目的:单核苷酸多态性(SNP)在基因中很常见,可导致组织中基因表达失调,会影响致癌作用。许多研究报告了色素性干皮病D组(XPD)rs13181和rs1799793多态性与口腔癌风险之间的关联。但结果相互矛盾和不确定。
方法:我们通过PubMed进行了全面而系统的搜索,Elsevier,WebofScience,和Embase数据库,在荟萃分析中纳入了12项研究,以确定XPDrs13181和rs1799793多态性是否与口腔癌风险相关.
结果:汇总日期表明rs13181多态性与等位基因比较模型的口腔癌风险之间存在显着关联(优势比,OR=1.60,95%置信区间,CI=1.09-2.35,P=0.02),显性模型(OR=1.74,95%CI=1.08-2.82,P=0.02),和杂合子模型(OR=1.59,95%CI=1.02-2.49,P=0.04)。对于XPDrs1799793多态性,在任何模式下,它都与口腔癌的发病率无关。基于种族的亚组分析表明,根据等位基因比较模型,rs13181多态性增加了亚洲人口腔癌的风险(OR=1.97,95%CI=1.10-3.51,P=0.02),显性模型(OR=2.35,95%CI=1.25-4.44,P=0.008),杂合子模型(OR=2.05,95%CI=1.15-3.66,P=0.01),纯合模型(OR=2.47,95%CI=1.06~5.76,P=0.04)。
结论:我们的荟萃分析表明XPDrs13181多态性与亚洲人口腔癌的发展呈正相关,但白种人人群之间呈负相关。
OBJECTIVE: Single nucleotide polymorphisms (SNPs) are common in genes and can lead to dysregulation of gene expression in tissues, which can affect carcinogenesis. Many studies reporting the association between xeroderma pigmentosum group D (
XPD) polymorphisms of rs13181 and rs1799793 with oral cancer risk, but with conflicting and inconclusive results.
METHODS: We performed a comprehensive and systematic search through the PubMed, Elsevier, Web of science, and Embase databases, twelve studies were included in the meta-analysis to determine whether
XPD rs13181 and rs1799793 polymorphism contributed to the risk of oral cancer.
RESULTS: The pooled date indicated a significant association between the rs13181 polymorphism and oral cancer risk for the allele comparison model (odds ratio, OR = 1.60, 95% confidence intervals, CI = 1.09-2.35, P = 0.02), the dominant model (OR = 1.74, 95% CI = 1.08-2.82, P = 0.02), and the heterozygote model (OR = 1.59, 95% CI = 1.02-2.49, P = 0.04). For the
XPD rs1799793 polymorphism, it is not associated with the incidence of oral cancer under any model. Subgroup analyses based on ethnicity indicated that the rs13181 polymorphism increased the risk of oral cancer among Asians according to the allele comparison model (OR = 1.97, 95% CI = 1.10-3.51, P = 0.02), the dominant model (OR = 2.35, 95% CI = 1.25-4.44, P = 0.008), the heterozygote model (OR = 2.05, 95% CI = 1.15-3.66, P = 0.01), and the homozygous model (OR = 2.47, 95% CI = 1.06-5.76, P = 0.04).
CONCLUSIONS: Our meta-analysis suggests a positive correlation between
XPD rs13181polymorphism and the development of oral cancer among Asians, but a negative correlation among Caucasians populations.