为了治愈一系列疾病,科学家已经研究了许多由天然来源产生的生物活性抗氧化剂化合物。芒果苷,C-糖基黄原酮结构的黄色多酚,芒果和其他食物来源丰富。深入检查发现,由于其抗病毒作用,它可有效治疗各种疾病,抗炎,抗增殖,抗基因毒性,抗动脉粥样硬化,辐射防护,肾保护,抗高脂血症,和抗糖尿病特性。然而,人们认识到芒果苷的生物利用度很低,波动性,和有限的溶解度限制了它的治疗用途。随着时间的推移,这些问题的有效解决方案已经以有效的递送方法的形式出现。当前的文章总结了几项更新芒果苷生物制药特性的研究。此外,提高生物利用度的策略,稳定性,并对该植物药的溶解性进行了讨论。这篇综述提供了有关创新的芒果苷递送方法的详细信息,例如纳米颗粒,脂质体,胶束,Niosomes,微球,金属纳米颗粒,和络合,以及其在各个领域的治疗应用。本文为希望致力于制定和开发有效的递送方法以提高Magniferin治疗效果的研究人员提供了有效的指导。
In order to cure a range of ailments, scientists have investigated a number of bioactive antioxidant compounds produced from natural sources. Mangiferin, a C-glycosyl
xanthone-structured yellow polyphenol, is abundant in mangoes and other dietary sources. In-depth examinations found that it is effective in the treatment of a variety of disorders due to its antiviral, anti-inflammatory, antiproliferative, antigenotoxic, antiatherogenic, radioprotective, nephroprotective, antihyperlipidemic, and antidiabetic properties. However, it is recognised that mangiferin\'s poor bioavailability, volatility, and limited solubility restrict its therapeutic usefulness. Over time, effective solutions to these problems have arisen in the shape of effective delivery methods. The current articles present a summary of the several researches that have updated Mangiferin\'s biopharmaceutical characteristics. Additionally, strategies for enhancing the bioavailability, stability, and solubility of this phytodrug have been discussed. This review provides detailed information on the development of innovative Mangiferin delivery methods such as nanoparticles, liposomes, micelles, niosomes, microspheres, metal nanoparticles, and complexation, as well as its therapeutic applications in a variety of sectors. This article provides effective guidance for researchers who desire to work on the formulation and development of an effective delivery method for improved magniferin therapeutic effectiveness.