Wrist surgery

手腕手术
  • 文章类型: Journal Article
    肩胛骨(SL)骨间韧带(SLIL)的损伤是腕骨不稳定的常见原因。内部支具增强已用于各种韧带修复程序;然而,需要进一步研究其在手外科中的结局.这项研究旨在检查接受SLIL修复并内部支架增强的患者的预后。
    联系了使用内部支撑技术进行SLIL修复且随访至少1年的患者。可用的患者返回以进行新的X射线照片和体格检查。如果无法联系患者,但在手术后1年以上进行了X射线和身体检查,这些数据是从他们的医疗记录中收集的。参与的患者完成了QuickDASH和患者额定腕部评估调查,并评估了他们对手术的满意度。评估的结果包括手腕的活动范围,握力,舟骨移位试验,SL间隙,SL角度,和桡骨关节炎的影像学证据。
    我们收集了13例患者(12例男性)的14例SLIL修复结果。平均随访时间为41个月(n=14,17-64)。平均QuickDASH和患者额定腕部评估得分分别为6.1(0-43.2)和9.6(0-65),分别。从即时到最新的随访,射线照相测量保持稳定,并且没有注意到放射性腕骨关节炎的变化。然而,SL间隙从术前的平均5.33mm(3.4-6.7)减少到最新随访的3.34mm(2-4.6),SL角从手术前的平均79.5°(67°-97°)下降到最新随访的67.3°(51°-85°)。所有舟骨移位测试均稳定。
    因此,SL内部支架增强具有良好的短期效果,改善疼痛,函数,满意,术后大于1年的腕部对齐。这种技术可以是在短期内管理SL不稳定性的有效选择。
    治疗IV。
    UNASSIGNED: Injury to the scapholunate (SL) interosseous ligament (SLIL) is a common cause of carpal instability. Internal brace augmentation has been used in various ligament repair procedures; however, further investigation of its outcomes in hand surgery is needed. This study aimed to examine outcomes for patients who underwent SLIL repair with internal brace augmentation.
    UNASSIGNED: Patients who underwent SLIL repair with the internal brace technique and had at least 1 year of follow-up were contacted. Available patients returned for an in-person evaluation with new radiographs and physical examination. If patients could not be contacted but had x-rays and physical examinations performed at greater than 1 year after surgery, these data were collected from their medical records. Participating patients completed the QuickDASH and Patient-Rated Wrist Evaluation surveys and rated their satisfaction with the surgery. Outcomes assessed included wrist range of motion, grip strength, scaphoid shift test, SL gap, SL angle, and radiographic evidence of radiocarpal arthritis.
    UNASSIGNED: We collected outcomes for 14 SLIL repairs among 13 patients (12 male). Mean length of the follow-up was 41 months (n = 14, 17-64). Mean QuickDASH and Patient-Rated Wrist Evaluation scores were 6.1 (0-43.2) and 9.6 (0-65), respectively. Radiographic measurements remained stable from immediate to latest follow-up, and no radiocarpal arthritic changes were noted. However, SL gap decreased from a mean of 5.33 mm (3.4-6.7) before surgery to 3.34 mm (2-4.6) at the latest follow-up, and SL angle decreased from a mean of 79.5° (67°-97°) before surgery to 67.3° (51°-85°) at the latest follow-up. All scaphoid shift tests were stable.
    UNASSIGNED: Therefore, SL internal brace augmentation has favorable short-term results with improvements in pain, function, satisfaction, and carpal alignment at greater than 1 year postoperatively. This technique can be an effective option for the management of SL instability in the short term.
    UNASSIGNED: Therapeutic IV.
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  • 文章类型: Journal Article
    成人腕骨的各种病理导致可以考虑甚至推荐切除的临床情况。在适当的患者群体中,孤立的腕骨切除可以减轻疼痛并改善活动能力。盘形切除术,梯形,梯形和梯形有丰富的文献证据支持积极的长期功能结果。相比之下,孤立地切除头状,Hamate,和三角纹在继发于腕骨力学受损并导致复发性疼痛的文献中的支持有限。此外,孤立的舟骨和月骨切除最好避免继发于腕骨塌陷,并且应与腕骨的稳定手术同时进行。这篇文章提供了一个全面的文献综述,孤立的切除各骨腕骨,他们的适应症,和以前评估的结果。
    Various pathologies of the adult carpus result in clinical scenarios where excision can be considered and even recommended. In the appropriate patient population, isolated carpal excision can alleviate pain and improve mobility. Excisions of the pisiform, trapezium, and trapezoid have abundant literature evidence to support positive long-term functional outcomes. In contrast, isolated excision of the capitate, hamate, and triquetrum has limited support in the literature secondary to compromise of carpal mechanics and lead to recurrent pain. Additionally, isolated scaphoid and lunate excision are best avoided secondary to carpal collapse and should be paired with concomitant stabilizing procedures in the carpus. This article provides a comprehensive literature review of isolated excision of each osseous carpal bone, their indications, and previously assessed outcomes.
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  • 文章类型: Journal Article
    本研究调查了受伤后24小时后治疗的桡骨远端开放性骨折(ODRF)与24小时内治疗相比,是否感染或总体并发症风险增加。
    在一个大型学术机构中对所有接受ODRF治疗的患者进行了6年的回顾性审查。术后并发症包括手术部位感染,需要修正灌溉和清创,软组织愈合延迟,减少的损失,骨不连,和马兰恩。
    120名患者接受了ODRF治疗。受伤时的平均(SD)年龄为59.92(17.68)岁。20例(16.7%)患者发生术后并发症。关于损伤的机制,78(65.0%)具有低能量损伤,42(35.0%)具有高能量损伤。年龄和骨折等级不是重要因素。平均(SD)开放性伤口大小为1.18(1.57)cm。从损伤出现到急诊科(ED)和首次静脉注射抗生素的平均(SD)时间为3.07(4.05)小时,从出现到ED和手术治疗的平均(SD)时间为11.90(6.59)小时,与术后并发症没有显着关联。24例患者(20.0%)在就诊后24小时内接受治疗,这与24小时内治疗的患者没有显着差异。
    24小时后接受ODRF治疗的患者与术后并发症的更大风险无关。因素包括年龄,能量和损伤机制,和骨折等级没有以任何统计学意义的方式改变结局。
    四级。
    UNASSIGNED: This study investigates whether open distal radius fractures (ODRFs) treated after 24 hours from time of injury have an increased risk of infection or overall complication profile compared with those treated within 24 hours.
    UNASSIGNED: Retrospective review was performed of all patients treated for ODRF over a 6-year period at a single large academic institution. Postoperative complications included surgical site infections, need for revision irrigation and debridement, delayed soft tissue healing, loss of reduction, nonunion, and malunion.
    UNASSIGNED: One-hundred twenty patients were treated for ODRF. Mean (SD) age at time of injury was 59.92 (17.68) years. Twenty patients (16.7%) had postoperative complications. Regarding mechanism of injury, 78 (65.0%) had a low-energy and 42 (35.0%) had a high-energy injury. Age and fracture grade were not significant factors. Mean (SD) open wound size was 1.18 (1.57) cm. Mean (SD) time from injury presentation to the emergency department (ED) and first dose of intravenous antibiotics was 3.07 (4.05) hours and mean (SD) time from presentation to the ED and operative treatment was 11.90 (6.59) hours, which did not show a significant association with postoperative complications. Twenty-four patients (20.0%) were treated greater than 24 hours after presentation to the ED, which was not significantly distinct from those treated within 24 hours.
    UNASSIGNED: Patients with ODRFs treated after 24 hours were not associated with a greater risk of postoperative complications. Factors including age, energy and mechanism of injury, and fracture grade did not alter outcome in any statistically significant manner.
    UNASSIGNED: Level IV.
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  • 文章类型: Journal Article
    腕骨的治疗主要是保守的。通过楔形切除骨突进行手术治疗,是可能的。然而,人们普遍认为,由于高复发率,不应对腕骨进行手术。此外,对楔形切除术的临床结局和首选的术后治疗知之甚少.包括保守治疗后接受楔形切除术的腕骨和持续疼痛的患者。他们在手术前和手术后三个月接受了调查问卷。主要结果是使用患者报告的腕部评估(PRWE)测量的疼痛和手功能。其次,复发,对患者满意度和恢复工作时间进行了评估.这些临床结果也在术后接受石膏夹板或压力敷料的患者之间进行了比较。包括76例患者。手术三个月后,看到了PRWE的显着改善,疼痛和功能。观察到复发性腕骨的再手术率为13%。三个月后,58%的患者感到满意,73%的患者重返工作岗位。虽然没有发现临床结果的差异,术后接受压力敷料的患者比接受石膏夹板的患者更满意。目前的研究表明,楔形切除术后的早期结果令人鼓舞,和低复发再手术率。此外,与石膏夹板相比,术后压力敷料似乎更可取。
    The treatment of carpal boss is primarily conservative. Surgical treatment by performing a wedge excision of the bony protrusion, is possible. However, a common belief exists that carpal boss should not be operated because of the high recurrence rate. Additionally, little is known about the clinical outcomes of wedge excision and the preferred post-operative treatment. Patients with carpal boss and persisting pain who underwent wedge excision after conservative treatment were included. They received questionnaires before and three months after surgery. The primary outcomes were pain and hand function measured using patient-reported wrist evaluations (PRWE). Secondarily, recurrence, patient satisfaction and time until return to work were evaluated. These clinical outcomes were also compared between patients who received a plaster splint or a pressure dressing post-operatively. 76 patients were included. Three months after surgery, a significant improvement in PRWE was seen, for both pain and function. A re-operation rate for recurrent carpal boss of 13% was observed. After three months, 58% of patients were satisfied and 73% had returned to work. While no differences in clinical outcomes were found, patients were more satisfied after receiving a pressure dressing than a plaster splint post-operatively. The current study demonstrates encouraging early outcomes after wedge excision, and a low recurrence re-operation rate. Furthermore, a pressure dressing seems preferable post-operatively compared to a plaster splint.
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  • 文章类型: Journal Article
    腕关节镜检查是治疗三角纤维软骨复合体(TFCC)损伤的一种有价值且广泛使用的工具。这些手术包括单纯的滑膜切除术,包膜周围或透骨修复,和关节镜辅助重建,每个都与特定的并发症有关。这篇综述描述了文献和我们中心报道的不同类型的关节镜TFCC手术的并发症类型及其发生率。在关节镜TFCC手术中,并发症发生率和学习曲线随着手术复杂性的增加而增加。相关解剖学,预防和管理并发症,包括神经损伤和刺激,伸肌腱损伤和肌腱炎,骨折,刚度,并讨论了症状或不稳定的持久性。警惕解剖细节和仔细解剖可以帮助减少可能导致令人不安的疼痛和功能丧失的并发症。
    Wrist arthroscopy is a valuable and widely utilized tool in the treatment of triangular fibrocartilage complex (TFCC) injuries. These procedures include synovectomy alone, peri-capsular or transosseous repair, and arthroscopic-assisted reconstruction, and each are associated with specific complications. This review describes the types of complications and their rates in different types of arthroscopic TFCC surgery reported in the literature and in our centre. Across the spectrum of arthroscopic TFCC surgery, complication rates and the learning curve increase with surgical complexity. Relevant anatomy, prevention and management of complications including nerve injury and irritation, extensor tendon injury and tendinitis, fracture, stiffness, and persistence of symptoms or instability are discussed. Vigilance to anatomical details and careful dissection can help to reduce complications that may result in disturbing pain and functional loss.
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  • 文章类型: Journal Article
    带软组织介入关节成形术(STIA)的近端行腕关节切除术(PRC)为解决涉及头状和/或月窝的腕关节关节炎模式提供了一种替代方法。代替腕关节固定术.本系统综述旨在评估晚期腕关节关节炎患者与PRC-STIA相关的临床结果和技术。我们使用包括PubMed,Embase,MEDLINE,和Cochrane中央受控试验登记册。纳入标准涉及报告PRC-STIA患者结局的文章,其中至少有1个相关结局。该分析涵盖了8项研究,涉及106名符合纳入标准的患者(108名手腕)。大多数患者是男性(69%,n=88),平均年龄54.4±12.7岁,平均随访4.8±6.3年。背囊是最常见的介入组织(63%,8项研究中有5项)。接受STIA的患者与仅接受PRC的患者相比,获得了可比的患者报告结果评分。术后疼痛,用视觉模拟量表测量,平均3.7±0.6。手臂的残疾,肩膀,手评分平均为27.8±8分,而患者评估腕部评分平均为41.5±25.9分。在三项研究中报告了五种并发症。对于头状和/或月状窝软骨变性患者,在PRC中添加STIA可产生类似于传统PRC的结果。改善手腕功能,疼痛,和握力以安全和直接的方式。未来的研究应该优先考虑高质量的比较研究,延长随访期,和标准化的核心结果指标,以更全面地了解其在腕关节关节炎治疗中的作用。
    Proximal row carpectomy (PRC) with soft tissue interposition arthroplasty (STIA) presents an alternative approach to addressing wrist arthritis patterns involving the capitate and/or lunate fossa, in lieu of wrist arthrodesis. This systematic review aimed to evaluate clinical outcomes and techniques associated with PRC-STIA in patients with advanced wrist arthritis. We conducted a systematic review using databases including PubMed, Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials. Inclusion criteria involved articles reporting outcomes of patients who underwent PRC-STIA with at least 1 relevant outcome. The analysis encompassed 8 studies involving 106 patients (108 wrists) meeting the inclusion criteria. A majority of patients were men (69%, n = 88), with a mean age of 54.4 ± 12.7 years and an average follow-up of 4.8 ± 6.3 years. Dorsal capsule was the most commonly interposed tissue (63%, 5 out of 8 studies). Patients receiving STIA achieved comparable patient-reported outcome measures scores to those undergoing PRC alone. Postoperative pain, measured by the Visual Analog Scale, averaged 3.7 ± 0.6. The Disabilities of the Arm, Shoulder, and Hand score averaged 27.8 ± 8, while the Patient-Rated Wrist Evaluation score averaged 41.5 ± 25.9. Five complications were reported in three studies. The addition of STIA into PRC for patients with capitate and/or lunate fossa cartilage degeneration yielded outcomes akin to traditional PRC, improving wrist function, pain, and grip strength in a safe and straightforward manner. Future research should prioritize high-quality comparative studies, extended follow-up periods, and standardized core outcome measures for a more comprehensive understanding of its role in wrist arthritis treatment.
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  • 文章类型: Journal Article
    这项研究的目的是确定体重指数(BMI)之间是否存在关系,特别是肥胖,和开放腕管松解术的手术结果。肥胖与腕管综合征的发病率增加有关;然而,尚未研究肥胖对释放后恢复的影响。
    这项研究使用了患者图表的回顾性回顾(n=142)。BMI是根据身高和体重测量值计算的,根据患者的BMI分为以下几类:健康的BMI(18.5-24.9kg/m2),超重(25-29.9kg/m2),肥胖一级(30-34.9公斤/平方米)(OB1),肥胖等级(235-39.9kg/m2)(OB2),或肥胖3级(40+kg/m2)(OB3)。然后通过评估术前疼痛来收集手术结果的数据,术后2周和6周疼痛,术后关节僵硬度,伤口愈合时间,和感染状况。使用卡方分析和多变量逻辑回归分析数据,以评估治疗结果的差异,同时控制可能的混杂变量。
    发现释放时的年龄与BMI呈负相关。健康BMI患者(n=19)在平均年龄59.1岁时接受了释放,而OB3(n=30)在平均年龄46.9岁时接受释放.术后2周和6周,与健康BMI相比,所有三个肥胖组的疼痛改善几率均显着降低。
    我们的结果表明,肥胖可能与需要手术干预的腕管综合征的早期发病率呈正相关。这些数据还表明肥胖患者术后并发症的发生率增加,特别是OB3患者。OB3患者在进行开放释放之前需要了解这些风险。进一步的研究应检查2型糖尿病对腕管释放恢复的影响。
    本研究中包含的信息可用于指导外科医生和患者在进行腕管开放性手术前考虑患者BMI可能带来的效果和结果的潜在改善。
    UNASSIGNED: The purpose of this study was to determine whether a relationship exists between body mass index (BMI), specifically obesity, and surgical outcomes for open carpal tunnel release. Obesity is correlated with increased incidence of carpal tunnel syndrome; however, the effect of obesity on after release recovery has not been examined.
    UNASSIGNED: This study used a retrospective review of patient charts (n = 142). BMI was calculated based on height and weight measurements, and patients were grouped based on their BMI into the following categories: healthy BMI (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), obesity class one (30-34.9 kg/m2) (OB1), obesity class (2 35-39.9 kg/m2) (OB2), or obesity class three (40+ kg/m2) (OB3). Data were then complied on surgical outcomes by assessing preoperative pain, postoperative pain at 2 and 6 weeks, postoperative joint stiffness, wound healing time, and infection status. Data were analyzed using chi-square analyses and multivariable logistic regression to assess the differences in treatment outcomes while controlling for possible confounding variables.
    UNASSIGNED: Age at the time of release was found to be inversely correlated with BMI. Healthy BMI patients (n = 19) underwent release at an average age of 59.1 years, whereas OB3 (n = 30) underwent release at an average age of 46.9 years. The odds of improvement in pain were significantly lower in all three obesity groups when compared with healthy BMI at both 2 and 6 weeks after operation.
    UNASSIGNED: Our results indicate that obesity may be positively correlated with earlier incidence of carpal tunnel syndrome requiring surgical intervention. These data also indicate the increased rates of postoperative complications in obese patients, particularly patients with OB3. Patients with OB3 need to understand these risks before undergoing open release. Further study should examine the impact of type 2 diabetes on carpal tunnel release recovery.
    UNASSIGNED: The information included in this study may be used to guide surgeons and patients when considering the effect and potential improvement in outcomes that may come from addressing patient BMI before open carpal tunnel surgery.
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  • 文章类型: Journal Article
    背景:本研究探讨了开放性腕管松解术中吸烟状况与手术结果之间的关系。吸烟状况以前与骨科手术并发症相关,除非在手术前至少4周戒烟;然而,吸烟对开放式腕管松解术的影响尚未得到具体研究。
    方法:本研究是对过去5年(n=131)患者图表的回顾性分析。在从患者图表中释放腕管时确定吸烟状况。将患者分为吸烟者(n=58)或非吸烟者(n=73)。数据包括术前疼痛,术后2周和6周疼痛,术后腕关节僵硬,伤口愈合时间,和感染状况。数据在卡方上进行比较,费希尔确切,和单边费希尔精确检验。
    结果:吸烟者的感染率明显较高。吸烟者术后麻木和腕部僵硬也明显较高。吸烟者报告术后2周和6周疼痛评分较高。非吸烟者在6周时也更有可能报告疼痛完全消退。
    结论:在本研究中,吸烟与开放性腕管松解术的手术结果并发症相关。这可能归因于免疫系统抑制或伤口愈合不良,这两种都是已知的吸烟副作用。吸烟者术后6周疼痛评分明显高于非吸烟者。接受开放式腕管松解术的吸烟者需要了解手术并发症的风险,并应考虑戒烟以优化手术成功的机会。
    结论:积极吸烟的患者与不吸烟的患者相比,从开放腕管手术中恢复较差。
    BACKGROUND: This study examines the relationship between smoking status and surgical outcomes in open carpal tunnel release. Smoking status has previously been correlated with orthopedic surgical complications unless smoking cessation occurs at least 4 weeks prior to surgery; however, the effect of smoking on open carpal tunnel release has not been specifically examined.
    METHODS: This study is a retrospective review of patient charts over the last 5 years (n = 131). Smoking status was determined at the time of carpal tunnel release from the patients\' charts. Patients were dichotomized as smokers (n = 58) or non-smokers (n = 73). Data comprised preoperative pain, postoperative pain at 2 and 6 weeks, postoperative wrist stiffness, wound healing time, and infection status. Data were compared on chi square, Fisher exact, and one-sided Fisher exact tests.
    RESULTS: Infection rates were significantly higher in smokers. Postoperative numbness and wrist stiffness were also significantly higher in smokers. Smokers reported higher postoperative pain scores at 2 and 6 weeks. Non-smokers were also significantly more likely to report complete pain resolution at 6 weeks.
    CONCLUSIONS: In the present study smoking was associated with surgical outcome complications in open carpal tunnel release. This could be attributed to immune system suppression or to poor wound healing, both of which are known side-effects of smoking. Pain scores 6 weeks post-surgery were significantly higher in smokers than in non-smokers. Smokers undergoing open carpal tunnel release need to understand the risk of surgical complications and should consider smoking cessation to optimize their chances of successful surgery.
    CONCLUSIONS: Patients who were active smokers showed poorer recovery from open carpal tunnel surgery than non-smoking patients.
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  • 文章类型: Journal Article
    为了识别患者,外科医生,与术前计算机断层扫描(CT)扫描对桡骨远端骨折(DRF)的应用相关的损伤特征。此外,我们的目的是确定术前CT是否与孤立的掌侧锁定钢板(VLP)以外的治疗方法相关.
    我们回顾性审查了2016年至2020年在我们的医疗保健系统中所有手术治疗的成人DRF。基线人口统计,损伤,治疗特点,并记录了44名包括在内的外科医生的研究金培训。我们比较了有和没有术前CT的病例,并生成调整后的逻辑回归模型来确定术前CT的几率.
    共纳入由44名外科医生进行的1,204例手术治疗的DRF。在研究期间,CT利用率增加。关节内骨折占病例的76%,1240例中243例(20%),术前进行CT扫描。总的来说,83%的病例使用了孤立的VLP。术前CT的病例更有可能采用其他固定方法(例如背侧钢板)进行治疗。调整后的logistic回归模型显示男性(OR1.62;95%CI:1.16,2.26),关节内骨折(OR3.11;95%CI:1.87,5.81),和相关骨折(OR2.69;95%CI:1.82,3.98)的术前CT发生率显著增加.研究金培训与整体CT利用率的增加无关,但手外科医师更有可能在骨科创伤协会-C3骨折中使用CT。
    患者和损伤特征与手术DRF中的CT使用相关。术前CT与其他固定方法相关,因为有CT的病例更有可能使用除孤立VLP以外的固定方法。CT扫描的成本和收益必须仔细权衡这种方式是否增加价值或改善治疗DRF的结果。
    预后II.
    UNASSIGNED: To identify patient, surgeon, and injury characteristics associated with preoperative computed tomography (CT) scan utilization for operative distal radius fractures (DRF). In addition, we aimed to determine if preoperative CT was associated with treatment methods other than isolated volar-locked plating (VLP).
    UNASSIGNED: We retrospectively reviewed all operatively treated adult DRFs within our health care system from 2016 to 2020. Baseline demographics, injury, treatment characteristics, and the fellowship training of the 44 included surgeons were recorded. We compared cases with and without a preoperative CT, and an adjusted logistic regression model was generated to determine the odds of having a preoperative CT.
    UNASSIGNED: A total of 1,204 operatively treated DRFs performed by 44 surgeons were included. CT utilization increased during the study period. Intra-articular fractures accounted for 76% of cases, and preoperative CT scans were ordered in 243 of 1240 cases (20%). Overall, isolated VLP was used in 83% of cases. Cases with a preoperative CT were more likely to be treated with an alternative method of fixation (such as dorsal plating). The adjusted logistic regression model demonstrated that male sex (OR 1.62; 95% CI: 1.16, 2.26), intra-articular fractures (OR 3.11; 95% CI: 1.87, 5.81), and associated fractures (OR 2.69; 95% CI: 1.82, 3.98) had a significantly increased odds of having a preoperative CT. Fellowship training was not associated with increased CT utilization overall, but hand surgeons were more likely to use a CT in Orthopaedic Trauma Association-C3 fractures.
    UNASSIGNED: Patient and injury characteristics are associated with CT utilization in operative DRFs. Preoperative CTs are associated with alternative fixation approaches, as cases with a CT were more likely to use fixation methods other than isolated VLP. The costs and benefits of CT scans must be carefully weighed against whether this modality adds value or improves outcomes in treating DRFs.
    UNASSIGNED: Prognostic II.
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  • 文章类型: Journal Article
    虽然临床试验提供了指导医疗决策的高质量证据,提前终止试验可能导致时间和资源的损失.我们的目的是调查手和手腕相关疾病的临床试验终止率和原因,并确定与早期试验终止相关的研究特征。
    在ClinicalTrials.gov数据库中查询了所有与手部和腕部相关的临床试验。对所有终止和完成的试验进行审查,记录终止的特征和原因。研究特征包括类型,目的,干预评估,招生,组分配,盲法,试验阶段,赞助商类型,和地理区域。使用卡方检验来确定试验特征与终止状态和完成状态之间的关联。
    总共确定了793项与手和手腕相关的临床试验,77项试验(10%)在完成前终止。最常见的终止原因是“招聘/保留困难,“在37例(48%)终止试验中报告。在比较竞争和终止试验时,主要目的(非观察性研究),登记(<50名患者),和地理区域(北美)都更有可能被终止。终止试验更可能有干预类型调查特定的设备或药物。
    手部和腕部相关疾病的早期试验终止是常见的(10%),患者招募和保留被确定为终止合同的主要原因。涉及潜在商业激励的试验(调查设备或药物的试验)与试验终止率的增加有关。
    在研究设计过程中强调患者招募可能有助于减轻早期临床试验终止的最常见原因。
    UNASSIGNED: While clinical trials provide high-quality evidence guiding medical decision-making, early trial termination can result in both lost time and resources. Our purpose was to investigate the rate of and reasons for clinical trial termination for hand and wrist-related conditions and identify study characteristics associated with early trial termination.
    UNASSIGNED: The ClinicalTrials.gov database was queried for all hand and wrist-related clinical trials. All terminated and completed trials were reviewed, with characteristics and reasons for termination recorded. Study characteristics included type, purpose, intervention assessed, enrollment, group allocation, blinding, trial phase, sponsor type, and geographic region. Chi-square test was used to identify associations between trial characteristics and terminated versus completed status.
    UNASSIGNED: A total of 793 hand and wrist-related clinical trials were identified, with 77 trials (10%) terminated prior to completion. The most common reason for termination was \"recruitment/retention difficulty,\" reported in 37 (48%) terminated trials. In comparing competed versus terminated trials, primary purpose (nonobservational studies), enrollment (<50 patients), and geographic region (North America) were all significantly more likely to be terminated. Terminated trials were more likely to have an intervention type investigating a specific device or drug.
    UNASSIGNED: Early trial termination for hand and wrist-related conditions is common (10%), with patient recruitment and retention identified as the leading cause of termination. Trials involving potential commercial incentives (those investigating a device or drug) were associated with an increased rate of trial termination.
    UNASSIGNED: An emphasis on patient enrollment during study design may aid in mitigating the most common cause of early clinical trial termination.
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