尽管外观统一,小脑皮层在结构上高度异质，遗传学和生理学。浦肯野细胞（PC），小脑皮层的主要和唯一的输出神经元，可以分为差异表达分子标记并显示独特生理特征的多个群体。这些特征包括动作电位率，还有它们对突触和内在可塑性的倾向。然而,与PC的不同生理特性相关的精确分子和遗传因素仍然难以捉摸。在这篇文章中,我们提供了调节PC活性和可塑性的细胞机制的详细概述。我们进一步进行了通路分析，以强调特定PC群体的分子特征如何影响其生理和可塑性机制。
Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.
