UNASSIGNED:在美国眼科学会的IRIS®注册(IntelligentResearchinSight)报告巩膜炎患者的患者特征和与视力差和眼内压(IOP)异常相关的因素。
未经评估:回顾性队列研究。
UNASSIGNED:从2013年到2019年,IRIS登记处的患者至少有3次与国际疾病分类相关的诊所就诊。
UASSIGNED:我们评估了巩膜炎和巩膜炎亚型队列的人口统计学和临床特征。我们进行了Cox比例风险和多元逻辑回归分析,以评估与不良最佳矫正视力(BCVA)的关联。视力丧失,和IOP异常。
未经评估:患者特征,最小分辨率角(logMAR)的0.6对数的BCVA或更大,BCVA在演示后6个月恶化超过3个logMAR单位,IOP为30mmHg或更高,眼压为5mmHg或更低。
未经证实:在111314例巩膜炎患者的队列中,平均±标准差年龄为58.5±16.6岁,66%是女性,30%患有双侧巩膜炎。穿孔性巩膜软化患者年龄较大,更可能患有双侧疾病。多元逻辑回归分析确定了表现不良BCVA的几率增加的因素(年龄较大,男性,黑人种族,西班牙裔种族,吸烟,和巩膜炎亚型)以及初次诊断巩膜炎6个月后至少3行视力丧失(年龄较大,吸烟,和前巩膜炎)。0.6logMAR或更高的BCVA的Cox比例风险回归模型显示年龄较大(每10年单位调整的风险比[aHR],1.11),黑人种族(AHR,1.19),西班牙裔种族(AHR,1.22),主动吸烟(AHR,1.39),以前吸烟(AHR,1.26),某些巩膜炎亚型会增加视力发育不良的风险(全部P<0.001)。年纪大了,男性,黑人种族,西班牙裔种族,吸烟,巩膜炎亚型增加了IOP异常的几率。
未经批准:年龄较大,黑人或西班牙血统,吸烟,在IRIS注册中,特定的巩膜炎亚型是巩膜炎患者视力和IOP转归较差的危险因素.更密切的随访可能适合老年人,黑色,或西班牙裔巩膜炎患者;吸烟者应接受戒烟援助。
UNASSIGNED: To report patient characteristics and factors associated with poor visual acuity and abnormal intraocular pressure (IOP) in patients with scleritis in the American Academy of Ophthalmology\'s IRIS® Registry (Intelligent Research in Sight).
UNASSIGNED: Retrospective cohort study.
UNASSIGNED: Patients in the IRIS Registry with at least 3 office visits associated with an International Classification of Diseases scleritis code from 2013 through 2019.
UNASSIGNED: We evaluated demographic and clinical characteristics in scleritis and scleritis subtype cohorts. We conducted Cox proportional hazards and multiple logistic regression analyses to assess associations with poor best-corrected visual acuity (BCVA), vision loss, and IOP abnormalities.
UNASSIGNED: Patient characteristics, BCVA of 0.6 logarithm of the minimum angle of resolution (logMAR) or more, BCVA worsened by more than 3 logMAR units 6 months after presentation, IOP of 30 mmHg or more, and IOP of 5 mmHg or less.
UNASSIGNED: In this cohort of 111 314 patients with scleritis, the mean ± standard deviation age was 58.5 ± 16.6 years, 66% were women, and 30% had bilateral scleritis. Patients with scleromalacia perforans were older and more likely to have bilateral disease. Multiple logistic regression analysis identified factors with increased odds for poor presenting BCVA (older age, male sex, Black race, Hispanic ethnicity, smoking, and scleritis subtypes) and at least 3 lines of vision loss 6 months after initial scleritis diagnosis (older age, smoking, and anterior scleritis). Cox proportional hazards regression modeling of BCVA of 0.6 logMAR or more showed older age (adjusted hazard ratio [aHR] per 10-year unit, 1.11), Black race (aHR, 1.19), Hispanic ethnicity (aHR, 1.22), active smoking (aHR, 1.39), former smoking (aHR, 1.26), and certain scleritis subtypes increase the risk of poor visual acuity development (P < 0.001 for all). Older age, male sex, Black race, Hispanic ethnicity, smoking, and scleritis subtypes increased the odds of IOP abnormality.
UNASSIGNED: Older age, Black or Hispanic ancestry, smoking, and specific scleritis subtypes are risk factors for worse visual and IOP outcomes in patients with scleritis in the IRIS Registry. Closer follow-up may be appropriate for older, Black, or Hispanic patients with scleritis; smokers should receive smoking cessation assistance.