonymized patient data from both countries were pooled, comprising a total of 32,324 operations. Ruptured and intact AAAs were considered separately. In total, EVAR was performed on 9619 intact AAAs and 1470 rAAAs, while OAR was performed on 13,241 intact AAAs and 7994 rAAAs. The patient\'s age, sex and the date of operation were obtained as demographic information. Cox regression and Kaplan-Meier analyses were used to evaluate long-term (10-year) survival after the treatment of AAA or rAAA with either modality. Kaplan-Meier analysis was performed in three different age groups (<65 years, 65-79 years and ≥80 years). Results: Considering all age groups together, the 1-, 3- and 10-year Kaplan-Meier survival rates after EVAR were 93.4%, 80.5% and 35.3%, respectively, for intact AAA repair and 67.2%, 55.9% and 22.2%, respectively, for rAAA repair. For OAR of intact AAAs, the 1-, 3- and 10-year Kaplan-Meier survival rates were 92.1%, 84.8% and 48.7%, respectively. The respective rates for OAR of rAAAs were 55.4%, 49.3% and 24.6%. In a Cox regression analysis, a more recent year of operation was associated with improved survival, and older age affected survival negatively for both intact and ruptured AAA repair. If patients survived the first 90 days after the operation, the survival after intact AAA repair was 13.5 years for those <65 years (general population: 18.0 years), and 7.3 years for those ≥80 years (general population: 7.9 years). After rAAA repair, the mean survival was 13.1 years for patients <65 years and 5.5 years for patients ≥80 years, respectively. Conclusions: The long-term survival of patients undergoing intact AAA treatment at the age of 80 or older is close to that of the general population, provided they survive the operation. Conversely, for patients younger than 65, the long-term survival is markedly worse. The long-term survival of AAA patients has improved over time. Open surgery is still a safe and effective option for young patients undergoing intact AAA repair. Our results support the ESVS guidelines recommendation of EVAR being the first-line treatment for patients with rAAA.
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  • 文章类型: Journal Article
    背景:患有不同阶段的结直肠癌(CRC)的患者表现出不同的腹部计算机断层扫描(CT)征象。因此,必须确定CT征象对CRC预后的影响。
    目的:观察结直肠癌患者腹部CT征象,分析CT征象与术后预后的相关性。
    方法:回顾性分析南方医科大学顺德医院附属杏坛医院行根治性手术的88例CRC患者的病史和CT影像学检查结果。采用单因素和多因素Cox回归分析探讨CRC患者术后死亡的独立危险因素。3年生存率采用Kaplan-Meier曲线分析,并采用Spearman相关分析法分析CRC患者术后生存时间与腹部CT征象的相关性。
    结果:对于CRC患者,3年生存率为73.86%。死亡组比生存组表现出更严重的特征。多因素Cox回归模型分析显示,体重指数(BMI),肠周浸润程度,肿瘤大小,淋巴结CT值是影响术后死亡的独立因素(均P<0.05)。具有典型特征的死亡组患者的三年生存率较低(log-rankχ2分别为66.487、11.346、12.500和27.672,全部P<0.05)。结直肠癌患者的生存时间与BMI呈负相关,肠周浸润程度,肿瘤大小,淋巴结CT值,平均肿瘤长轴直径,和平均肿瘤短轴直径(r分别为-0.559、0.679、-0.430、-0.585、-0.425和-0.385,全部P<0.05)。BMI与肠周浸润程度呈正相关,淋巴结CT值,和平均肿瘤短轴直径(r分别为0.303、0.431和0.437,全部P<0.05)。
    结论:肠周浸润程度,肿瘤大小,淋巴结CT值对评估CRC患者的预后至关重要。
    BACKGROUND: Patients with different stages of colorectal cancer (CRC) exhibit different abdominal computed tomography (CT) signs. Therefore, the influence of CT signs on CRC prognosis must be determined.
    OBJECTIVE: To observe abdominal CT signs in patients with CRC and analyze the correlation between the CT signs and postoperative prognosis.
    METHODS: The clinical history and CT imaging results of 88 patients with CRC who underwent radical surgery at Xingtan Hospital Affiliated to Shunde Hospital of Southern Medical University were retrospectively analyzed. Univariate and multivariate Cox regression analyses were used to explore the independent risk factors for postoperative death in patients with CRC. The three-year survival rate was analyzed using the Kaplan-Meier curve, and the correlation between postoperative survival time and abdominal CT signs in patients with CRC was analyzed using Spearman correlation analysis.
    RESULTS: For patients with CRC, the three-year survival rate was 73.86%. The death group exhibited more severe characteristics than the survival group. A multivariate Cox regression model analysis showed that body mass index (BMI), degree of periintestinal infiltration, tumor size, and lymph node CT value were independent factors influencing postoperative death (P < 0.05 for all). Patients with characteristics typical to the death group had a low three-year survival rate (log-rank χ 2 = 66.487, 11.346, 12.500, and 27.672, respectively, P < 0.05 for all). The survival time of CRC patients was negatively correlated with BMI, degree of periintestinal infiltration, tumor size, lymph node CT value, mean tumor long-axis diameter, and mean tumor short-axis diameter (r = -0.559, 0.679, -0.430, -0.585, -0.425, and -0.385, respectively, P < 0.05 for all). BMI was positively correlated with the degree of periintestinal invasion, lymph node CT value, and mean tumor short-axis diameter (r = 0.303, 0.431, and 0.437, respectively, P < 0.05 for all).
    CONCLUSIONS: The degree of periintestinal infiltration, tumor size, and lymph node CT value are crucial for evaluating the prognosis of patients with CRC.
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  • 文章类型: Journal Article
    背景:本研究旨在探讨通过经皮腹腔脓肿引流程序获得的微生物诊断诊断结果的影响因素。我们分析了不同临床,放射学,以及在这种情况下微生物诊断成功的术前因素。
    方法:对经皮腹腔脓肿引流术患者进行回顾性分析,以评估影响微生物诊断诊断率的因素。
    结果:共174例接受经皮腹腔脓肿引流的患者。在手术过程中使用抗生素和脓肿扩散到其他器官显着增加了获得阳性培养物的可能性。具体来说,在手术过程中使用抗生素会使风险增加3.30倍(OR=3.30,95%CI1.48-7.65,p=0.004),而脓肿扩散到另一个器官的风险增加了约1.87倍(OR=1.87,95%CI0.98-3.61,p=0.057)。此外,在培养结果为阳性的患者中,含有空气的脓肿和具有空气-液体水平的脓肿更为常见。其他因素,比如性别,年龄,恶性肿瘤患病率,手术史,没有显著影响培养结果。
    结论:这项研究提供了对影响经皮腹腔脓肿引流微生物诊断诊断率的因素的有价值的见解。研究结果强调了在计划和执行脓肿引流程序时考虑患者特定变量和程序方面的重要性。进一步的研究可以基于这些见解来制定基于证据的指南,以优化经皮腹部脓肿引流程序的诊断率。
    BACKGROUND: This study aimed to investigate the factors influencing the diagnostic yield of microbiologic diagnosis obtained through percutaneous abdominal abscess drainage procedures. We analyzed the influence of diverse clinical, radiological, and pre-procedural factors on the success of microbiologic diagnosis in this context.
    METHODS: A retrospective analysis of patients who underwent percutaneous abdominal abscess drainage was performed to assess the factors affecting the diagnostic yield for microbiologic diagnosis.
    RESULTS: A total of 174 patients undergoing percutaneous abdominal abscess drainage was included. The use of antibiotics during the procedure and the spread of the abscess to other organs significantly increased the likelihood of obtaining a positive culture. Specifically, antibiotic use during the procedure raised the risk by up to 3.30-fold (OR = 3.30, 95% CI 1.48-7.65, p = 0.004), while abscess spread to another organ increased the risk by approximately 1.87-fold (OR = 1.87, 95% CI 0.98-3.61, p = 0.057). Additionally, abscesses containing air and abscesses with an air-fluid level were more common in patients with positive culture results. Other factors, such as gender, age, malignancy prevalence, and surgical history, did not significantly impact culture results.
    CONCLUSIONS: This study provides valuable insights into the factors affecting the diagnostic yield of microbiologic diagnosis from percutaneous abdominal abscess drainage. The findings underscore the importance of considering patient-specific variables and procedural aspects when planning and executing abscess drainage procedures. Further research can build upon these insights to develop evidence-based guidelines for optimizing the diagnostic yield of percutaneous abdominal abscess drainage procedures.
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  • 文章类型: Journal Article
    背景:人工智能已越来越多地用于医学成像,并在图像分类任务中表现出专家级的性能。
    目的:开发一种使用腹部X光片深度学习确定Risser分期的全自动方法。
    方法:在这项多中心研究中,1,681仰卧腹部X光片(年龄范围,9-18岁,2019年1月至2022年4月之间获得的50%女性)从三个医疗机构进行回顾性收集,并使用美国Risser分期系统进行手动分级。共有来自医院1和2的1,577张图像用于开发,和104张来自医院3的图像进行外部验证。从每张射线照片来看,使用骨盆骨分割模型DeepLabv3+和EfficientNet-B0编码器,利用90张数字化重建的X线照片,利用骨盆骨面罩进行骨盆计算机断层扫描,提取右和左髂脊斑块图像.使用这些补丁图像,ConvNeXt-B被训练为根据Risser分类进行分级。使用准确性评估了模型的性能,接收器工作特性曲线下面积(AUROC),和平均绝对误差。
    结果:全自动Risser阶段评估模型在内部和外部测试集上显示出0.87和0.75的准确性,0.13和0.26的平均绝对误差以及0.99和0.95的AUROC,分别。
    结论:我们开发了基于深度学习的,使用腹部X光片进行Risser分期评估的全自动分割和分类模型。
    BACKGROUND: Artificial intelligence has been increasingly used in medical imaging and has demonstrated expert level performance in image classification tasks.
    OBJECTIVE: To develop a fully automatic approach for determining the Risser stage using deep learning on abdominal radiographs.
    METHODS: In this multicenter study, 1,681 supine abdominal radiographs (age range, 9-18 years, 50% female) obtained between January 2019 and April 2022 were collected retrospectively from three medical institutions and graded manually using the United States Risser staging system. A total of 1,577 images from Hospitals 1 and 2 were used for development, and 104 images from Hospital 3 for external validation. From each radiograph, right and left iliac crest patch images were extracted using the pelvic bone segmentation model DeepLabv3 + with the EfficientNet-B0 encoder trained with 90 digitally reconstructed radiographs from pelvic computed tomography scans with a pelvic bone mask. Using these patch images, ConvNeXt-B was trained to grade according to the Risser classification. The model\'s performance was evaluated using accuracy, area under the receiver operating characteristic curve (AUROC), and mean absolute error.
    RESULTS: The fully automatic Risser stage assessment model showed an accuracy of 0.87 and 0.75, mean absolute error of 0.13 and 0.26, and AUROC of 0.99 and 0.95 on internal and external test sets, respectively.
    CONCLUSIONS: We developed a deep learning-based, fully automatic segmentation and classification model for Risser stage assessment using abdominal radiographs.
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  • 文章类型: Journal Article
    目的:腹主动脉瘤(AAA)的生长仍是一个尚未完全了解的过程。这项研究的目的是分析墨西哥队列中与AAA直径变化相关的危险因素。
    方法:一项观察性研究,我们分析了2014年至2021年在计算机断层扫描(CT)研究中报告AAA并进行了随访CT的患者的全部情况。我们根据2型糖尿病的诊断和药理学史(糖尿病与非糖尿病,二甲双胍与非二甲双胍摄入量和他汀类药物与非他汀类药物摄入量)。我们使用配对t检验比较了随访前后的AAA直径。进行多变量分析以鉴定与增加的生长速率相关的独立变量。对Stata17进行统计分析。
    结果:在研究期间,72例(39.77%)患者进行了CT随访。平均年龄为75岁(±9.05),男性为52岁(72.22%)。当根据二甲双胍摄入量比较肾下最大直径时,仅在二甲双胍非摄入组中发现显着差异(42.05±12.54vs45.34±12.06[P=0.02]),相反,通过随访,二甲双胍摄入组的测量值无明显差异(36.13±7.04vs37.00±4.51;P=0.57)。在多变量分析中,诊断时AAA最大直径与生长速率显着增加相关(coeff=0.06,P<0.05)。
    结论:AAA直径在不同的流行病学和临床因素的影响下呈非线性随时间变化。在我们研究的人群中,二甲双胍的摄入似乎促进了AAA直径增长的稳定性。
    OBJECTIVE: Abdominal Aortic Aneurysms (AAA) growth remains a process not fully understood. The objective of this study was to analyze risk factors associated with changes in AAA diameter in a Mexican cohort.
    METHODS: An observational study in which we analyzed the entirely of patients in which an AAA was reported in a Computed Tomography (CT) study from 2014 to 2021 who had a follow-up CT. We divided them by groups depending on the diagnosis of type 2 diabetic mellitus and pharmacological history (diabetic vs non-diabetic, metformin vs non-metformin intake and statin vs non-statin intake). We compared pre and post follow-up AAA diameters using paired t-tests. A multivariate analysis was performed in order to identify independent variables associated with an increased growth rate. Statistical analysis was performed on Stata 17.
    RESULTS: During the studied period 72 (39.77%) patients had a follow-up CT. Mean age was 75 years (±9.05) and 52 (72.22%) were men. When comparing infra-renal largest diameter through time based on metformin intake, a significant difference was found only in the metformin non-intake group (42.05 ± 12.54 vs45.34 ± 12.06 [P = 0.02]), in contrast the metformin intake group measures were non-significantly different (36.13 ± 7.04 vs 37.00 ± 4.51; P = 0.57) through follow-up. In the multivariate analysis AAA largest diameter at diagnosis correlated with significantly increased growth rate (coeff = 0.06, P < 0.05).
    CONCLUSIONS: AAA diameters appear to change through time in a non-linear pattern influenced by different epidemiological and clinical factors. Metformin intake appears to promote a stability in AAA diameter growth in our studied population.
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  • 文章类型: Journal Article
    我们回顾了婴儿和儿童肠梗阻的病因,可以通过超声(US)识别,包括穿孔性阑尾炎。肠套叠,异物摄入,结肠扭转,腹内肿块病变,内疝,和狭窄的炎症性肠病。美国有可能确定这些年龄组肠梗阻的原因,不需要额外的横截面成像,并且可以帮助患者管理,包括介入和手术计划。因此,熟悉婴儿和儿童肠梗阻的超声影像学表现很重要。
    We review the etiologies of bowel obstruction in infants and children that can be identified on ultrasound (US) including perforated appendicitis, intussusception, foreign body ingestion, colonic volvulus, intra-abdominal mass lesions, internal hernia, and stricturing inflammatory bowel disease. US can potentially identify the cause of bowel obstruction in these age groups, without the need for additional cross-sectional imaging, and can aid in patient management including interventional and surgical planning. Hence, it is important to be familiar with the sonographic imaging findings of bowel obstruction in infants and children.
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  • 文章类型: Journal Article
    在没有严重肝功能障碍的肠衰竭(IF)的情况下,需要进行孤立的肠移植(IT)。短肠综合征(SBS)是最常见的IF病因,并且由于这些患者的腹腔中缺乏或大量减少了肠环,腹壁有萎缩和肌肉收缩,导致腹部区域和弹性的丧失,并阻止腹壁的初次闭合。这项研究旨在描述一种在不使用假体的情况下闭合IT后腹壁的技术。
    4例患者接受了IT治疗,不可能直接关闭腹壁。我们描述了一种新颖的技术,联合一系列真空辅助闭合敷料,组件分离,和放松切口。
    所有患者均采用上述技术成功闭合腹壁,无腹壁相关并发症。
    该技术被证明是安全的,有效,并且可重复作为IT后腹壁闭合的一种选择。在更多的情况下采用这种技术对于确认这些结果是必要的。
    UNASSIGNED: Isolated intestinal transplantation (IT) is indicated in cases of intestinal failure (IF) in the absence of severe liver dysfunction. Short bowel syndrome (SBS) is the most frequent IF etiology, and due to the absence or considerable reduction of intestinal loops in the abdominal cavity in these patients, there is atrophy and muscle retraction of the abdominal wall, leading to loss of the abdominal domain and elasticity and preventing the primary closure of the abdominal wall. This study aimed to describe a technique for the closure of the abdominal wall after IT without using prostheses.
    UNASSIGNED: Four patients underwent IT with the impossibility of primary closure of the abdominal wall. We describe a novel technique, associating a series of vacuum-assisted closure dressings, components separation, and relaxation incisions.
    UNASSIGNED: All patients presented a successful closure of the abdominal wall with the described technique, with no complications related to the abdominal wall.
    UNASSIGNED: The technique proved to be safe, effective, and reproducible as an option for abdominal wall closure after IT. Employing this technique in a greater number of cases is necessary to confirm these results.
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  • 文章类型: Journal Article
    肥胖与败血症之间的关系越来越受到关注。本研究旨在探讨生命过程肥胖与脓毒症发病率之间的因果关系。
    本研究采用孟德尔随机化(MR)方法。仪器变体是从全基因组关联研究中获得的,用于生命周期肥胖,包括出生体重,儿童体重指数(BMI),儿童肥胖,成人BMI,腰围,内脏肥胖,和身体脂肪百分比。本研究使用了包括10,154例和454,764例对照在内的脓毒症全基因组关联研究的荟萃分析。MR分析使用逆方差加权,MREgger回归,加权中位数,加权模式,和简单的模式。仪器变量在全基因组显著性水平上被鉴定为显著的单核苷酸多态性(P<5×10-8)。进行敏感性分析以评估MR估计的可靠性。
    使用逆方差加权方法的MR分析显示,儿童BMI增加的遗传易感性(OR=1.29,P=0.003),儿童肥胖(OR=1.07,P=0.034),成人BMI(OR=1.38,P<0.001),成人腰围(OR=1.01,P=0.028),成人内脏肥胖(OR=1.53,P<0.001)预测脓毒症的风险较高。敏感性分析未发现MR结果有任何偏倚。
    结果表明,儿童和成人的肥胖对败血症的发病率有因果关系。然而,仍需要更多精心设计的研究来验证它们之间的关联.
    UNASSIGNED: The relationship between adiposity and sepsis has received increasing attention. This study aims to explore the causal relationship between life course adiposity and the sepsis incidence.
    UNASSIGNED: Mendelian randomization (MR) method was employed in this study. Instrumental variants were obtained from genome-wide association studies for life course adiposity, including birth weight, childhood body mass index (BMI), childhood obesity, adult BMI, waist circumference, visceral adiposity, and body fat percentage. A meta-analysis of genome-wide association studies for sepsis including 10,154 cases and 454,764 controls was used in this study. MR analyses were performed using inverse variance weighted, MR Egger regression, weighted median, weighted mode, and simple mode. Instrumental variables were identified as significant single nucleotide polymorphisms at the genome-wide significance level (P < 5×10-8). The sensitivity analysis was conducted to assess the reliability of the MR estimates.
    UNASSIGNED: Analysis using the MR analysis of inverse variance weighted method revealed that genetic predisposition to increased childhood BMI (OR = 1.29, P = 0.003), childhood obesity (OR = 1.07, P = 0.034), adult BMI (OR = 1.38, P < 0.001), adult waist circumference (OR = 1.01, P = 0.028), and adult visceral adiposity (OR = 1.53, P < 0.001) predicted a higher risk of sepsis. Sensitivity analysis did not identify any bias in the MR results.
    UNASSIGNED: The results demonstrated that adiposity in childhood and adults had causal effects on sepsis incidence. However, more well-designed studies are still needed to validate their association.
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